- Lauren Graham - Gaby
- Desi Lydic - Kim
- Dave Foley - Roy
- Andrea Bogart - Olivia
- Penny Marshall - Patty
- Pam Dawber - Arnette
- Don Most - Fred
- Marion Ross - Edna
- Anson Williams - Clayton
- Cindy Williams - Vivian
- Ron Howard - Stanley
- Carol Mack - Regina
- Carla Renata - Raylene
- Ivan Mallon - Young Joshua
- August Maturo - Simon
- Brianne Howey - Allyson
- Ali Ghandour - DJ
- Leena Huff - Lizzie
- Greg Romero Wilson - Manager
- Leslie Bibb - Casey
- Jeremy Rabb - Jim
- Charles Carpenter - Link
- Dwight Howard - Dwight Howard
- Eileen O'Connell - Cindy
- Andy Earnest Spencer - Alan
- Ben Cain - Will
- Kurt Long - Dart Guy
- Lise Simms - Deena
- Paolo Andino - Chad
- Nikki Tuazon - Waitress
- Erinn Hayes - Sharon McManus
- Emily Kosloski - Marilyn
- Rich Eisen - Rich Eisen
- Kenny Smith - Kenny Smith
- Olivia Sandoval - Stage Manager
- Blaine Swen - Carl
- Michael Dunn - Kevin
- Angelique Cabral - Amy
- Desiree Hall - Jessica
- Chris Webber - Chris Webber
- Christine Woods - Ashley
- Robb Derringer - Bill
- Will McLaughlin - Handyman
- 'Weird Al' Yankovic - Steve
- Regis Philbin - Walter
- Melissa Haro - Ingrid
- Tiffany Panhilason - Woman
- Rene Moran - Young Man
- Bianca Lopez - Young Woman
- Jay Brian Winnick - Passenger
- Casey Washington - Guy
- Donna Pieroni - Female Passenger
- Brett Gelman - Stuart
- Alex Ball - Waiter
- Alex Ball - Bar Guy
- Mircea Monroe - Brooke
- Rose Abdoo - Helen
- Geoff Stults - Murph
- Judy Kain - Maureen
- Ryan Quinn Smith - Kid
- Don Lake - Kent
- Caleb Brown - Evan
- Lenny Venito - Frank
- Lisa Ann Walter - Linda
- Mary Jo Catlett - Elderly Woman
- Teri Hatcher - Charlotte
- Amir Abdullah - Rapper
- Garry Marshall - Walter Madison
- Steven Boldis - Mr. Met
- Conor Duffy - Mets Official
- Simon Templeman - Nigel
- Sheryl Underwood - Diane
- Joanna Cassidy - Judy
- Brad Lee Wind - Cal
- Martin Yu - Shopkeeper
- Jim Rash - Joshua
- David Pressman - Norman
- Bryant Tardy - Andre
- Dimiter D. Marinov - Sasha
- Micah Nelson - Young Felix
- Jill Basey - Neighbor
- Jerry Lambert - Wayne
- Vernee Watson-Johnson - Frannie
- Don Stark - Mr. Blaustein
- Krizia Bajos - Peg
- Robert Ben Garant - Officer
- Kent Avenido - Security Guard
- Peter Ngor - Teen
- Greice Santo - Gia
- Cynthia Kaye McWilliams - Alexis
- Shawn Stockman - Shawn Stockman
- Wanya Morris - Wanya Morris
- Nathan Morris - Nathan Morris
- Londale Theus Jr. - Driver
- Fred Willard - Fred Langford
- Luis Victor Jimenez - Bartender
- Jim Shipley - Guy
- Vivian Lamolli - Woman
- Izabella Alvarez - Birdie
- Ethan Michael Mora - Frank
- Jayden Maddux - Kid #1
- Chris Bosh - Chris Bosh
- Lesley Nicol - Marge
- Jackie Moore - Amber
- Christopher Gehrman - Sherlock
- Lauren Baldwin - Donna
- Flora Rubenhold - Queen Elizabeth
- O'Neill Monahan - Noah
- Rebecca Klingler - Madeline
- Dio Johnson - Instructor
- Damian Gomez - Waiter
- Caroline Aaron - Christina
- Derek Basco - Delivery Guy
- Jessica Walter - Meredith Unger
- Sheila Carrasco - Lilias
- Nardeep Khurmi - Lance
- Busy Philipps - Natasha
- Saba Homayoon - Eve
- Carol Herman - Muriel
- Christina Ulloa - Michelle
- Luc Robitaille - Luc Robitaille
- Duane Martin - Michael
- Ausby Larkin - Luke
- Judilin Bosita - Production Assistant
- Pamela Roberts - Parishioner
- Brandon Sutton - Troy
- Parvesh Cheena - Neil Armstrong
- Artie O'Daly - Terrance
- Andy Cadiff
- Jeff Greenstein
- Mark Cendrowski
- Phill Lewis
- Ryan Raddatz
- Bob Daily
- Tad Quill
- Matthew Perry
- Danny Jacobson
- Stephanie Furman Darrow
Matthew Perry interpreta a Oscar Madison en la serie.
Joanna Cassidy hace el papel de Judy.
Caroline Aaron interpreta a Christina en la serie.
Lisa Ann Walter interpreta a Linda en la serie.
Garry Marshall interpreta a Walter Madison en la serie.
Thomas Lennon interpreta a Felix Unger en la serie.
Lindsay Sloane hace el papel de Emily.
Yvette Nicole Brown interpreta a Dani en la serie.
Wendell Pierce interpreta a Teddy en la serie.
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