- Melvyn Douglas - Pat Konke
- Frank Puglia - Guide
- Lee J. Cobb - Ernie Wigman
- Marisa Pavan - Alva
- David Carradine - Fitzhugh
- Arlene Dahl - Valerie
- Carl Banas - Byron James
- Peter Brocco - L-Quar
- Tige Andrews - Det. Owens
- Angie Dickinson - Susan Konke
- Archie Moore - Buddy
- Tony Musante - Major DeGuisado
- Chester Morris - Major Whitman
- Billy De Wolfe - Inspector
- Barbara Rush - Ganoulian
- Jo Van Fleet - Emily Cooper
- Lee Grant - Virginia Cloyd
- Stanley Adams - Vito Conte
- Piper Laurie - Lee Wiley
- Joe De Santis - Albert Ortega
- Sharon Farrell - Melissa
- Paul Fix - Hap Collins
- Len Lesser - Le Bombard
- Dina Merrill - Maralise
- Jane Wyman - Addie Joslin
- Alex Cord - Lucky Paxton
- Mary Wickes - Nurse
- Dick Wessel - Officer
- Nehemiah Persoff - Alverian
- George Peppard - Buddy Wren
- Percy Rodriguez - Detective John Rollins
- Harry Guardino - Rick
- Janis Paige - Self
- Marc Lawrence - Orente
- George N. Neise - Reynolds
- Carroll O'Connor - Lawson
- Carroll O'Connor - Capt. Ted Eyck
- Phyllis Diller - Self
- Andrew Duggan - Donald Guthrie
- Andrew Duggan - Father Michaell
- Gena Rowlands - June
- Larry J. Blake - Metcalf
- John Vernon - Steve Wojeck
- Arte Johnson - Chip Broadwater
- Patricia Collins - Marty Wojeck
- Ted Follows - Bateman
- Berkeley Harris - Richie Darden
- Berkeley Harris - Mikel Hawley
- Dana Andrews - Douglas Vinson
- Stuart Margolin - Jose
- John Marley - Gandez
- Arthur Godfrey - Sheriff Tinsley
- Diane Baker - Helen
- Don Knotts - Curly Kid
- Jack Benny - Self
- Percy Helton - Old Man
- Mary-Robin Redd - Pauline
- Jack Lambert - Sid Swine
- Herb Edelman - Seth Swine
- Robert Wagner - Harry Brophy
- Magda Harout - Chauffeur
- Naomi Stevens - Maria Pia
- Michael Rennie - Edward Parker Greene
- Donald May - Det. Jim Lassiter
- Tom Simcox - Lieutenant Walter Matthew
- Ben Gazzara - Sidney
- Frances Robinson - Boy's Mother
- Ellen Corby - Miss Purdy
- Ellen Corby - Charlotte
- Rhonda Fleming - Purity
- Bruce Cabot - Sheriff
- Shelley Winters - Jenny Dworak
- Lucille Ball - Self
- Leslie Nielsen - John Joslin
- Lloyd Bochner - Cmdr. Brand
- Rod Cameron - Tiny
- Sally Kellerman - Jerrie
- Richard Deacon - Self
- Madge Blake - Amy Zwiling
- Lyle Talbot - Gibralter
- Michael Sarrazin - Pvt. Tompkins
- Eve McVeagh - The Texan's Wife
- Eve McVeagh - Mrs. Sharpe
- Cyril Delevanti - McPherson
- Cyril Delevanti - Bishop Andrews
- Cyril Delevanti - Toulouse
- Cyril Delevanti - Mario
- Darren McGavin - Franklin Carson
- Glenn Corbett - Dave Gammon
- Dabney Coleman - Sergeant Harry King
- Dabney Coleman - Stanley Rivkin
- Ed Begley - Dr. Hayes
- Barbara Barrie - Laurel Catlan
- George Maharis - Michael Kolinos
- George Maharis - Miles Catlan
- Robert Pine - Lt. Brown
- Robert Pine - New Flier
- Michael Tolan - Lt. Murrow
- Maudie Prickett - Secretary
- Robert Clary - Marcel Pleusteau
- Ann B. Davis - Matha
- Sheila James Kuehl - Penelope
- Barry Nelson - Don Emerson
- Jack Kelly - Det. Ray Baker
- Jack Kelly - Al Packer
- Jack Kelly - Fred Piper
- Jack Kelly - Frederick Piper
- Joseph Campanella - Frank Mancini
- Jack Klugman - Markos
- Frank Overton - Gene Farrell
- Ed McMahon - Self
- Robert Culp - Peter Furgatch
- Carol Lawrence - Nan Barclay
- Carol Lawrence - Carol
- Steven Hill - Ruben Fare
- Efrem Zimbalist Jr. - John Ferris
- Malachi Throne - Phil Campbell
- Diane McBain - Show Girl
- Diane McBain - Self
- Vera Miles - Beth
- Herschel Bernardi - McCarthy
- Frank Albertson - Morgan
- Doris Singleton - Mrs. Bryant
- Nicholas Colasanto - Bernheim
- Nicholas Colasanto - P.J. Bascomb
- Nicholas Colasanto - Charlie Atkins
- Dan Frazer - Detective
- Robert Cummings - Harvey Hines
- Leo Gordon - Jolly Boy
- Leo Gordon - Biggie
- Sue Ane Langdon - Millie Bossack
- Joe Devlin - Zakaris
- Werner Klemperer - Colonel Wertha
- James Franciscus - Larry Martin
- Albert Carrier - Racine
- Horst Ebersberg - Lieutenant
- Jill St. John - Janie Douglas
- Jill St. John - Bunky
- Seymour Cassel - Police Sgt.
- Seymour Cassel - Somebody
- Lynn Loring - Joanna
- Donnelly Rhodes - Matt Braid
- Donnelly Rhodes - Jim Pitts
- Donnelly Rhodes - Mark
- Tony Bill - Tony Pitts
- Charles Seel - Father Prior
- Telly Savalas - Mueller
- Brooke Bundy - Stacey Carter
- Brooke Bundy - Fleming Holloway
- Rossano Brazzi - Luder
- Antoinette Bower - Maureen Hollings
- Michael St. Clair - George
- Marian McCargo - Eleanor Farrell
- Marian McCargo - Secretary
- Marian McCargo - Martha Holloway
- Suzanne Pleshette - Adrian Harris
- Suzanne Pleshette - Anita King
- Matt Clark - Paco Perez
- Jeff Corey - Reverend Mr. Mansard
- John Forsythe - Charlie King
- Carol Lynley - Irene Ayers
- Carol Lynley - Miranda Woodland
- Paul Reed - Mr. Prentice
- Susan Silo - Nancy Prentice
- Roy Roberts - Philip Murdock
- Margaret Mason - Dimples Lefembre
- John Considine - Ed Patterson
- John Considine - Richard Coburn
- Dick Sargent - Dick O'Hara
- Donald O'Connor - Benjamin Boggs
- Joan Blondell - Mrs. Melvin Freebie
- Ernest Borgnine - Melvin Freebie
- Paul Lynde - Judge
- Martin Milner - Stanley 'Stan' Patrick
- Martin Milner - Lt. Eric Kurtz
- Martin Milner - Stranger
- Hurd Hatfield - Tsezar
- John Fiedler - Aleshka
- George Kennedy - Der
- Leon Belasco - Thin Russian
- Leon Belasco - Rozzi
- Jean Hale - Princess Fawzie
- Jean Hale - Lise
- Jean Hale - Kathy Simmons
- Jack Ging - McAllister
- Warren Oates - Joe Grover
- Joanna Barnes - Connie
- Bob Newhart - Charles Fenton
- Patrick O'Neal - Senator Randolph
- Patrick O'Neal - Father Thaddeus
- Dorothy Provine - Julie
- Cliff Norton - Cab Fleet Owner
- Mickey Rooney - Lefty Duncan
- Harold J. Stone - Ernie Santee
- Harold J. Stone - Enrico
- Harold J. Stone - Borginin
- Harold J. Stone - Turin
- Peter Mamakos - Ganoulian
- Peter Mamakos - 1st Guard
- Victor Buono - Grebb
- Gary Owen - 2nd Reporter
- Woodrow Parfrey - DeCarlo
- Woodrow Parfrey - Kessler
- John Saxon - Mario Silvetti
- Madlyn Rhue - Lillian
- Diane Ladd - Cissy
- Virginia Vincent - Miss Clutha
- Emily Banks - Julie Thayer
- Emily Banks - Sister Monica
- Marvin Kaplan - Alvin
- Jack Lord - Harry Marcus
- Juliet Mills - Princess
- Juliet Mills - Mary Lewis
- Julie Sommars - Maggie Lake
- Joseph Mell - Waiter
- Joseph Mell - Bernie
- Joseph Mell - Proprietor
- Joseph Mell - Joey Rome
- Lauren Bacall - Amanda / Barbara
- Fay Wray - Mrs. White
- Tom Poston - Janitor / Lieutenant Courtney
- Lee Meriwether - Piper's Secretary
- Hugh O'Brian - Stanwood
- Jean Simmons - Ruth Bannister
- L.Q. Jones - Ernie Packer
- Lillian Bronson - Widow
- David Wayne - George Holloway
- Robert Young - Nick Holloway
- Bruce Gordon - Hartford
- Eric Braeden - Kurt Krug
- Eric Braeden - Manfred Scharff
- William O'Connell - Hugo
- Polly Bergen - Jennifer Randolph
- Lee Marvin - Nick Karajanian
- Peter Adams - Grant Morris
- Victor Brandt - Lou Brady
- John Baer - Billy
- Richard Bakalyan - Charlie
- Martin Balsam - Dave Breslaw
- Rita Lynn - Phyllis
- George Voskovec - Dr. Bensinger
- Roddy McDowall - Arthur Biddle
- Pat Crowley - Carol Sinclair
- James Farentino - Dr. Michael Simpson
- Anne Seymour - Sister Superior
- Melinda O. Fee - Nurse
- Lola Albright - Vickie Tate
- Lola Albright - Edith Woodland
- Ray Montgomery - Bert Wilson
- Paul Hartman - Luther
- Henry Beckman - Lt. Shaeffer
- Robert Sorrells - Garth
- Richard Bull - Frank Lacy
- George Hamilton - Victor Thornton
- Margaret O'Brien - Anne Lipscott
- Jerry Douglas - Lieutenant
- Dick Wilson - Man in the Bus Station
- Buddy Lewis - Cab Driver
- Fletcher Fist - Technician
- Raymond Mayo - Waiter
- Robert Fuller - Capt. William Judd Fetterman
- Phyllis Avery - Margaret Carrington
- Chuck Hicks - 2nd Sergeant
- Jeanette Nolan - Mrs. Gardner
- John Banner - General Zimring
- Peter Falk - Bara
- Peter Falk - Mike Galway
- Peter Falk - Bert Graumann
- Norman Fell - Eddie Carr
- Charles Lane - Charles Eckhardt
- Herb Vigran - George
- Stuart Whitman - Billy Cole
- Robert Emhardt - Thomas
- Rex Holman - McBane
- William Challee - The Clerk
- S. Lee Pogostin
- Arnold Perl
- David Rayfiel
- Roy Huggins
- Richard Berg
- Jack Laird
- Bob Hope
Naomi Stevens interpreta a Maria Pia en la serie.
Peter Falk interpreta a Bara en la serie.
Percy Helton interpreta a Old Man en la serie.
Marc Lawrence hace el papel de Orente.
John Marley interpreta a Gandez en la serie.
Ben Gazzara interpreta a Sidney en la serie.
Nehemiah Persoff interpreta a Alverian en la serie.
David Carradine hace el papel de Fitzhugh.
George Peppard hace el papel de Buddy Wren.
Mickey Rooney hace el papel de Lefty Duncan.
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