- Marc Evan Jackson - Wallace Faulkner
- Glenn Close - The Woman in Seat 2A (uncredited)
- Jim Rash - Flight Attendant
- Benjamin Levy Aguilar - Rex
- Michael Heidemann - Wedding Guest Waiter (uncredited)
- Maria Russell - Beth Halloran
- Andrew Friedman - Warden
- Phil LaMarr - Group Counseling Leader
- Rachel Ramras - Eileen
- John Hill - Jamie Jackson
- Christopher Chen - Michael
- Tim Bagley - School Official
- Lyndon Smith - Ms. Patrick
- Nitya Vidyasagar - Hilary Lathan
- Eve Sigall - Old Woman
- Kelly Chavers - Teacher
- Kiel Kennedy - Stripper
- Karen Y. McClain - Margaret
- Timothy Davis-Reed - Man in Nice Sweater
- David Murrietta Jr. - AA Attendee (uncredited)
- Larry Dorf - Officer Spitz
- Michael Hitchcock - Paul M. Riordan
- Daniele Gaither - Correctional Officer
- Steve Little - Prisoner
- Caroline Anna-Kaye Green - Wedding Guest (uncredited)
- Samsara Yett - Emma
- Brenda Koo - Carol
- Appy Pratt - Elizabeth
- Shelley Hennig - Lisa
- Brendan Jennings - Massacre Mike
- Christina Anthony - Detective Lane
- Janina Gavankar - Meredith
- Nicole Pulliam - Claire
- Michael Lehmann
- Kristen Bell
- Jessica Elbaum
- Will Ferrell
- Hugh Davidson
- Brittney Segal
- Rachel Ramras
- Todd Beckett
- Nami Melumad
Glenn Close interpreta a The Woman in Seat 2A (uncredited) en la serie.
Kristen Bell interpreta a Anna en la serie.
Tom Riley hace el papel de Neil.
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