- Jodie Lynne McClintock - Dr. Paul
- Tama Filianga - Pyramid Thug
- Joe Holt - Det. Green
- Meredith Forlenza - Det. Brown
- Brian Dykstra - Det. White
- Jonathan Tindle - Cat-Man-Dude
- Adam Harrington - 1960s News Anchor
- Arthur Gerunda - Fishing Boat Captain
- Michelle Buteau - Beck
- Richie Moriarty - Mr. Everest
- Richie Moriarty - Arthur's Dad
- Michael McFadden - Thug #3
- Rich Pecci - Police Officer #2
- Eliazar Jimenez - Kid #2
- Kyle Catlett - Young Arthur
- Joanna Adler - Dr. Creek
- Malachi Weir - Thug #2
- Christian Navarro - Sidekick
- Whoopi Goldberg - Whoopi Goldberg
- Keet Davis - Thug #4 (uncredited)
- Keet Davis - Thug #4
- Andrew Dolan - Officer Dietz
- Henry Yuk - Shaman
- Berto Colon - Thug #1
- Siraj Huda - Cab Driver
- Brett Berg - Thug (uncredited)
- Roger Brenner - FDNY / EMT (uncredited)
- Marko Caka - Parent (uncredited)
- John Cenatiempo - Thug #3 (uncredited)
- Michael Cerveris - Ramses IV
- Ken Marks - Manager
- Ken Marks - Supervisor
- Mimi Gianopulos - Nikki
- Ava Lee Scott - Young Woman
- Helen Coxe - Photographer
- Helen Coxe - Photographer (uncredited)
- Eric Whitten - Drum Teacher
- Lora Lee Gayer - Rochelle
- Sulekha Naidu - Young Woman
- Dave Hill - Man
- Carla Brandberg - Matronly Woman
- Jacqueline Antaramian - Sonja
- Thomas Kopache - Nabokov
- Geoffrey Cantor - Agent Adams
- Michael Quinlan - CEO
- Dan Castiglione - Bakkup
- Bryan Greenberg - Derek
- Tyler Bunch - Stosh
- Paul Moon - Khufu
- Chris Cenatiempo - Lint Goon #6
- Anderson Matthews - TV Show Host
- Anderson Matthews - Graham Dyckman
- Juliet Adair Pritner - General Julie McGinnis
- John Pirkis - Dr. Karamazov
- Ryan Woodle - V-L-M
- Teodorina Bello - Ouma
- Townsend Coleman - Midnight (voice)
- Dawn McGee - Hannity
- Marmee Regine Cosico - Running Pedestrian (uncredited)
- Abby Awe - Bank Teller
- Matt Gehring - Larry
- Lily Brooks O'Briant - Young Dot
- Shadoe Stevens - Narrator (voice)
- Alexio Barboza - A.E.G.I.S. Bagpiper (uncredited)
- David H. Holmes - Shifty Man
- Christian Barber - Doorman
- Anthony Alessandro - Romeo
- DJ Renegade - Cameraman (uncredited)
- Erik Heger - Michael King
- Andrew Chappelle - Raphael
- Emily Tung - China Cabinet
- Jayne Houdyshell - Black Market Bob
- Grant Harrison - Ted
- Sathya Sridharan - Trooper Hooper
- Happy Anderson - Donny
- Hunter Emery - Danny
- Brian Faherty - Denny
- Lucas Dixon - Dougie
- Nick Westrate - Garrett Sinclair
- Tom O'Keefe - E Morgan Pearl
- Clara Wong - Veranda / Miranda
- Alan Tudyk - Dangerboat (voice)
- François Chau - Walter
- Patricia Kalember - Joan
- Joshua Schubart - Frank
- Jade Elysan - News Reporter
- Jade Elysan - Channel 8 Reporter
- Marc Kudisch - Ty Rathbone
- John Hodgman - Hobbes
- Julian Cihi - Edgelord
- Steven Ogg - Flexon
- Liz Vassey - Lobstercules (voice)
- Clé Bennett - Sage
- Devin Ratray - Tinfoil Kevin
- Niko Nedyalkov - Lobstercules (uncredited)
- Suzanne Waters - Lobster Baby (voice)
- Ben Edlund
- Wally Pfister
- Barry Sonnenfeld
- Nicolas Bradley
- Felicia Fasano
- Jenny Klein
- Chris Bacon
Whoopi Goldberg interpreta a Whoopi Goldberg en la serie.
Peter Serafinowicz interpreta a The Tick en la serie.
Griffin Newman interpreta a Arthur Everest en la serie.
Valorie Curry interpreta a Dot Everest en la serie.
Brendan Hines interpreta a Superian en la serie.
Yara Martinez interpreta a Miss Lint en la serie.
Scott Speiser interpreta a Overkill en la serie.
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