- Kathleen McClellan - Terry
- Jennifer Coolidge - Helen
- Katie Volding - Wendy Stiles
- Mariam Parris - Bonnie Stiles
- Lisa Darr - Dr. Mandell
- Gus Buktenica - Doctor
- Jasmine Guy - Allegra
- Flora Burke - Mrs. Mendelson
- Casey Sander - Ron Dale
- Jade Carter - Joey
- Jerry Lambert - Rick
- George Hamilton - Don Rio Sepulveda
- Brandon de Paul - Timmy Little
- Mo Gaffney - Mayvis Little
- Joe Gieb - Little Guy
- Fred Willard - Larry Little
- Patrick Cranshaw - Uncle Earl
- Ann Cusack - Delilah
- Joel Hurt Jones - Howard
- Camille Winbush - Girl Scout #2
- Brenan T. Baird - Pilot
- Alfred Dennis - Hasidic Jew
- Big Nate Kanae - Hawaiian Guy #1
- Ari Karczag - Lars
- Raymond Ma - Mr. Li
- Louis Mustillo - Jerry
- Glenn Shadix - Mr. Rook
- Roger Velasco - Paolo
- Chad Carr - Teddy
- Marina Malota - Judge Cher
- Andre Jamal Kinney - Carl
- Myra Turley - Mrs. Cahill
- Michael Welch - Kyle
- Lane Davies - Stan
- Sharon Mahoney - Sarah
- Matt McCoy - Ben
- Brian Klugman - Noodle
- Scot Zeller - Stu
- Rue McClanahan - Aunt Lou
- Loren Freeman - Terry
- Kelly Mantle - Drew
- Luigi Amodeo - Giancarlo
- Soren Fulton - Boy
- Burke Moses - Jay Roark
- Michael James Reed - Father
- Lise Simms - Shirl
- Mark Tymchyshyn - Harve
- Kavan Reece - Teenage Boy
- Natasha Slayton - Jesse
- Estelle Getty - Sophia Gates
- Sean Smith - Waiter
- John Valdetero - Customer
- Elizabeth Beckwith - Sabrina
- Christian Clemenson - Dog Consultant
- Alex Trebek - Alex Trebek (voice)
- Robert Covarrubias - Jacinto
- Rusty Schwimmer - Mel
- Rolando Molina - Iladio
- Christopher Darga - Police Officer
- Tricia Dong - Veterinarian
- Lester Speight - Wrestler
- George Coe - Herb
- Marco Gould - Mitchell
- Michael Halpin - Gerald
- Michael Kostroff - Alan
- Thea Mann - Sue
- Rick Zieff - Arthur
- Chene Lawson - Rachel
- Judith Moreland - Joyce
- Dixie Carter - Peaches
- Kotoko Kawamura - Mrs. Yamaguchi
- Maggie Palomo - Manicurist
- Eric Ware - Sam
- Chris Thompson
George Hamilton interpreta a Don Rio Sepulveda en la serie.
Alfred Molina interpreta a Jimmy Stiles en la serie.
Sharon Lawrence hace el papel de Donna Stiles.
Stephen Root hace el papel de Gene.
Alexa PenaVega interpreta a Wendy Stiles en la serie.
Kaley Cuoco interpreta a Bonnie Stiles en la serie.
Betty White interpreta a Mitzi Stiles en la serie.
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