- Holly J. Barrett - Samantha Hughes
- Giselle Eisenberg - Sophia Hughes
- Ana Sophia Heger - Lark
- Hunter King - Clementine
- Amarr M. Wooten - Buddy
- Alex Borstein - Linette
- Connor Del Rio - Simon
- Richard Marx - Buddy Daiquiri
- Davis Desmond - Heinz
- Griffin Gluck - Aiden
- Christine Woods - Alex Morandi
- Cassidy Naber - Beverly
- Zander Faden - Dancer (uncredited)
- Nancy Linehan Charles - June
- Leslie David Baker - Gavin
- Abbey DiGregorio - Dianna Jazzelroy
- Anthony Turpel - Max (uncredited)
- Gita Reddy - Principal Jennings
- Jordan Peele - Chad
- Susan Park - Dr. Sally Hong
- Exie Booker - Policeman
- Stacie Greenwell - Delivery Nurse
- Riley Bodenstab - Doug
- Mark Berry - Funeral Home Director
- Cedric Yarbrough - Ellis
- Stephnie Weir - Bernadette
- Rhys Darby - Teddy
- Jordan Black - Hotel Manager
- Billy Malone - Aaron
- Sofia Gonzalez - Waitress
- Brian Jordan Alvarez - Jorge
- Fred Maske - Mover
- Mariano Mendoza - Cutter
- Bokeem Woodbine - Officer Wood
- Jonathan Marballi - Levi
- Taylor Coffman - Helen
- Jean-Christophe Febbrari - Andre
- Alison Rich - Kalliope
- Tonita Castro - Tonita
- Martin Starr - Oscar
- Da'Vine Joy Randolph - Janice
- Ken Marino - Will
- Olivia Sanabia - Kylie
- Bella Shepard - Lexie
- Zylan Brooks - Alpha Mom
- Matt Corboy - Randy
- Kevin Linehan - Randy
- Brandon Gibson - Jonathan
- Norma Michaels - Mrs. Gurney
- Shawn M. Richardz - Lauren
- Martin Mull - Gary Timpkins
- Mark L. Young - Scarecrow
- Alejandro Patiño - Store Owner
- Hector Bucio - Son
- Shaan Sharma - Abraham
- Darsan Solomon - Jake Dawe
- Greg Worswick - Gideon
- Matthew Ryan Michaels - Corn Maze Visitor
- Jon Daly - Steffan
- Richard Voigts - Groaning Man
- Phoebe Neidhardt - Hostess
- Lilan Bowden - Waitress
- Delpaneaux Wills - Paramedic
- J.P. Romano - Healthy Man
- Óscar Núñez - Dr. James Changa
- Jason Rogel - Honus
- Haneefah Wood - Tanya
- Sean Poolman - Darryl
- Donovan Scott - Santa
- Brenda Song - Bonnie
- Marshall Faulk - Marshall Faulk
- Gillian Vigman - Tabitha
- Punam Patel - Kara
- Todd Sherry - Clancy
- Marcus Anderson - Esteban
- Sage Correa - Pete
- Efé - Mona
- Marcus Folmar - Francis
- Nancy Linari - Margaret
- Jean St. James - Judith
- Patrick Brammall - Clinton
- Judilin Bosita - Edie
- Bryan Coffee - Jody
- Brad Grunberg - Jerry
- Michael Shaun Sandy - Trainer
- Noureen DeWulf - Dionne
- Amanda Lund - Corky
- Kenny Cooper - Delivery Man
- Greg Grunberg - Mikey
- Ann Morgan Guilbert - GiGi
- Jill Johnson - Keifer's Mom
- Rawle D. Lewis - Pharmacist
- Kai Scott - Mario
- Josh Groban - Ian
- Kat Von D - Lois
- Jordan Danger - Host
- Lola Blanc - Girl
- Andrew Patrick Ralston - Chip Baggins
- Mercedes Ruehl - Mia
- Mary Scheer - Marta Pigeon
- Jackie Seiden - Diora
- Morgan Walsh - Lisa
- Jenn An - Ashley
- Nanrisa Lee - Valerie
- Stephanie Maura Sanchez - Melissa
- Kelly Albanese - Kelly
- Pam Trotter - Pam
- Pam Trotter - Shannon
- Alek Cole - Irving Rosenblatt
- Mimi Karsh - Dancer
- Lars Slind - Ronald
- Kristen Endow - Mall Patron
- Johnny Meyer - Neighbor on Sidewalk
- J.B. Smoove - Darryl
- Ayden Mayeri - Tulip
- Gregg Sulkin - Jake
- Amy Hill - Principal Bundy
- J. Michael Evans - Travis
- Jerry Lambert - Chase
- Fortune Feimster - Dougie
- Meera Rohit Kumbhani - Milly
- Jason Heymann - Prince Charming
- Anthony Holiday - Coach Murray
- Michelle Ortiz - Vanda
- Kotaro Watanabe - Asian Businessman
- Caroline Aaron - Karyl
- Nora Dunn - Carol
- Damian Gomez - Huber
- Megan Mullally - Mary-Lynn
- Nick Offerman - Spencer
- Leith M. Burke - Dr. Casey Dia
- Russell Peters - Dr. Tak Oh
- Lucas Hazlett - Griff
- Angela Malhotra - Nurse Sylvie
- Carla Renata - Physician's Assistant
- Michael Strassner - Head Wound Guy
- Mo Welch - Barista
- Wallace Shawn - Samuel
- Julio Oscar Mechoso - Coach Kip
- Matt Murray - A.J.
- Wayne Federman - Dr. Saul Antro
- Frank Birney - Stan
- Phillip Jordan - Photographer
- Garrett Nichols - Resident
- Jeris Poindexter - Resident
- Toni Torres - Nurse
- Ruben Vernier - Josh
- Debra Wilson - Leigh
- Karen Lew - Matilda
- Antonimar Murphy - Vicki
- Cary Elwes - Professor Sinclair Wilde
- Anahi Bustillos - Sandie
- Sheila Carrasco - Beth
- Lana McKissack - Female Student
- Alex Skinner - Male Student
- Travina Springer - Joss
- Victor Ortiz - Troy
- Calvin Tenner - Waiter
- Vaia Zaganas - Boxer
- Jeff Probst - Jeff Probst
- Patrick Cronen - Rudolfo
- Nancy Nave - Producer
- Lilly Singh - Amanda
- Drew Droege - Chris Joestalli
- Kandee Johnson - YouTube Star
- Sujata Day - Hostess
- Skylar Gray - 5-Year-Old Samantha
- Andy Richter - Julius Black
- Isabella Revel - Georgette
- Michael Cognata - Realtor Don
- Kurt Warner - Kurt Warner
- Malika Williams - Stadium Representative
- Bob Wiltfong - Football Fan
- Kim Yarbrough - Salesperson
- Annie Sertich - Tittianna
- Christopher Avila - Riley
- Mike Monteleone - Old Man in Supermarket
- Deb Snyder - Turkey Meatball Lady
- Molly Shannon - Allie
- Angela Kinsey - Ruth
- Charlie Puth - Charlie Puth
- Lyle Lovett - Ned Gawler
- Brenda Ballard - Miriam Bickle
- Jermaine Jacox - Security Guard
- Michael Lanahan - Dr. Nopunn
- Ashli Haynes - Waitress
- Jeff Houkal - Security Guard
- Tracy Weisert - Doris
- Ty Barnett - Dabney
- Susan James Berger - Mrs. Gerber
- Denell Johnson - Security Officer
- Jessica Jones - Another Woman
- Jillian Peterson - Woman
- Todd Sandler - Train Operator
- Christopher Cho - UPS Guy
- Beth Crosby - Deb
- Marnie Crossen - Sue
- Dutch Johnson - Frank
- Ruby Matenko - Clare
- Daniel Zacapa - Miguel
- Artemis Pebdani - Gittel
- Duncan Calladine - Waiter
- Amrita Dhaliwal - Mom
- Marla Mindelle - Candace
- Anne Stedman - Sangria
- Kerry Stein - Rabbi David
- Jean Villepique - Mrs. Sandoval
- Stone Eisenmann - Roger
- Gabrielle Skye Goodman - Zelda
- Taylor Mosby - Gracie
- Majandra Delfino - Marsha
- Kiva Jump - Patty
- Arianna Ortiz - Irene
- Brian Baumgartner - Dean
- Bianca Haase - Clarinda
- Peter Banifaz - TSA Agent Klein
- Mark Beltzman - Max
- Tammy Dahlstrom - Gate Agent Klugman
- Keeshan Giles - TSA Agent Lasman
- Suzanne Gutierrez - Gate Agent Shattuck
- Cynthia Rose Hall - Gate Agent Blum
- Ravi Naidu - Gate Agent Croom
- Nicole Pettis - Ticket Agent Madison
- Daryl Wein - Elijah
- Matthew Isaac Harris - Passenger
- Leslie Jordan - Neils
- Tatiana Carr - Receptionist
- Frank Crim - Art Sturgeon
- Robert Michael Lee - Salesman
- Fatimah Taliah - Fire Marshal Mull
- Rosalie Vega - Tanya
- Vishesh Chachra - Marcus
- Andy Buckley - Paul
- Julie Chen Moonves - Rose
- Sherry Cola - Cutter
- Marypat Farrell - Renegade
- David Haley - Hal
- Phil Idrissi - Henry
- Maurice Webster - Jamie
- Ajay Mehta - Dr. Patel
- Padma Lakshmi - Stephanie
- Kat Purgal - Employee
- Zach Reino - Class Member
- John Funk - Golfer
- Lynn Adrianna - Frazzled Mom
- Giuliana Carullo - Ayana
- Chip Chinery - Dustin
- Matt Cornett - Ryan
- Angela Fornero - Salesperson
- Stevens Gaston - Bartender
- Arvin Lee - Gabe
- Paul F. Tompkins - York
- Anne Bedian - Waitress
- Tema Louise Sall - Automated Voice (voice)
- Tema Louise Sall - Toy Potty (voice)
- Tema Louise Sall - Art Instructor
- Shay Ali - Mario
- Becki Dennis - Lyft Driver
- Jim Nantz - Football Announcer
- Bardia Seiri - Corbin
- Conroe Brooks - Toy Volunteer
- Sarah Chang - Passerby
- Reatha Grey - Volunteer
- Nick Thune - Finn Jazzelroy
- Lauren Lapkus - Cindy
- Mindy Sterling - Desiree
- Bunny Gibson - Nancy
- Jess Harnell - Dr. Hoot-Stein
- Mary-Margaret Lewis - Elderly Woman
- André B. Walker - Mike
- Alex Boling - Telemarketer (voice)
- Adalgiza Chermont - Jacquelyn
- Nicola Lambo - Natasha
- John Shelton - Doug E. Howser
- Emily C. Chang - Donna
- Dana Schick - Hailey
- Chad Yazawa - Delivery Man
- Joanna Cassidy - Charlotte Collins
- Fred Melamed - Dr. Dave Collins
- Brian Van Holt - Wayne Winger
- Aleksei Archer - Austin / PookieGunner
- Betsy Baker - Emcee
- Juliet Tondowski - Sandy / BedBathAndBeyonce
- Tony Cavalero - Dale
- Christian Anderson - Mr. Pickle (voice)
- Leslie Carrara-Rudolph - Monkey (voice)
- Alissa Hunnicutt - One-Eyed Bear (voice)
- Donna Kimball - Susan B. Anthony (voice)
- Tim Lagasse - Shark (voice)
- Joey Mazzarino - Mr. Lobster (voice)
- Cassandra Relynn - Police Officer
- Gregory A. Thompson - Passerby
- Jade Catta-Preta - Rita
- Zack Pearlman - Dusty
- Maahra Hill - Mother
- Meredith Roberts Quill - Cheryl
- Joanna Sotomura - Jordana
- Sheaun McKinney - Erikson
- Cyrina Fiallo - Mavis
- Ellen D. Williams - Shelley
- Lainee Rhodes - Student
- John Brotherton - Wyatt
- Kate Miner - Lindsay
- Shalini Bathina - Waitress
- Edith Fields - Marlene
- Dan Sachoff - Air Traffic Controller
- Nicky Whelan - Kaeli
- Kyle Erby - Husband
- Callie Gilbert - Chelsea
- Camila Greenberg - Kim
- Hal Alpert - Bill
- Ben Bowen - Christian
- Amanda Westlake - Hillary
- Brad Morris - JP
- Luis Avila - Anthony
- Keana Marie - Lala
- Trujo - Rodrigo
- Chelsea Vincent - Maria
- Nat Faxon - Hayes
- Joey King - Morgan
- Carla Jimenez - Sherri
- Miles Dausuel - Engineer
- Kayvon Esmaili - Bradford
- Kate Gilligan - Poppy
- Nicholas Walker - Guitarist
- Lisa Brenner - Skylar
- Swati Kapila - Claire
- Kate Berlant - Eliza
- Jill Bartlett - Sasha
- Sachie Alessio - Doctor Gwen Chilada
- Maria Pallas - Imogen
- Krishna Smitha - Alissa
- Biff Wiff - Mr. Sissel
- Pyper Braun - Blonde Girl
- Larry Herron - Officer Torte
- John Shartzer - Bear
- Brennan Mejia - Magician Clown
- Carlos Ragas - Romantic Clown
- Mindy Montavon - Magician Assistant Clown
- Sarah Baker - Eve
- Risa Dorken - Elle
- Claudia Choi - Dr. Feld
- Ray Reynaga - Utilities Worker
- Paul Dooley - Mort
- Carol Herman - Betty
- David Bickford - Dr. Tom Alles
- John Eddins - Dr. H. Ardshell
- Chieko Hidaka - Hostess
- Sara Montez - Nurse
- Mary Pat Gleason - Edna
- Richard Kind - Stuart
- Joni Bovill - Principal Moore
- Christina Ferraro - Karen
- Maisie Klompus - Amber
- Isabella Grosso - Dancer
- Evan Agos - Miscellaneous (Other) Crew (voice)
- Eddie Diaz - Police Officer
- Rebecca Asher
- Helen Hunt
- Jaffar Mahmood
- Ken Whittingham
- Marcus Stokes
- Melissa Kosar
- Jason Belleville
- Barbie Adler
- Ilana Wernick
- David Monahan
- Kyle Mack
- Kirker Butler
- David Greditzer
Joanna Cassidy interpreta a Charlotte Collins en la serie.
Cary Elwes interpreta a Professor Sinclair Wilde en la serie.
Caroline Aaron interpreta a Karyl en la serie.
Mercedes Ruehl interpreta a Mia en la serie.
Nora Dunn interpreta a Carol en la serie.
Thomas Sadoski interpreta a Matt Short en la serie.
Dianne Wiest interpreta a Joan Short en la serie.
James Brolin interpreta a John Short en la serie.
Zoe Lister-Jones interpreta a Jen en la serie.
Colin Hanks hace el papel de Greg Short.
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