- Pamela Adlon - Fanny Mudman
- Dove Cameron - Anastasia Romanov
- Danny DeVito - Czar Nicholas
- Josh Gad - Shakespeare
- Johnny Knoxville - Rasputin
- Preston Lacy - Jackrasp Russian
- Charles Melton - Josh
- Ana Ortiz - Alexandra Romanov
- Chris Pontius - Jackrasp Russian
- Nick Robinson - Robert Todd Lincoln
- Will Sasso - Fred
- Jason 'Wee Man' Acuña - Jackrasp Russian
- Sarayu Blue - Publisher
- Parvesh Cheena - Publisher
- Lisa Gilroy - Romanov Daughter / Eva Braun
- Ayden Mayeri - Cavewoman
- Natalie Morales - Cavewoman
- Paul Scheer - Bot Seed Vendor
- Andrew Secunda - Joseph Goebbels
- James Adomian - Richard Nixon
- Ronny Chieng - Kublai Khan
- Colton Dunn - Conrad Chisholm
- Jay Ellis - Jesus
- Marla Gibbs - Ruby Seale
- Anna Maria Horsford - Mother Mary
- Jake Johnson - Marco Polo
- Richard Kind - Peter
- J.B. Smoove - Luke
- James Urbaniak - Roman Soldier
- Kym Whitley - Florynce Kennedy
- Arturo Castro - Private Martinez
- Eugene Cordero - Private Cooper
- Jon Daly - Glenn
- Scott MacArthur - Fleetus
- Tim Baltz - Lieutenant Henry Honeybeard
- Jack Black - Joseph Stalin
- Rob Corddry - Vladimir Lenin
- Zahn McClarnon - Private Mingoes
- Drew Tarver - Private Tully
- Drew Tarver - Adolf Hitler
- Guy Branum - Serf Board Vendor
- Guy Branum - Union Soldier
- Wendi McLendon-Covey - Mrs. Federov
- Sam Richardson - Thomas Watson
- Seth Rogen - Noah
- Taika Waititi - Sigmund Freud
- Tyler James Williams - Private Mason Dixon
- Ayo Edebiri - Runaway Slave
- Mitra Jouhari - Cavewoman
- Mitra Jouhari - Sonora
- Mitra Jouhari - Natalia
- Joe Mande - Sergei
- Josh Meyers - General Philip Sheridan
- Jerry Minor - Bolsheviks II Mensheviks Singer
- Rachel Pegram - Japheth's Wife
- Jessica St. Clair - Sarah
- Zazie Beetz - Mary Magdalene
- Quinta Brunson - Martha Magdalene
- Ana Fabrega - Not-a-virgin Sacrifice
- Jenifer Lewis - Grandma
- Fred Armisen - Glorp
- Lance Bangs - Lance
- Alan Barinholtz - Barker
- Travis "Taco" Bennett - Ahmed
- Shelly Desai - 25-Year Old Man
- Morgan Grier - Granddaughter
- Joe Nuñez - Mesoamerican Man
- Brock O'Hurn - Jesus
- Brock O'Hurn - Mel Brooks body double
- Bardia Salimi - Mesoamerican Man
- Edgar Blackmon - Apostle
- Edgar Blackmon - Studio Audience Member
- Edgar Blackmon - Private Johnson
- Timothy Simons - Abraham Lincoln
- Malcolm Barrett - Captain Hanks
- Malcolm Barrett - Idi Amin
- Seth Morris - Ronald Gerbstein
- Seth Morris - Shakespeare Writer
- Seth Morris - Freud's Patient
- Tim Bagley - Doctor
- Craig Cackowski - Joseph Stalin
- Brandon Kyle Goodman - Clay
- David Stassen - Union Soldier
- David Stassen - Sitcom Director
- Andrew Rannells - Sergei the Photographer
- Christopher Thornton - Franklin Roosevelt
- George Wallace - Governor George Wallace
- Josh Fadem - Money Lender
- Josh Fadem - Private Bryant
- Eric Nenninger - German Tourist
- Jason Alexander - Maurice Cheeks
- Hannah Einbinder - Amelia Earhart
- Jack McBrayer - General Robert E. Lee
- Margaret Cho - Sophia
- Bobby Lee - Harold
- Kulap Vilaysack - Jennifer
- Dan Bakkedahl - Winston Churchill
- D'Arcy Carden - Turkey Ambassador
- Andy Cohen - Andy Khan
- Andy Daly - Norway Ambassador
- Kimiko Glenn - Chabi
- Mary Holland - Typhoid Mary
- Gil Ozeri - Joot
- Gil Ozeri - Zakher
- Mousa Kraish - Palestine Ambassador
- Poppy Liu - Ehri
- Owen Burke - Red Sox Fan
- Owen Burke - Boris
- Jason Mantzoukas - Greece Ambassador
- Mena Massoud - Egypt Ambassador
- Crystal Kung Minkoff - Crystal
- Finesse Mitchell - Reverend Jesse Jackson
- Rob Riggle - Roman Soldier
- Carl Tart - Lazarus
- Michaela Watkins - Israel Ambassador
- Fran Gillespie - Bazaar Woman
- Brian Huskey - Watergate Burglar
- Caleb Jeon - Travis
- Sandi McCree - Watergate Receptionist
- Atsuko Okatsuka - Nambui
- Scout Tayui-Lepore - Kayla
- Sophia Tayui-Lepore - Kaylah
- CJ Uy - Travis
- Donisha Walker - Cater Waiter
- Jillian Bell - Focus Group Moderator
- David Duchovny - Howard Cosell Impersonator
- Blake Griffin - Muhammad Ali
- Emily Ratajkowski - Mary Magdalene
- Sarah Silverman - Lieutenantman Silverman
- Casey Wilson - Gloria
- Casey Wilson - Mother Mary
- Neville Archambault - Neville
- Joe Lo Truglio - Red Bishop
- Hayes MacArthur - Mark
- Ken Marino - Bishop
- Gracen Newton - Jesus Fan
- Adam Pally - Judas
- Lennon Parham - German Wallbreaker
- Rosalind Russell - Rosa Parks
- Paul Rust - DNC Worker
- David Wain - Bishop
- Reggie Watts - German Wallbreaker
- Ike Barinholtz
- Kevin Salter
- Mel Brooks
- Nick Kroll
- David Stassen
- Wanda Sykes
Danny DeVito interpreta a Czar Nicholas en la serie.
Ike Barinholtz hace el papel de Various Characters.
Mel Brooks interpreta a Narrator en la serie.
Nick Kroll hace el papel de Various Characters.
Jason Alexander hace el papel de Maurice Cheeks.
Wanda Sykes hace el papel de Various Characters.
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