- Paul Blackthorne - Tony Kadjic
- Rick Overton - FBI Agent Taggert
- Cedric Young - Nigerian Businessman
- Peter Riegert - Peter Blanchard
- Griffin Dunne - Marcus Starke
- Wade Williams - Nickolas Kusen
- Alona Tal - Kaye Lynn Gold
- Armin Shimerman - Dr. Patemkin
- Beth Broderick - Monica Hunter
- Pasha D. Lychnikoff - Head Goon
- Marisa Guterman - Marcy
- Matt Lindland - Tank Conklin
- Charles Martin Smith - Glenn Leary
- Sara Rue - Marissa Devins
- Lauren Holly - Ms. Tobey Earnshaw
- Luke Perry - Dalton Rand
- Ayanna Berkshire - Sarah Pennington
- Richard Kind - Mayor Bradford Culpepper III
- Matt Keeslar - Alexander Lundy
- Apollo Robbins - Apollo
- Brent Spiner - William Quint
- Kitty Swink - Judge Kerry Durham (uncredited)
- John Storey - Paul Richards
- Mia Riverton - Allie Stanbrook
- Elisabetta Canalis - The Italian
- Scott Michael Morgan - Don Paolo Brancato
- Jaime Langton - Justine Yang
- Sean O'Bryan - Kip Bryden
- Lea Zawada - Molly Connell
- Erik Jensen - John Connell
- Lisa Brenner - Dr. Anne Hannity
- Diego Velazquez - Young Nathan Ford
- Johanna Braddy - Hayley Beck
- Natalie Shershow - A'Yan
- Brian Goodman - Jed Rucker
- Melik Malkasian - Eddie Maranjian
- Victor Morris - Deputy US Marshal Robert Corville
- Kevin E. West - Erik Casten
- Jack Armstrong - William Taylor Price
- Jennifer Skyler - Dr. Leigh Jameson
- Noa Tishby - Mikel Dayan
- Salvator Xuereb - Jim Kerrity III
- Anna Campbell - Ruth Walton
- Tom Choi - Russell Pan
- Alan Smyth - Mark Doyle
- David Ellison - Ballard
- Odessa Rae - Cora McRory
- Katie O’Grady - Special Agent Amy Nevins
- Clayne Crawford - Mr. Quinn
- Alex Carter - Sterling's Henchman
- Garrett M. Brown - Dr. Frank
- Sam Anderson - Henry Retzing
- Jonathan Chase - Randy Retzing
- Danny Strong - Dennis Retzing
- Michael Kagan - Allen Haldeman
- Dan Lauria - Nicky Moscone
- Nicole Sullivan - Heather Moscone
- David S. Lee - Nicolas Petrovic
- Kathleen Gati - Irina Larenko
- Stacey Moseley - Dana Morton
- Michael O'Neill - Judge Roy
- Michael McGrady - Sheriff Hastings
- D.B. Sweeney - Father Paul
- Scott Lowell - Andrew Grant
- Rick Hoffman - Alan Foss
- Jaime Ray Newman - Aimee Martin
- Tony Bill - Pierson
- Dennis Bateman - Adam Worth IV
- Arye Gross - Larry Duberman
- Kari Wuhrer - Miranda Miles (Nikki)
- Glen Baggerly - Vorhees
- Giancarlo Esposito - Alexander Moto
- Michael O'Keefe - Darren Hoffman
- Katie Lowes - Ashley Moore
- John Schneider - Mitchell Kirkwood
- Garland Lyons - Owens
- Melise - Josie
- David Meunier - Pieter
- Bruce Davison - Dan Blackwell
- Annie Fitzgerald - Debra Pierce
- John Billingsley - Coswell
- James Frain - John Douglas Keller
- Spencer Garrett - Mark Vector
- Dave Foley - Eben Dooley Jr.
- Wil Wheaton - Colin Mason
- Jeri Ryan - Tara Cole
- Jeri Ryan - Tara Carlisle
- Charlie Brewer - Bad Santa
- Alastair Duncan - President Edwin Ribera
- Goran Visnjic - Damien Moreau
- Cameron Daddo - John Drexel
- Haley Talbot - Karen Scott
- William Russ - Morris Beck
- Michael Gladis - Reed Rockwell
- Danny Glover - Charlie Lawson
- Brett Rice - Alfred Ross
- Mitch Pileggi - Colin Saunders
- Anne-Marie Johnson - Darlene Wickett
- David Rees Snell - Greg Sherman
- Gerald Downey - FBI Agent McSweeten
- Tina Holmes - Linda
- Danny Bruno - Agent Bob
- James Tolkan - Dean Chesny
- Tom Amandes - Livingston
- Ayla Kell - Olivia Livingston
- Mark Sheppard - Jim Sterling
- Jonathan Keltz - Travis Zilgram
- Josh Randall - Fred Bartley
- Blake Lindsley - Felicia Van Buren
- Peter Stormare - Gunter Hanzig
- Wil Traval - Craig Mattingly
- Robert Blanche - Detective Captain Bonanno
- Drew Powell - Jack Hurley
- Lisa Schurga - Peggy
- Emma Caulfield Ford - Meredith
- Val Landrum - Detective Grayson
- Cas Anvar - Oscar San Guillermo
- Marissa Neitling - Christina Valada / Lacey Beaumont
- David Ogden Stiers - Walt Whitman Wellesley IV
- Todd Stashwick - Tommy Madsen
- Sasha Barrese - Barbara Madsen
- Tom Skerritt - Jimmy Ford
- Richard Chamberlain - Archie Leach
- Leon Rippy - Jack Latimer
- Laura Duyn - Arbiter
- John Rogers - Director
- Inger Tudor - Dr. Laroque
- Jonathan Kowalsky - PFC Dwight Caplan
- Ben O'Rourke - Guard #1
- Tisha Terrasini Banker - News Reporter
- Robert Pine - Congressman Jenkins
- Richard Cox - Charles Dufort
- Jake McLaughlin - Cpl. Robert Perry
- Lee Reherman - Grady
- Adam Baldwin - Colonel Michael Vance
- Matthew Lillard - Gabe Erickson
- Demetrius Sager - Dandy
- Lisa Foiles - Trina
- Sofia Pernas - Sister Lupe
- David Castellani - Joe Morton
- Treat Williams - Pete Rising
- John Rogers
- Doug Young
- Dean Devlin
Rick Overton interpreta a FBI Agent Taggert en la serie.
Adam Baldwin interpreta a Colonel Michael Vance en la serie.
Tom Skerritt interpreta a Jimmy Ford en la serie.
James Tolkan interpreta a Dean Chesny en la serie.
Peter Stormare hace el papel de Gunter Hanzig.
William Russ interpreta a Morris Beck en la serie.
Griffin Dunne hace el papel de Marcus Starke.
Treat Williams interpreta a Pete Rising en la serie.
Giancarlo Esposito hace el papel de Alexander Moto.
Wil Wheaton interpreta a Colin Mason en la serie.
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