- Roger Hammond - Jabez Wilson
- Tim McInnerny - John Clay
- Natasha Richardson - Violet Hunter
- George Costigan - Wilson Kemp
- Richard Wilson - Duncan Ross
- Frank Middlemass - Henry Baker
- Ronald Pickup - Barrymore
- William Ilkley - Selden
- Cheryl Campbell - Lady Frances Carfax
- Julian Curry - Albert Shlessinger
- Mary Cunningham - Miss Calder
- Jack Klaff - The Hon. Philip Green
- Nicholas Fry - Hotel Manager
- Michael Jayston - The Earl of Rufton
- Anthony Benson - Vicar
- Anthony Schaeffer - Bank Official
- Daniel Massey - J. Neil Gibson
- Margo Stanley - Woman in Undertakers
- Celia Gregory - Maria Gibson
- Catherine Russell - Grace Dunbar
- Niven Boyd - Marlow Bates
- Andrew Wilde - Sergeant Coventry
- Philip Bretherton - Mr. Joyce Cummings Q.C.
- Robin Ellis - Sir Robert Norberton
- Elizabeth Weaver - Lady Beatrice Falder
- Frank Grimes - John Mason
- Denise Black - Carrie Evans
- Michael Bilton - Stephens
- Martin Stone - Sandy Bain
- James Coyle - Samuel Brewer
- Peter Vaughan - John Turner
- Jude Law - Joe Barnes
- Jonathan Barlow - Inspector Summerby
- Alan Pattison - Harvey
- Leslie Schofield - William McCarthy
- James Purefoy - James McCarthy
- Cliff Howells - Crowder the Gamekeeper
- Anthony Valentine - Baron Gruner
- David Langton - Sir James Damery
- Abigail Cruttenden - Miss Violet Merville
- John Pickles - Jarvis
- Kim Thomson - Kitty Winter
- Charles Kay - Professor Presbury
- Roy Holder - Shinwell Johnson
- Andy Bradford - First Thug
- Adrian Lukis - Jack Bennett
- Sarah Woodward - Edith Presbury
- Anna Mazzotti - Alice Morphy
- James Tomlinson - Macphail
- Peter Guinness - Wilcox
- Steve Swinscoe - Jenkins
- Anthony Havering - Secretary of the Zoological Society
- Eric Sykes - Horace Harker
- Gerald Campion - Morse Hudson
- Vincenzo Nicoli - Pietro
- Steve Plytas - Venucci Snr.
- Vernon Dobtcheff - Mendelstam
- Marina Sirtis - Lucrezia
- Emil Wolk - Beppo
- Nadio Fortune - Beppo's Cousin
- Michael Logan - Josiah Brown
- Alan Howard - The Duke of Holdernesse
- Christopher Benjamin - Dr. Huxtable
- Nicholas Gecks - James Wilder
- Michael Bertenshaw - Aveling
- Brenda Elder - Mrs Hayes
- Robin Hunter - Major Sholto
- William Abney - Rivers
- Alf Joint - McMurdo
- John Thaw - Jonathan Small
- Patrick Allen - Colonel Sebastian Moran
- Kiran Shah - Tonga
- James Bree - Coroner
- Jenny Seagrove - Miss Mary Morstan
- Richard Bebb - Sir John Hardy
- Derek Deadman - Williams
- Robert Addie - Mr. Murray
- Ronald Lacey - Thaddeus & Bartholomew Sholto
- Ishaq Bux - Lal Chowder
- Paul Lacoux - The Hon. Ronald Adair
- Will Tacey - Coroner
- Will Tacey - Clergyman
- Terence Skelton - Captain Morstan
- Marjorie Sudell - Mrs. Bernstone
- Emrys James - Inspector Athelney Jones
- Roger Rowland - Butler
- Gordon Gostelow - Sherman
- Lila Kaye - Mrs. Mordecai Smith
- William Ash - Jack Smith
- Tenniel Evans - Hilton Cubitt
- Conrad Phillips - Sir Eustace Brackenstall
- Betsy Brantley - Elsie Cubitt
- Courtney Roper-Knight - Wiggins
- Anne-Louise Lambert - Lady Mary Brackenstall
- Zulema Dene - Theresa Wright
- Tommy Wright - Boatyard Workman
- Dave Atkins - Mordecai Smith
- Eugene Lipinski - Abe Slaney
- Oliver Tobias - Captain Croker
- Badi Uzzaman - Kartar Singh
- Lorraine Peters - Mrs. King
- Nicolas Chagrin - Mr. Viviani
- Renu Setna - Achmet
- Ravinder Singh Reyett - Jagodish Singh
- Denis Quilley - Dr Leon Sterndale
- Paul Jaynes - Walker
- Damien Thomas - Mortimer Tregennis
- Gayle Hunnicutt - Irene Adler
- Bernard Atha - Dr Carthew
- Wolf Kahler - King of Bohemia
- David Ross - Inspector Martin
- Michael Aitkens - Reverend Roundhay
- Michael Carter - Godfrey Norton
- David Gwillim - Percy Phelps
- Freda Dowie - Mrs. Porter
- Max Faulkner - John
- Gareth Thomas - Joseph Harrison
- Norman Bowler - Owen Tregennis
- Tim Pearce - Cabby
- Alison Skilbeck - Annie Harrison
- Peter Shaw - George Tregennis
- Ronald Russell - Lord Holdhurst
- Tessa Worsley - Mrs. Willard
- John Saunders - Dr Richards
- Tom Watt - 1st Loafer
- Pamela Pitchford - Mrs. Tangey
- Frank Moorey - Police Inspector
- Peter Barkworth - Colonel Ross
- David Baukham - 1st Big Man (as David Bauckham)
- Barry Lowe - John Straker
- David Rodigan - Inspector Forbes
- Edward York - 2nd Big Man
- Eve Matheson - Miss Tangey
- Jonathan Coy - Fitzroy Simpson
- John Malcolm - Tangey
- Malcolm Storry - Inspector Gregory
- John Taylor - Dr. Ferrier
- John Graham Davies - 1st Young Man (as John Graham Davies)
- John Carr - 1st Burglar
- Barbara Wilshere - Violet Smith
- John Castle - Carruthers
- Sally Faulkner - Mrs. Straker
- Michael Siberry - Woodley
- Russell Hunter - Silas Brown
- Ellis Dale - Williamson
- Nicholas Teare - Dawson
- Norman Jones - Henry Wood
- Geoffrey Banks - Race Official
- Lisa Daniely - Nancy Barclay
- Derek Pykett - Gipsy (uncredited)
- Stafford Gordon - Landlord
- Denys Hawthorne - James Barclay
- Fiona Shaw - Miss Morrison
- Paul Chapman - Major Murphy
- Shelagh Stephenson - Jane
- Michael Lumsden - Young Henry Wood
- Catherine Rabett - Young Nancy
- James Wilby - Young Barclay
- Maggie Holland - Mrs Fenning
- Colin Campbell - Private Bates
- David John - Ned Hunter
- Joanna Roth - Alice Turner
- Jack Carr - Reuben Hayes
- Alastair Duncan - Dr. Mortimer
- Peter Elliott - Great Ape
- Joss Ackland - Jephro Rucastle
- Lottie Ward - Mrs Rucastle
- Patience Collier - Miss Stoper
- Angela Browne - Mrs Toller
- Peter Jonfield - Toller
- Alkis Kritikos - Mr Melas
- Anton Alexander - Paul Kratides
- Victoria Harwood - Sophy Kratides
- Oliver Maguire - Inspector Gregson
- Rita Howard - Mrs Stern
- Peter Mackriel - Ticket Inspector
- Rosalie Crutchley - Mrs Lexington
- Jonathan Adams - Jonas Oldacre
- Andy Rashleigh - Constable
- Anthony Langdon - Tramp
- Helen Ryan - Mrs McFarlane
- Helen Ryan - Princess of Wales
- Ted Carroll - Seafaring Tramp
- Nicholas Clay - Dr Percy Trevelyan
- Patrick Newell - Blessington
- Tim Barlow - Russian Count
- Brett Forrest - Count's Son
- Charles Cork - Cartwright
- John Ringham - Inspector Lanner
- David Squire - Fenton
- Norman Mills - Detective
- Rosalind Knight - Countess of Morcar
- Ken Campbell - James Ryder
- Desmond McNamara - John Horner
- Amelda Brown - Jennie Horner
- Brian Miller - Inspector Bradstreet
- Frank Mills - Peterson
- Don McCorkindale - Windigate
- Eric Allan - Breckendridge
- Maggie Jones - Mrs Oakshott
- John Cannon - Rough
- Eric Kent - Rough
- Ted Beyer - Warder
- Bruce Dukov - Sarasate
- John Woodnutt - Mr. Merryweather
- Reginald Stewart - Doorman
- Ian Bleasdale - Accountant
- Malcolm Weaver - Archie
- Paul Williamson - Inspector Hopkins
- Rosalyn Landor - Helen Stoner
- Jeremy Kemp - Dr Grimesby Roylott
- Tim Condren - Thorne
- Stephen Mallatratt - Percy Armitage
- Michael Loney - Fowler
- Olivier Pierre - Director of the Louvre
- Claude Le Saché - Minister of the Interior
- Michael Goldie - The Artist
- Robert Henderson - American Millionaire
- Jim Dunk - Porter at Victoria
- Paul Humpoletz - Herr Steiler
- Simon Adams - Swiss Youth
- Patricia Hodge - Lady Hilda Trelawney Hope
- Harry Andrews - Lord Bellinger
- Stuart Wilson - Rt. Honourable Trelawney Hope
- Sean Scanlan - Constable MacPherson
- Yves Beneyton - Eduardo Lucas
- Johanna Kirby - Rachel Howells
- Alan Bennion - Bates
- Teresa Banham - Janet Tregallis
- Michael Culver - Sir Reginald Musgrave
- James Hazeldine - Richard Brunton
- Ian Marter - Inspector Fereday
- Patrick Blackwell - Tregallis
- Eleanor David - Mrs St Clair
- Patricia Garwood - Mrs Whitney
- Clive Francis - Neville St Clair
- Terence Longdon - Isa Whitney
- Albert Moses - Lascar
- Kika Markham - Miss Burnet
- Donald Churchill - Scott Eccles
- Basil Hoskins - Henderson
- Trader Faulkner - Lucas
- Arturo Venegas - Garcia
- Guido Adorni - Luis
- Sonny Caldinez - The Mulatto
- Jonathan Newth - Colonel Valentine Walter
- Geoffrey Bayldon - Sidney Johnson
- Sebastian Stride - Cadogan West
- Robert Fyfe - Clerk at Woolwich Station
- John Rapley - Underground Official
- Simon Carter - Butler
- Derek Ware - Hugo Oberstein
- Stephen Crane - 1st Platelayer
- Raymond Adamson - Sir Charles Baskerville
- Rosemary McHale - Mrs. Barrymore
- Kristoffer Tabori - Sir Henry Baskerville
- Edward Romfourt - Purser
- James Faulkner - Stapleton
- Philipp Dettmer - Pageboy
- Fiona Gillies - Beryl Stapleton
- Bernard Horsfall - Frankland
- Michael Wynne - Josiah Barnes
- Michael Wynne - Commissionaire Jenkins
- Don McKillop - Vicar of Grimpen
- Myrtle Devenish - Postmistress
- Elizabeth Spender - Laura Lyons
- Donald Bisset - Manservant (uncredited)
- Freddie Jones - Inspector Baynes
- Freddie Jones - Pedlar
- Nickolas Grace - Bertrand
- Robert Hardy - Charles Augustus Milverton
- David Scase - Art Gallery Owner
- John Labanowski - Inspector Morton
- John Labanowski - Inspector Athelney Jones
- John Gill - Mr Sutro
- John Gill - Driver
- Howard Gaye - Lewis, Dorking's Batman
- Stephen Simms - Stokes
- Serena Gordon - Lady Eva Blackwell
- Alan Rothwell - Tronson, The Butler
- Gwen Ffrangcon Davies - The Dowager
- Sarah McVicar - The Hon. Charlotte Miles
- Hans Meyer - Hebworth (Alias Veitch)
- Stephen Tomlin - Perkins
- Stephen Tomlin - PC Ware
- David Mallinson - Colonel Dorking
- Sophie Thompson - Agatha
- Brian Mitchell - Harry, Earl of Dovercourt
- Belinda Peters - Lillie
- Jimmy Hibbert - Hobbs, The Painter
- Norma West - Lady Diana Swinstead
- Juliet Aubrey - Dolores
- Roy Marsden - John Stockton
- Keith Barron - Rob Ferguson
- Yolanda Vazquez - Carlotta
- Maurice Denham - Reverend Merridew
- Richard Dempsey - Jack
- Jason Hetherington - Michael
- Elizabeth Spriggs - Mrs Mason
- Peter Geddis - Mr Gresty
- Kate Lansbury - Mrs Gresty
- Maria Redmond - Vera Gresty
- Hilary Mason - Miss Ruddock
- Eileen O'Brien - Mrs Carter
- Andy Abrahams - Mr. Carter
- Marcello Walton - Tom Carter
- Paul Parris - Albert, The Pageboy
- Simon Williams - Lord Robert St. Simon
- Anthony Price - Ricardo, The Baby
- Paris Jefferson - Henrietta Doran
- Anna Calder-Marshall - Lady Helena / Agnes Northcote
- Geoffrey Beevers - Inspector Montgomery
- Phillada Sewell - Lady Mary
- Elspeth March - Lady Blanche
- Heather Chasen - Hon. Amelia St. Simon
- Bob Sessions - Aloysius Doran
- Joanna McCallum - Flora Miller
- Myles Hoyle - Thomas Floutier
- Bruce Myers - Gallagher
- Robin Hart - Oswald
- Peter Graves - George Tidy
- Mary Ellis - Lady Florence
- Mary Ellis - Mary Maberley
- Peter Warnock - Moulton
- Joyce Grundy - Esther
- Tres Hanley - Alice
- Claudine Auger - Isadora Klein
- Caroline Blakiston - Dowager Duchess
- Gary Cady - Douglas Maberley
- Ben Pullen - Duke of Lomond
- Barbara Young - Susan
- Peter Wyngarde - Langdale Pike
- Michael Graham - Haines-Johnson
- Steve Toussaint - Steve Dixie
- Susannah Harker - Adelaide Savage
- Caroline John - Mrs Carnac
- Rachel Rice - Marina Savage
- Shaughan Seymour - Penrose Fisher
- Jonathan Hyde - Culverton Smith
- Hugh Bonneville - Victor Savage
- Roy Hudd - John Gedgrave (aka Frank Carter)
- T.R. Bowen - Charles Damant
- Rowland Davies - Colonel Carnac
- Malcolm Hebden - Staples
- Colin Stevens - Police Sergeant
- Anna Carteret - Anna
- Natalie Morse - Susan Tarlton
- Patricia Kerrigan - Abigail Crosby
- Kathleen Byron - Mrs Marker
- Frank Finlay - Professor Coram / Sergius
- Nigel Planer - Inspector Hopkins
- Christopher Guard - Willoughby Smith
- Roger Ringrose - Alexis
- Betty Marsden - Mrs Warren
- Kenneth Connor - Mr Warren
- John Hallam - Gorgiano
- James Coombes - Gennaro Lucca
- Kerry Shale - Leverton
- Joseph Long - Firmani
- Charles Gray - Mycroft Holmes
- Phyllis Calvert - Agnes Garrideb
- Barbara Hicks - Emily Garrideb
- Jon Finch - Count Sylvius
- James Villiers - Lord Cantlemere
- Denis Lill - Inspector Bradstreet
- Gavan O'Herlihy - John Garrideb / James Winter
- Richard Caldicot - Nathan Garrideb
- Harry Landis - Ikey Sanders
- Ciarán Hinds - Jim Browner
- Tom Chadbon - Inspector Hawkins
- Joanna David - Susan Cushing
- Deborah Findlay - Sarah Cushing
- Ann Rye - Mrs Clyde
- Thierry Harcourt - Marcel Jacottet
- Richard Dixon - Mr Bradbrook
- Renny Krupinski - Murdoch Gull
- Andrew Readman - Postman
- Andy Tomlinson - Policeman
- Stephen Howard - Mr. Ferguson
- Rachel Smith - Lucy
- Arthur Conan Doyle
- Michael Cox
Alan Howard interpreta a The Duke of Holdernesse en la serie.
Marina Sirtis interpreta a Lucrezia en la serie.
Peter Shaw hace el papel de George Tregennis.
Peter Vaughan interpreta a John Turner en la serie.
Vernon Dobtcheff interpreta a Mendelstam en la serie.
Ronald Lacey interpreta a Thaddeus & Bartholomew Sholto en la serie.
Wolf Kahler interpreta a King of Bohemia en la serie.
Clive Francis interpreta a Neville St Clair en la serie.
Rosalind Knight hace el papel de Countess of Morcar.
Jeremy Brett interpreta a Sherlock Holmes en la serie.
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