- Daria Johns - Savannah
- Mike Dolphy - Donovan
- Page Kennedy - Duck
- Leonard Earl Howze - Davis
- Michel Estime - Tony
- Lovensky Jean-Baptiste - Jake
- Hayley Marie Norman - Kyla
- Brandon Mitchell - Randy Giles
- Colin Koth - Waiter
- Dayna Dooley - Sheila Morrison
- Jahdai Pickett - Trey
- Ronnie Alvarez - Dr. Alvarez
- Jeremy Denzlinger - Cop #1
- Jessica Morris - Amy Holmes
- Casey J. Adler - Ernest Smalls
- Maxwell Glick - Question Master
- Chip Chinery - Malcolm
- Dewayne Perkins - Hector
- Adam Lazarre-White - Captain Cam Wilson
- Diane Delano - Jan Dewitt
- Aina Dumlao - Ms. Lee
- Cristela Alonzo - Anna Garcia
- Jeremy Gimenez - Nathan Brash
- Anais Lee - Steph Greene
- Michelle N. Carter - Bobbie
- Nikea Gamby-Turner - Nan
- Christal Marie Deloney - Bartender
- Michael Cory Davis - Dr. Keon Bevans
- Frank Gallegos - Craig
- Debbie Fan - Ms. Taniguchi
- M.J. George - Martin Owens
- Sharifa Oliver - Monique
- Ayaamii Sledge - Sydney
- April Hale - Darlene
- Chris Wu - Noah Yang
- Robert Buscemi - Inspector
- Lamont Thompson - Frank
- Chris Williams - Larry
- Rosalind Russell - Shanice
- Kym Whitley - Althea Turner
- Maya Nalli - Davia
- Ronin Lee - Otis
- Andrew Neaves - Clarke
- Danny Fehsenfeld - Police Officer
- Marsha Warfield - Glodine
- Andrew Hansen - Customer
- Karen Armstrong - Pastor
- Keith Walker - Server
- Shaw Jones - Barry
- Dani Woodson - Luanne
- Derek Yates - Greg
- Mike Peebler - Police Officer
- Ausby Larkin - Police Officer
- L.J. Batinas - Inmate
- Branden Wellington - Inmate
- Layla Crawford - Chayla
- Nomsa Mlambo - Jackie
- Mateo Pollock - Jamar
- Alonzo B. Slater - Jon Terri
- Rahul Rai - Customer
- Gary 'G. Thang' Johnson - Customer
- Ben Zelevansky - Security Guard
- Chad Doreck - Josh
- Melinda Chilton - Millicent
- Scott Cooper Ryan - Greg
- Samantha Cutaran - Waitress
- Larvell Hood - Kev
- Katie Hall - Customer
- Courtney Nichole - Carlotta
- Sheila E. - Dreux
- Leonard Roberts - Mitch
- Kim Yarbrough - Dr. Moses
- Ethan Corn - Brett
- Dino Shorte - Satie
- Dawan Owens - Dr. Malcolm Webber
- Bobby McGee - Mr. Lewis
- Renda Pettis - Gladys
- Tasia Sherel - Nurse Williams
- Jessica Buda - Nancy
- Reatha Grey - Mrs. Greene
- Innocent Ekakitie - MLK
- Brett Bartlett - Announcer
- Brett Bartlett - Steve
- Kunal Chopra - Waiter
- Faizon Love - Terry
- Jenifer Lewis - Dr. Pearl Edmunds
- Shondalia White - Sharice
- Sean Alexander James - Security Guard
- Matthew Gilmore - Guy
- Brandon Brown - Barfly
- Dutch Johnson - Silver Fox
- Samantha Turret - Peg
- Taya Amerson - Vice Principal (voice)
- Brick Jackson - Coach Hicks
- Paul Culos - Andre
- Meredith Richardson - Brianna
- Jon Ryckman - Marquis
- Greg Roman - Gary
- Zachary Fineman - Nicholas
- Zeke Alton - Police Officer
- Emilio Rivera - Barkavious
- Paul-Mikél Williams - Tristan
- Yvans Jourdain - Mr. Baptiste
- Rosanny Zayas - Sofia
- Michael Gambino - Charles
- Erin Coker - Laura
- Dondré Whitfield - James
- Tabitha Brown - Miss Wilson
- Tony Espinosa - Young Bennie
- Tiberius Byrd - Young Malcolm
- Tammy Townsend - Angela
- Noelle Mahasin - Renee
- Tasha Ames - Instructor
- Kristopher Charles - Handsome Man
- Carson Zone - Waiter
- Isaiah Frizzelle - Man
- Ashley Monique Clark - Stephanie
- Ken Whittingham
- Phill Lewis
- Niles Kirchner
- Regina Y. Hicks
- Page Hurwitz
- Wanda Sykes
- Mike Epps
Wanda Sykes interpreta a Lucretia en la serie.
Mike Epps interpreta a Bennie Upshaw en la serie.
Kim Fields interpreta a Regina en la serie.
Khali Daniya-Renee Spraggins interpreta a Aaliyah en la serie.
Journey Christine hace el papel de Maya.
Jermelle Simon interpreta a Bernard en la serie.
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