- Renée Taylor - Sylvia Fine
- Lainie Kazan - Aunt Freida
- Céline Dion - Celine Dion
- Joyce Brothers - Dr. Joyce Brothers
- Michael McKean - Professor Noel Babcock PhD
- Dina Merrill - Elizabeth Sheffield
- Jane Seymour - Jane Seymour
- Blanche Rubin - Old Lady
- Ian Buchanan - Jules Kimball
- Burt Bacharach - Burt Bacharach
- Corbin Bernsen - Glen Mitchell
- Roger Kern - Raymond Turnboat
- Catherine Oxenberg - Sydney Mercer
- Donna Dixon - Monica Baker
- Derek Webster - Reporter
- Harry Hamlin - Professor Steve
- Donna Douglas - Donna Douglas
- Ray Charles - Sammy
- Efrem Zimbalist Jr. - Theodore Timmons
- Lorne Michaels - Barbra Streisand
- Burke Moses - Tony Tatorri
- Liz Smith - Liz Smith
- Brenda Ballard - Woman At The Park
- Bryan Kirkwood - Maggie's Boyfriend
- Steve Blackwood - Doctor
- Diane Baker - Roberta
- Anthony Cistaro - Carlo
- Candy Trabuco - Lexine
- Dayton Callie - The Sergeant
- Billy Ray Cyrus - Billy Ray Cyrus
- Brian George - Butler Inspector
- Eric Braeden - Frank Bradley
- Marvin Hamlisch - Alan Neider
- Paolo Seganti - Philippe
- Mark Chaet - Hotel Valet
- Anne Lambton - Madeline Porter
- Lila Garrett - Lady in Ladies' Room
- Thomas Dekker - J.B. Bingington's Son
- Gloria Gifford - INS Officer
- Judith Hoag - Kathy Marie O'Malley / Katherine Porter
- Honey Lauren - Waitress
- Ron Melendez - Peter Bidwell
- Gabriel Bologna - Dr. Taylor
- Cristine Rose - Dr. Voort
- Peggy Blow - Nanny
- Rosie O'Donnell - Cozette
- Wallace Shawn - Charles Haste
- Leigh Lawson - Lester
- Benjamin Kimball Smith - Brighton's Friend
- Wayne C. Dvorak - Waiter
- Alex Trebek - Alex Trebek
- Milton Berle - Uncle Manny
- Philip Casnoff - Cantor Gary Isaacs
- Ray Abruzzo - Chopper Pilot
- Dakin Matthews - Dean Sterrett
- Howie Mandel - Howie Mandel
- Jason Andrews - Guard
- David Letterman - David Letterman (uncredited)
- Alex Nevil - Mugger
- Ron Orbach - Barry Cooperman
- Kort Falkenberg - Priest
- Jeff Mooring - Waiter
- Gabrielle Boni - Erica
- Scott Whyte - Sean
- Bob Goen - Bob Goen
- Sophie Ward - Jocelyn Sheffield
- Barbara Howard - Fertility Doctor
- Richard Kind - Jeffrey Needleman
- Richard Portnow - Phillipe
- Gregg Rogell - Kenny Keroucan
- Ian Abercrombie - Butler Inspector
- Nick Salamone - Reporter
- Charlie Newmark - Dr. Hamilton
- Zack Norman - Uncle Jack
- Tim Lounibos - Mark
- James McDonnell - Colin
- Edward Penn - Richard Porter
- Ralph Manza - Saul
- Blake McIver Ewing - Robby
- Martha Gehman - Betty
- Jackie Tohn - Tiffany Koenig
- Lane Davies - Nigel Waters
- Sally Jessy Raphael - Sally Jessy Raphael
- Christopher Rich - Kurt Jacobs
- Irene Olga López - Lupe
- Liza Stanley - Reporter
- William Bumiller - Detective Schoenfeld
- Margaret Cho - Caryn
- Andrew Levitas - Michael
- Ellen Ratner - Nadine Cooperman
- Shari Lewis - Shari Lewis
- James Marsden - Eddie
- Louis Guss - Irving Koenig
- Aaron Heyman - Man at the Movie
- Morgan Brittany - Judy Silverman
- Andy Dick - Pepé / Bernie
- Matt McCoy - Steve Mintz
- Patti LaBelle - Patti LaBelle
- Bob Barker - Bob Barker
- Tyne Daly - Mona
- Jack Knight - Doorman
- Nancy Frangione - Marsha
- Michael Winters - Doug Emerson
- Ray Stricklyn - Wendell Kent
- Burke Roberts - Photographer
- Maxwell Caulfield - Rodney Pembroke
- Jake Richardson - Willie
- Miriam Flynn - Country Club Manager
- Coolio - Coolio
- Coolio - Irwin
- DeeDee Rescher - Dottie
- DeeDee Rescher - Bridal Shop Clerk
- Robert Culp - Stewart Babcock
- Adam Hendershott - Kevin
- Kellen Hathaway - Bernard
- Magda Harout - Sarah
- Magda Harout - Madam Moleska
- George Murdock - Dakota Williams
- Andy Mackenzie - Repairman
- Rita Rudner - Margot
- Ben Vereen - Ben Vereen
- Eydie Gormé - Eydie Gormé
- Darryl Hickman - Priest
- Dorothy Lyman - Maureen Wentworth
- Dorothy Lyman - Dr. Quinn Director (voice) (uncredited)
- Twiggy - Jocelyn Sheffield
- Nancy Linari - Mrs. Livingston
- Stephen Nichols - Brock Storm
- Marji Martin - Nanny Bower
- Marion Ramsey - Woman in Audience
- Jonathan Penner - Danny Imperiali
- Chad Everett - Dr. Osborn
- Lauren Tom - Kim
- Lu Leonard - Nanny
- Lawrence Mandley - Orderly
- Lawrence Mandley - Policeman
- Lesley-Anne Down - Chloe Simpson
- Dean Tarrolly - David Stavros
- Jay Robinson - The Maitre'd
- Lauren Koslow - C.C.'s Friend
- Marilyn Cooper - Grandma Nettie
- Nora Dunn - Dr. Reynolds
- Nikki Cox - Cindy Wentworth
- Marianne Muellerleile - Andrea's Mother
- Joseph Bologna - Dr. Joe Razzo
- Joseph Bologna - Alan Beck
- Sherman Augustus - Doorman
- Dona Hardy - Sister
- Timothy Watters - President Bill Clinton
- Roger Clinton, Jr. - Roger Clinton
- Bonnie Morgan - Brooke
- Nancy Lenehan - Russian Woman
- Fritzi Burr - Woman at the Movie
- Steven Anderson - Doctor
- Tracy Nelson - Mary Ruth
- Pamela Dillman - C.C.'s Friend
- Allen Bloomfield - Uncle Myron
- Miko Hughes - Frank Bradley Jr
- Rita Moreno - Mrs. Wickervich Stone
- Cloris Leachman - Clara Mueller
- Scott Baldyga - Hotel Clerk
- Lynn Redgrave - Lynn Redgrave
- Caroline Rhea - Caroline Rhea
- Chuck Mavich - Pizza Delivery Guy
- Michael C. McCarthy - David
- Erik Estrada - Erik Estrada
- George Coe - Ernest
- Maree Cheatham - Emma Trusdale
- Lisa Alpert - Maid in 'Royal Flush'
- Allan Rich - Pauly the Pawnbroker
- Allan Rich - The Judge
- Christina Pickles - Nurse
- Patrick Cassidy - Mr. Anthony
- Barry Watson - Greg (uncredited)
- Leann Hunley - Bobbi Jo
- Francesca P. Roberts - Nurse Smith
- Richard Roat - Santa Claus
- Linda Harmon - Solo singer (voice) (uncredited)
- Susan Krebs - Headmistress
- Bruce Vilanch - Bruce Vilanch
- Jamie Renée Smith - Young Fran Fine
- Tawny Moyer - Nurse
- Ellen Albertini Dow - Wendell Kent's Mother (uncredited)
- Anne Betancourt - Doctor
- Carol Channing - Carol Channing
- Bob Clendenin - The Bum
- Dan Aykroyd - Repair Man (uncredited)
- Edward Hibbert - Claude
- Pete Leal - Cleaning Man
- Bess Armstrong - Sara Sheffield (uncredited)
- Fred Stoller - Fred, the pharmacist
- Nancy Cassaro - Libby
- Steve Lawrence - Morty Fine
- Steve Lawrence - Steve Lawrence
- Mark Newsom - 'Crab Cake' Waiter (uncredited)
- Tom Bergeron - Tom Bergeron
- Lorna Luft - Cousin Susan
- Hal Linden - Maury Sherry
- Amy Tolsky - Singer
- Tacey Adams - Hollywood Squares Contestant
- Ryan McPartlin - Performer
- Chris Bruno - Ski Instructor
- Martin Mull - Martin Mull
- Christopher Marquette - Young Maxwell Sheffield
- Alissa Dowdy - Dunson Twin
- Peter Marc Jacobson - Man at the Bar
- Peter Marc Jacobson - Man Exiting Restroom with Fly Open (uncredited)
- Peter Marc Jacobson - Romeo Actor
- Estelle Getty - Estelle Getty
- Renee Cohen - Young Yetta
- Joe Lando - Joe Lando
- Morty Drescher - Uncle Stanley
- Morty Drescher - Male Patient (uncredited)
- Morty Drescher - Morty Fine
- Chris Elliott - Chris Malley
- Chester Drescher - Chester Babcock (uncredited)
- Chester Drescher - The Chester
- Saemi Nakamura - Mrs. Fu
- Helen Geller - Singer
- Dennis Dun - Doctor Fu
- Jennifer Edwards - Society Woman #2
- Jane Sibbett - Marcy Feldman / Morgan Faulkner
- J. Madison Wright - Betty Jo
- Pamela Anderson - Heather Biblow-Imperiali
- Roseanne Barr - Cousin Sheila
- Elton John - Elton John
- Whoopi Goldberg - Whoopi Goldberg
- Whoopi Goldberg - Edna
- Sylvia Drescher - Female Patient (uncredited)
- Sylvia Drescher - Aunt Rose (archive footage) (uncredited)
- Sylvia Drescher - Aunt Rose
- Chevy Chase - Chevy Chase
- Jennie Kwan - Mai Ling
- Michael Bolton - Michael Bolton
- Scott Baio - Dr. Frankie Cresitelli
- Joan Van Ark - Margo Lange
- Marla Maples - Marla Maples
- Roslyn Kind - Roslyn Kind
- Tia Riebling - Mother in the Park
- Peter Scolari - Leslie Tilbert
- J.D. Daniels - Mimo
- J.D. Daniels - Jack Walker
- Joan Collins - Joan Sheffield
- Robert Vaughn - James Sheffield
- Elizabeth Taylor - Herself
- Donald O'Connor - Fred
- Athena Ashburn - Chatterbox Cosmetologist
- Anthony Addabbo - Mike LaVoe
- Fran Drescher
- Peter Marc Jacobson
Marianne Muellerleile hace el papel de Andrea's Mother.
George Murdock interpreta a Dakota Williams en la serie.
Elizabeth Taylor hace el papel de Herself.
Whoopi Goldberg hace el papel de Edna.
Fran Drescher hace el papel de Fran Fine.
Nora Dunn interpreta a Dr. Reynolds en la serie.
Richard Portnow interpreta a Phillipe en la serie.
Dan Aykroyd interpreta a Repair Man (uncredited) en la serie.
Chris Elliott interpreta a Chris Malley en la serie.
Charles Shaughnessy interpreta a Maxwell Sheffield en la serie.
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