- Simon Ostrovsky - Self
- Fareed Zakaria - Self
- Alison Sweeney - Sami Brady
- Sarah Baker - Allison
- D'Arcy Carden - Homeowner
- Lauren Adams - Homeowner’s friend
- Michael Keaton - Richard Sackler
- Bryan Cranston - Richard Sackler
- Michael Kenneth Williams - Richard Sackler
- Monica Lewinsky - Self
- Stephen Fry - Winston Churchill (voice)
- Glenn Close - Self
- Tracy Morgan - Self
- Bill Nye - Self
- Jane Krakowski - Spokesperson
- Thomas Middleditch - Narrator (voice)
- Devin Trey Campbell - Singer / Dancer
- Hugh Bonneville - Narrator (voice)
- Hugh Bonneville - Self - Guest Star
- Kristen Bell - Sarah Marshall
- Jimmy Kimmel - Self
- Method Man - Self
- David Schwimmer - Self
- Kiefer Sutherland - Jack Bauer
- John Cena - Self
- Alex Trebek - Self
- Paul Rudd - Self
- Catherine O'Hara - Self
- Billy Porter - Self - Guest
- Steve Guttenberg - Self
- Adam Driver - Self
- Ilana Becker - Average American (Toe Lady)
- Seth Baird - Average American
- Greg Hildreth - Average American
- Rock Kohli - Average American (Lotion Guy)
- Rachel Dratch - Wanda Jo
- Rachel Dratch - Wanda Jo Oliver
- Thea McCartan - Average American (Mom)
- Larry Weissman - Average American
- Omar Capra - Security Guard
- Bob Costas - Self (voice)
- Buzz Aldrin - Self
- Richard Branson - Self
- Tim Gunn - Self
- Julia Louis-Dreyfus - Self
- Patrick Stewart - Self
- Alex Webb - DOJ employee
- Alex Webb - CEO / Ladybucks
- Regis Philbin - Self
- Colin Quinn - Voice Over (voice)
- Debi Mae West - Voice Over (voice)
- Ryan Cooper - Mr. Diet Coke
- Sarah Silverman - Self
- Joe List - Edamame
- Suzanne Savoy - Ladybuck
- Ray Singh - Ladybuck
- Kathy Griffin - Self
- Ryan Matthew White - Male Model - Giuseppe
- Aurora Leonard - Pageant Presenter
- Emeka Guindo - Self (voice)
- Seth Meyers - Self
- Seth Meyers - Self - Guest Star
- Robert John Burke - IAB Lieutenant Ed Tucker
- Kathryn Erbe - Detective Alexandra Eames
- John Fiore - Detective Tony Profaci
- Jeff Goldblum - Detective Zach Nichols
- David Carranza - Man with Cell phone
- Chris Henry Coffey - Detective Ted Hickman
- Angela Struck - Miss 1st Contestant
- Angela Struck - Miss First Contestant
- Ricky Garcia - Van suspect
- Uzo Aduba - Self
- Craig Robinson - Self
- Erica Hernandez - Self
- Jane Goodall - Self
- Nate Begle - Puppeteer
- Alberto Bonilla - Flashback Customer
- Alberto Bonilla - Maternity
- Alberto Bonilla - Al (Amazon Employee)
- Alberto Bonilla - Average American
- J.J. Abrams - Self
- Mario Batali - Self
- Michelle Beadle - Self
- Wayne Brady - Self
- Sharon Case - Sharon Collins
- Stephen Colbert - Self
- Richard Kind - Richard Sackler
- Richard Kind - Blobfish (voice)
- Dan Castellaneta - Homer Simpson (voice)
- Anderson Cooper - Self
- Jimmy Fallon - Self
- Jesse Tyler Ferguson - Mitchell Pritchett
- Tom Hanks - Self
- Dwight Howard - Self
- David Letterman - Self
- Joel McHale - Self
- Joshua Morrow - Nicholas Newman
- Ellen Pompeo - Meredith Grey
- Rachael Ray - Self
- Kelly Ripa - Self
- Jon Stewart - Self
- Eric Stonestreet - Cameron Tucker
- Wanda Sykes - Self
- Meredith Vieira - Self
- Mustafa Haidari - Afghan Interpreter
- Faiven Feshazion - Woman
- J.K. Simmons - Voice Over (voice)
- Rob Corddry - Trucker 2
- Rob Corddry - Sheriff Wilkerson
- Brian Huskey - Doctor
- Ashley Blankenship - Model
- Ashley Blankenship - Lotto Girl
- Tara Holt - Pharmaceutical Rep
- Frank Rodriguez - Voice Over (voice)
- Mari Weiss - Voice Over (voice)
- Dale E. Turner - Male Patient
- Adam Newman - Mascot
- Adam Newman - Ronald McDonald
- Adam Newman - Gecko
- Nick Hetherington - Labour Rep
- Polly Lee - British Woman
- Stephanie D'Abruzzo - Mascot
- Stephanie D'Abruzzo - Puppeteer
- Stephanie D'Abruzzo - Curly Bear (voice)
- Danny DeVito - Chemist
- Hope Davis - Duct Inspector
- Vincent D'Onofrio - Dam Inspector
- David Fino - Puppeteer
- David Fino - Mascot
- Michael Gaston - Dam Worker
- Dan Hedaya - Dam Inspector
- Josh Lucas - Bridge Inspector
- Edward Norton - Bridge Inspection Supervisor
- Campbell Scott - Bridge Inspector
- Cassandra Lee Morris - Self (voice)
- Cassandra Lee Morris - Voice Over (voice)
- Marina Franklin - Employee 1
- Zach Cherry - Employee 3
- Ben Hauck - Employee 4
- Cardi B - Self
- Brian Baumgartner - Self
- Jennifer Coolidge - Self
- Will Ferrell - Self
- Frances Mitchell - Scientist
- Frances Mitchell - Average American (Woman 50 shades of grey)
- Leslie Jones - Self
- George Clooney - Self
- Jack McBrayer - Mystery Virus (voice)
- Jack McBrayer - Self
- Jack McBrayer - Dr. Ted Group III
- Tsai Ing-wen - Self - President of Taiwan
- Eliza Ohman - Dancer
- Noel MacNeal - Puppeteer
- Noel MacNeal - Mascot
- Noel MacNeal - Jeff
- Noel MacNeal - Unicorn Puppeteer
- Noel MacNeal - Mr. Nutterbutter
- Noel MacNeal - Puppeteer / Voice Over (voice)
- Noel MacNeal - Totes McGoats
- Noel MacNeal - Funky Monkey
- Noel MacNeal - Polar Bear, Cat Puppeteer
- Noel MacNeal - Dog Paws Puppeteer
- Jalen Rose - Self
- Edward Snowden - Self
- Martin Sheen - Self
- Dave Coleman - Gap Model
- Haley Higgins - H&M Model
- Wyatt Cenac - Bar Patron
- Rachel Feinstein - Bartender
- Alex Karpovsky - Bar Patron
- Henry Leyva - Voice Over (voice)
- Bob Balaban - Self
- America Ferrera - Maternity
- Becky Ann Baker - Deborah
- Becky Ann Baker - Voice Over (voice)
- Erinn Hayes - Maternity
- Connor Ratliff - Man
- Connor Ratliff - Suspect
- Connor Ratliff - Travis
- Connor Ratliff - Sean (Amazon Employee)
- David Wain - Maternity
- Adrienne Warren - Maternity
- Haley Jenkins - Puppeteer
- Haley Jenkins - Dog Paws Puppeteer
- Haley Jenkins - Cat Puppeteer
- Nick Offerman - Self
- Nick Offerman - Voice of Narrator (voice)
- Nick Offerman - The Home Depot Consultant
- Austin Michael Young - Joe Fresh Model
- Austin Michael Young - Model
- Laverne Cox - Self
- Kristen Schaal - Self
- Megan Mullally - Self
- Jonathan Banks - Self
- Kumail Nanjiani - Self
- Aisha Tyler - Self
- Rip Taylor - Self
- Gilbert Gottfried - Jared Kushner (voice)
- Gilbert Gottfried - Self
- William Stephenson - Gerald
- Dean Winters - Brett
- Steve Buscemi - Self - Special Guest
- Steve Buscemi - Chief Dam Inspector
- Luke Gulbranson - Model
- Paul McGinnis - Unicorn
- Paul McGinnis - Cat Puppeteer
- Paul McGinnis - Mascot
- Paul McGinnis - Dog Paws Puppeteer
- Mike Carlsen - Cincinnati Fan
- Mike Carlsen - Bar Patron
- Lorianna Izrailova - Model
- Kaitlyn Raymond - Model
- Mark Ricketson - Model
- Alise Shoemaker - Model
- Danni Wang - Model
- Ali Barthwell - Self
- Matt Vogel - Sesame Street Muppet Performer
- Matt Vogel - Kermit the Frog (voice)
- Helen Mirren - Self (voice)
- Christopher McDonald - Company CEO
- Alex Knight - Trucker 1
- P.L. Brown - Trucker 3
- Pam Murphy - Jeanine
- Tim Meadows - Bruce
- Matt Pavich - Perp
- Matt Pavich - Voice Over (voice)
- Mason Pettit - Voice Over (voice)
- Colin Hanks - Son
- Rob Huebel - Dad
- H. Jon Benjamin - The Blank Void (voice)
- H. Jon Benjamin - Self
- H. Jon Benjamin - Ben
- H. Jon Benjamin - Defendant
- Yun Jeong - Love Interest
- Daniel K. Isaac - Sandwich Artist
- Collin Lim - Development Agent
- Yeena Sung - Young Woman
- Corey Burton - Voice Over (voice)
- Anna Graves - Voice Over (voice)
- Christian Lanz - Voice Over (voice)
- Bobby Cannavale - Self
- RuPaul - Self
- Brian Cox - God
- Caroline Bednar - American Cheeseburger Family Daughter
- Michael Bolton - Self
- Phillip Chorba - American Cheeseburger Family Dad
- Michael Torpey - Manager
- Michael Torpey - Lenny
- Michael Torpey - Self
- Michael Torpey - Voice of the Company 1
- Michael Torpey - Steve
- Lara MacLean - Sesame Street Muppet Performer
- Lara MacLean - Mascot
- Mylinda Hull - American Cheeseburger Family Mother
- Matthew Mindler - American Cheeseburger Family Son
- Mike Myers - Self
- Kenny G - Self
- Kathryn Hahn - Wife
- Salli Saffioti - Voice Over (voice)
- Jason Jones - Voice Over (voice)
- Chris Parnell - HOA Ambassador
- Chris Parnell - Voice Over (voice)
- Seth Rogen - Husband
- Mike Birbiglia - Self
- Jerrod Carmichael - Self
- Dante Hoagland - Self
- Rob Riggle - Voice Over (voice)
- Rob Riggle - Self
- Martin Starr - Self
- Kat Cressida - Voice Over (voice)
- Andy Daly - Chipotle Guy
- Peter Jackson - Self
- Courter Simmons - Flying Dildo
- Kapil Bawa - Scientist
- Tim Washer - Scientist
- Sylvia Ward - Alison Grimes
- Chazz Menendez - Grimes Ad Character
- Dean Neistat - Grimes Ad Character
- Roy Samuelson - Voice Over (voice)
- Mike Shapiro - Voice Over (voice)
- Stephen Hawking - Self - Guest
- André Sogliuzzo - Voice Over (voice)
- George R. R. Martin - Self - Special Guest
- Summer Moore - Housewife
- Jennifer Stewart - Lady Liberty
- Richard Toth - George Washington
- Paul Radki - Puppeteer
- Bonale Fambrini - Singapore Gambling Cast
- Jennifer Barnhart - Puppeteer
- Jennifer Barnhart - Reddy Kilowatt (voice)
- Carol Herman - Kind Old Woman
- Nicole Sullivan - Pam
- Cedric Yarbrough - Ron
- Brian McCarthy - Voice of Farmer (voice)
- Sean Modica - Voice Over (voice)
- Jake Lacy - Self
- Rich Sommer - Self
- Michelle Trachtenberg - Voice Over (voice)
- Adam Pally - Self
- Adam Pally - Boeing Employee
- Yo-Yo Ma - Voice Over (voice)
- Ryan Dillon - Sesame Street Muppet Performer
- Eric Jacobson - Sesame Street Muppet Performer
- Carmen Osbahr - Sesame Street Muppet Performer
- Tucker Carlson - Self (archive footage)
- Joe Biden - Self (archive footage)
- Marjorie Taylor Greene - Self (archive footage)
- Lin-Manuel Miranda - Self
- Alex Lacamoire - Pianist
- Alexandria Ocasio-Cortez - Self (archive footage)
- Rick Scott - Self (archive footage)
- Peter Grosz - Self
- Sunita Mani - Self
- BD Wong - Self
- Susan Collins - Self (archive footage)
- Wendi McLendon-Covey - Self
- Don Young - Self (archive footage)
- Peter Welch - Self (archive footage)
- Jen Psaki - Self (archive footage)
- Tim Bagley - Todd
- Tim Bagley - Lawyer
- Eugene Mirman - Butternut Squash (voice)
- Eugene Mirman - Self
- Ellen Marlow - Amber
- Carolyn Maloney - Self (archive footage)
- Milo Ventimiglia - Jack Pearson
- Kristin Chenoweth - Self
- Billy Eichner - Self
- Brian Tweedy - Talent Double
- Matt Berry - Train Narrator (voice)
- Marla Mindelle - Voice of the Company 2
- Matt Barats - Consultant 1
- Ronny Chieng - Consultant 2
- Desi Domo - Consultant 3
- Freddie Kuguru - Assistant
- Vin Knight - Executive
- Molly Brown - Voice Over (voice)
- Brian Cade - Voice Over (voice)
- Rose Byrne - Boeing Executive
- David Costabile - Boeing Employee
- Roy Wood Jr. - Boeing Employee
- Marc Petrosino - Puppeteer
- Amber Ruffin - Mom
- Jabari Striblin - Child
- Mark McKinney - Peach (voice)
- Fred Armisen - Sweet Potato (voice) / Tomatillo (voice)
- Nick Kroll - Cantaloupe (voice) / Coconut (voice)
- Cecily Strong - Ginger (voice) / Orange (voice)
- June Yoon - Voice-Over
- Yamaneika Saunders - Brenda
- Usher - Self
- Josh Groban - Self
- Sheryl Crow - Self
- John Mellencamp - Self
- Dan Reynolds - Self
- Ann Wilson - Self
- Nancy Wilson - Self
- Cyndi Lauper - Self
- 'Weird Al' Yankovic - Self
- Keegan-Michael Key - Responsible Guy
- Wilmer Valderrama - Advice-Giving Bird
- Fred Willard - Self
- William Shatner - Self
- Lily Tomlin - Self
- Cloris Leachman - Self
- Neil deGrasse Tyson - Self
- Rita Moreno - Self
- Russell Crowe - Self
- Armie Hammer - Self
- John Oliver
- David Kaye
Glenn Close interpreta a Self en la serie.
Danny DeVito interpreta a Chemist en la serie.
Jonathan Banks hace el papel de Self.
Tom Hanks hace el papel de Self.
Edward Norton interpreta a Bridge Inspection Supervisor en la serie.
Kathy Griffin interpreta a Self en la serie.
Kiefer Sutherland interpreta a Jack Bauer en la serie.
John Oliver interpreta a Self - Host en la serie.
Patrick Stewart interpreta a Self en la serie.
Christopher McDonald interpreta a Company CEO en la serie.
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