- Ruta Gedmintas - Serafina Pekkala
- Jamie Ward - Father Gomez
- James McAvoy - Lord Asriel
- Lin-Manuel Miranda - Lee Scoresby
- Jade Anouka - Ruta Skadi
- Lia Williams - Dr Cooper
- Will Keen - Father President MacPhail
- Will Keen - Father/Cardinal MacPhail
- Will Keen - Father MacPhail
- Ian Gelder - Charles
- Philip Goldacre - Sub-Rector
- Richard Cunningham - Chaplain
- Patrick Godfrey - Butler
- Libby Rodliffe - Lyuba (voice)
- Sandra James-Young - Diane
- Simon Manyonda - Benjamin De Ruyter
- Nabil Elouahabi - The Bright-Eyed Man
- Phoebe Scholfield - Alicia (voice)
- Harry Melling - Sysselman
- Geoff Bell - Jack Verhoeven
- Tyler Howitt - Billy Costa
- Kate Rutter - Sister Betty
- Raffiella Chapman - Annie
- Pasi Antero Remsu - Samoyed Hunter
- Amit Shah - Dr. Rendal
- Georgina Campbell - Adele Starminster
- Morfydd Clark - Sister Clara
- Joi Johannsson - Iofur Raknison
- Mat Fraser - Raymond Van Gerrit
- Asheq Akhtar - Jotham Santelia
- Peter Serafinowicz - Iofur Raknison (voice)
- Robert Emms - Thomas
- Clarke Peters - The Master
- Marama Corlett - Katja Sirkka
- Ian Peck - Cardinal Sturrock
- Sope Dirisu - Sergi (voice)
- Gary Lewis - Thorold
- Johanne Murdock - Alanna Perkins
- Jane How - Annabel Parry
- Brian Protheroe - Graham Parry
- Nina Sosanya - Elaine Parry
- Angus Wright - Dr. Haley
- Jamie Wilkes - Pale Faced Man
- Henry Miller - Porter
- Kirsty Besterman - Sam Cansino
- Nigel Cooke - Seal Hunter
- Frankie Hervey - Louise
- Alfie Todd - Ben
- Kit Connor - Pantalaimon (voice)
- Helen McCrory - Stelmaria (voice)
- David Suchet - Kaisa (voice)
- Joe Tandberg - Iorek Byrnison (voice)
- Cristela Alonzo - Hester (voice)
- Remmie Milner - Lena Feldt
- Sophie Okonedo - Xaphania (voice)
- Sasha Frost - Reina Miti
- Terence Stamp - Giacomo Paradisi
- Phoebe Waller-Bridge - Sayan Kotor (voice)
- David Langham - Father Garret
- Robin Pearce - Oliver Payne
- Omid Djalili - Dr. Martin Lanselius
- Sean Gilder - Father Graves
- Lewis MacDougall - Tullio
- Julie Hale - Zoe (Mary's Sister)
- John MacNeill - Security Guard
- Frank Bourke - Fra Pavel
- Ray Fearon - Mr. Hanway
- Lindsay Duncan - Octavia (voice)
- Bella Ramsey - Angelica
- Martin Bell - Father Jerome
- Seán Carlsen - Townsman
- Marged Esli - Elderly Woman
- Lauren Grace - Joseph
- Sorcha Groundsell - Maddy
- Andrew Scott - John Parry
- Andrew Scott - Colonel John Parry
- Andrew Scott - Jopari
- Gerald Tyler - Senior Priest
- Victoria Hamilton - Stelmaria (voice)
- Wade Briggs - Archangel Alarbus
- Aisha-May Hunte - Asriel's Soldier
- Naomi Battrick - Death Lyra
- Souad Faress - Larissa
- Mark Holden - Customs Officer Alexander
- Gerard Horan - Bureaucrat Nemo
- Jamie Kenna - Peter
- Peter Wight - Boatman
- Kate Ashfield - Atal (voice)
- Sophie Brooke - Ghost Sally
- Ellie-Mae Siame - Ghost Sophia
- Jake Siame - Ghost Simon
- Flip Webster - Ghost Hannah
- Emma Tate - Harpy (voice)
- Annabel Hill - Ghost Alice
- Robert Boulter - Lucas
- Francis Lovehall - Samuel
- Patricia Allison - Kirjava (voice)
- Tuppence Middleton - Father Gomez's Daemon (voice)
- Simon Harrison - Baruch
- Sian Clifford - Agent Salmakia
- Alex Hassell - Metatron
- James Cosmo - Farder Coram
- Lucian Msamati - John Faa
- Anne-Marie Duff - Ma Costa
- Daniel Frogson - Tony Costa
- Kobna Holdbrook-Smith - Balthamos
- Kahleen Crawford
- Julie Gardner
- Jack Thorne
- Basia Lalik
- Carolyn Blackwood
- Toby Emmerich
- Lorne Balfe
Sophie Okonedo hace el papel de Xaphania (voice).
James Cosmo interpreta a Farder Coram en la serie.
Gary Lewis interpreta a Thorold en la serie.
Patrick Godfrey hace el papel de Butler.
Dafne Keen interpreta a Lyra Silvertongue en la serie.
Amir Wilson interpreta a Will Parry en la serie.
Ruth Wilson hace el papel de Mrs Coulter.
Adewale Akinnuoye-Agbaje hace el papel de Ogunwe.
Simone Kirby interpreta a Mary Malone en la serie.
Will Keen hace el papel de Father President MacPhail.
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