- Beth Grant - Carlotta Mayfair
- Erica Gimpel - Elena Fielding
- Annabeth Gish - Deirdre Mayfair
- Tobias Jelinek - Daniel Lemle
- Cameron Inman - Young Deirdre
- Geraldine Singer - Millie Mayfair
- Deneen Tyler - Delphine
- Billy Slaughter - Dr. Vernon Lamb
- Jordan Cox - Max
- Melissa Chambers - Mawbel
- Jim Gleason - Dr. Norman Keck
- Danielle Lyn - Dr. Maya Kang
- Joseph Meissner - Father Duffy
- Carson Minniear - Joey
- Annie Gaia - Surgical Assistant
- Monica Monica - Sister Elise
- Kamille McCuin - Mayfair Clan 2
- Eric Esteban - Priest
- Kyler Porche - Nate
- Martin Covert - Butler
- Chris Greening - Young Man 1
- Boyana Balta - Cake Woman
- Hannah Alline - Suzanne Mayfair
- Ravi Naidu - Samir
- Nadine Lewington - Aoife
- Sylvia Grace Crim - Dr. Noreen Davis
- Emma Rose Smith - Florie
- Shannon Nicole - Paramedic
- Choppy Guillotte - Hotel Clerk
- Victoria Patenaude - Ghost Tour Guide
- Hick Cheramie - Aoife's Poor Soul
- Jen Richards - Josephine 'Jojo' Mayfair
- Keyara Milliner - Odette Grieve
- Ian Hoch - Keith Murfis
- Ryan Glorioso - Magic Mark
- Jason Kirkpatrick - Scottish Man
- Vivian Fleming-Alvarez - Police Officer
- Elliot Hamilton - Bell Boy
- Aaron Jay Rome - Hotel Manager
- Dayna Beilenson - Old Woman 2nd Line
- Jean-Pierre Vertus - Janitor
- Andy Dylan - Suspect
- Bowie Hamilton - Scottish Man #3
- Dari Lynn Griffin - Young Scottish Woman
- Richard Haylor - Sam the Butler
- Robert Aberdeen - Scottish Priest
- Richard Pait - Father Ransome
- Jo-Ann Robinson - Flower Guild Woman 1
- Dennis Boutsikaris - Albrecht
- Madison Wolfe - Tessa Mayfair
- Charlayne Woodard - Dolly Jean Mayfair
- Leslie Castay - Alicia Mayfair
- Suleka Mathew - Arjuna
- Joshua Mikel - Matthew Hopkins
- Kellan Rhude - Stuart Townsend
- Jessie Terrebonne - Scotland Woman
- Mason James Bienvenue - Scotland Child 1
- Chris Coy - Arlo Whittle
- Terese Aiello - Delia Mayfair
- Sophie Marie White - Beth Mayfair
- Mary Claire Smythe - Shelby Mayfair
- Samantha Beaulieu - Lilia Mayfair
- Josh Whites - Rodney
- Matthew Rimmer - Village Man
- Eduardo Losan - Alonso
- Olive Elise Abercrombie - Daphne Mayfair
- Laura Flannery - Angelique Mayfair
- Sam Evans - Patrick
- J. Omar Castro - Burly Talamasca Agent
- Carly Roland - Deborah
- Casey Groves - Julien Mayfair
- Chelsea Edmundson - Antha Mayfair
- Michael Uppendahl
- Axelle Carolyn
- Haifaa al-Mansour
- Alexis Ostrander
- Anne Rice
- Mary Angélica Molina
- Jeff Freilich
- Esta Spalding
- Dylan Jury
- Mark Johnson
- Steph Accetta
- Annie Josephine Rhodes
- Will Bates
Alexandra Daddario interpreta a Dr. Rowan Fielding en la serie.
Tongayi Chirisa interpreta a Ciprien 'Sip' Grieve en la serie.
Jack Huston hace el papel de Lasher.
Harry Hamlin interpreta a Cortland Mayfair en la serie.
Capítulo disponible en las siguientes plataformas:
