- Keye Luke - Leong Chung Hua
- Ken Curtis - Orville Gant
- Wilford Brimley - Sheriff Daniels
- Robert Ito - Chuk
- Keith McDermott - Everett
- Horst Buchholz - Sergei
- Soon-Tek Oh - Kee
- Fernando Lamas - Fierro
- David Yanez - Manuel
- Richard Kelton - Clay Hollingsworth
- Victor Sen Yung - Hospital Attendant
- George Caldwell - Andy Hooper
- Kip Niven - Lt. Ayeless
- Denver Pyle - Sgt. Tripp
- Richard Moll - Mose
- Bill Fletcher - The Boatswain
- Rosalind Chao - Li Sin
- Virginia Wing - Kee's Mother
- Bill Zuckert - Ship's Doctor
- Joaquín Martínez - Amando Perez
- John Doucette - Sheriff Boland
- Beverly Garland - Hanna
- Richard Evans - Druey
- Richard Davalos - Captain Olini
- Rex Holman - Luther
- John Dehner - Bishop Benjamin
- William Conrad - Narrator (voice) (uncredited)
- Anthony Zerbe - Martin Grey
- Don Murray - Anderson
- Jack Elam - Cully Madigan
- Paul Fix - Portagee
- G.W. Bailey - Ivie
- Ted Jordan - Willie
- Ted Jordan - Charlie
- Bridget Hanley - Sheila
- Biff McGuire - Ed Walters
- Michael Conrad - Marshal Russell
- Michael Conrad - Marshall Russell
- Jean Allison - Mrs. Stillman
- Read Morgan - Lem
- Read Morgan - Morton
- Alvy Moore - Swenson
- John Pickard - Col. Caine
- John Pickard - Jim Turner
- Warren Vanders - Brant
- Belinda Montgomery - Florrie
- L.Q. Jones - Batlin
- David Sheiner - Wilson
- George DiCenzo - Tomaz
- Lloyd Bridges - Orville Gant
- Tim Matheson - Curt Grayson
- Vera Miles - Beth
- William Shatner - Captain Harrison
- Peggy McCay - Maggie Taylor
- Tom Simcox - Marshal Logan
- Martha Smith - Ellen Taylor
- Mills Watson - Felix
- Mills Watson - Hutch
- Lucille Benson - Miss Walker
- Lucille Benson - Miss Agnes
- Harris Yulin - Deek Peasley
- Robert J. Wilke - Appleton
- Wayne Heffley - Storekeeper (uncredited)
- Eric Braeden - Francis Britten
- Robert Donner - Mr. Evans
- Dub Taylor - Moss
George DiCenzo interpreta a Tomaz en la serie.
Eva Marie Saint interpreta a Kate Macahan en la serie.
Richard Davalos interpreta a Captain Olini en la serie.
Anthony Zerbe interpreta a Martin Grey en la serie.
Ann Doran interpreta a Grandma en la serie.
James Arness interpreta a Zeb Macahan en la serie.
Fionnula Flanagan interpreta a Molly Culhane en la serie.
Bruce Boxleitner hace el papel de Luke Macahan.
Kathryn Holcomb interpreta a Laura Macahan en la serie.
William Kirby Cullen interpreta a Josh Macahan en la serie.
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