- Jack Jones - Lewin
- Jo Van Fleet - Irini Karabetas
- Lynn Loring - Janet Richards
- Lucille Benson - Aunt Benjamin
- Jack Ging - Capt. Harris
- Pamela Franklin - Karen Vaughn
- Michael Lerner - Ralph Guidera
- Juliet Mills - Amy Hollis
- John Crawford - Capt. Parks
- Pat Carroll - Miriam Stein
- Earl Boen - Myron
- Tige Andrews - Lieutenant McKay
- Eartha Kitt - Black Amelia
- Virginia Gregg - Astrid
- Joe E. Tata - Blat
- Monte Markham - Joey Marr / Carl Rossi
- William Shatner - Mark Ciprio
- Kenneth Mars - Manny Ziegler
- Diana Muldaur - Helen Murphy
- Ned Romero - Gomez
- Cliff Emmich - Ronald English
- Cliff Emmich - Spiro
- Barry Livingston - Eric Miller
- Sid Haig - Denver
- Mark Harmon - Stanski
- Frank De Kova - Vito Angelo
- James Darren - Rick Matteo
- Rick Jason - Lambkee
- Rick Jason - Vincent Phillips
- Rick Jason - James Basterie
- Robyn Hilton - Trudy
- Bradley Lieberman - Scott
- William Whitaker - Murray
- Lisa Reeves - Coed #2
- Lisa Reeves - Girl
- Bruce Boxleitner - Ed Krohl
- William Windom - Ted Adrian
- Sherry E. DeBoer - Cindy (as Sherry Miles)
- Bert Williams - Karel
- Betty Kean - Charlene's Landlady
- Phillip Terry - Landon
- Med Flory - Tour Driver
- Bob Crane - Larry Brooks
- Della Reese - Tina Thompson
- Alberto Morin - Maitre'D
- Robert Sampson - Mickey Ross
- Allen Case - Fritz
- Arlene Golonka - Carolee English
- Paul Burke - Joe Fenner
- Antonio Fargas - Rex
- Paula Kelly - Linda Summers
- Val Bisoglio - Lt. Marsh
- James Murtaugh - Sanford Elliott
- Robert Vaughn - Andrew Simms
- Elinor Donahue - Ellie Tarlow
- William Katt - Martin Wadsworth
- Robert F. Simon - Dr. Foreman
- Joan Darling - Therese Russo
- John Larch - Lester Hummel
- Dick Miller - Matt
- Monte Landis - Nadje
- Monte Landis - The Snitch
- Rhonda Fleming - Carol Grainger
- Pat Morita - Mike Matsuto
- Sharon Farrell - Hallie
- Sharon Farrell - Marcia Gordon
- Jack Riley - Joe
- Don 'Red' Barry - Captain Barnes
- Don 'Red' Barry - Captain Simmonds
- Don 'Red' Barry - Ted
- Don 'Red' Barry - Capt. Red Barnes
- Don 'Red' Barry - Capt. Barnes
- Don 'Red' Barry - Lt. Bocina
- Don 'Red' Barry - Morris
- James Karen - Driver
- Richard Kelton - Ron Chamberlin
- Priscilla Pointer - Adele French
- Ann Robinson - Mrs. Green
- Joyce Bulifant - Peggy Lakes
- Jamie Donnelly - Monica / Jan
- Alex Cord - Bass
- Kaz Garas - Frankie Benson
- Charles Bateman - Fred Boyle
- Charles Bateman - Dan Benedict
- France Nuyen - Millie
- Lance LeGault - Bill Klein
- Lance LeGault - Lench
- Lance LeGault - Dennis Graham
- Art Evans - Russ Singer
- John Mahon - Fireman
- Darrell Zwerling - Harry Kubelski
- Darrell Zwerling - Wilkes
- Gary Graham - Santa
- Teddy Wilson - Tommy Thompson
- Teddy Wilson - Harold Martin
- Harold J. Stone - Rolf
- Charlie Brill - Di Marco
- Henry Darrow - Gomez
- Jean Allison - Superintendent Marla
- Carole Mathews - Deputy Ruth
- Florence Lake - Mrs. Farrell
- Elizabeth Kerr - Mrs. Edgeworth
- Dick Balduzzi - Mr. Torson
- Garry Walberg - Mr. Lund
- Vince Howard - Det. Johnson
- Don Stroud - Bobbo Olchin
- Don Stroud - Vern Lightfoot
- Charles Seel - Older Man
- Sam Elliott - Michael Gregory
- Ryan MacDonald - Mr. Green
- Ryan MacDonald - Jonas Van Dyke Jr.
- Geoffrey Lewis - Officer Akers
- Geoffrey Lewis - Vern Spear
- Geoffrey Lewis - Gates
- Loni Anderson - Waitress
- Anthony George - Tony Linaver
- Bond Gideon - Dolores
- Steve Franken - Clerk
- Michael Burns - Danny Powers
- Louis Nye - Myron Drew
- Foster Brooks - Darryl Everson
- Jacqueline Scott - Kathleen
- Craig Stevens - Saunders
- Carol Lynley - Nina Daniels
- Edward Binns - John Solvana
- Pat Crowley - Marlene Simpson
- Charles Cooper - the Chairman
- Edd Byrnes - Billy Dodge
- Audrey Christie - Mamie
- Raymond St. Jacques - Alex Steeves
- Glenn Corbett - Jerry Woolard
- Ron Masak - Pincus
- Thaao Penghlis - Intern
- Robert Loggia - Paul Nicastro
- Robert Loggia - Sylvester
- George Murdock - Macon
- George Murdock - Hogan
- Robert Emhardt - The Apartment Manager
- Joanna Pettet - Glenna Burns / Beth Lord
- Robert Webber - Julian Lord
- Brian Dennehy - Burrows
- Mario Gallo - Hotel Clerk
- Cynthia Sikes - Michelle
- Charles Haid - Charley French
- Read Morgan - Yavich
- Read Morgan - Jake
- Read Morgan - Car-Wash Attendant
- William Lucking - Charlie Joe Lightfoot
- Bob Harks - Casino Patron (uncredited)
- Bob Harks - Policeman (uncredited)
- Ethelreda Leopold - Casino Patron (uncredited)
- David Gerber
Michael Lerner interpreta a Ralph Guidera en la serie.
Elinor Donahue interpreta a Ellie Tarlow en la serie.
William Shatner interpreta a Mark Ciprio en la serie.
Bruce Boxleitner interpreta a Ed Krohl en la serie.
Angie Dickinson interpreta a Sgt. Suzanne 'Pepper' Anderson en la serie.
Earl Holliman interpreta a Lt. Bill Crowley en la serie.
Charles Dierkop hace el papel de Det. Pete Royster.
Ed Bernard interpreta a Det. Joe Styles en la serie.
Susan Gailey hace el papel de Rosie.
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