- Kika Mirylees - Zola Zbzewski
- John Bluthal - Jack Holiday
- Charles Kay - Elliot Strange
- Rae Baker - Yasmin
- Marcus Gilbert - Jason Tippet
- Deborah Grant - Antonia Stangerson
- Peter Copley - Eric
- Maxine Peake - Marion Cretiss
- Lee Ingleby - Derek Spratley
- Diana Weston - Delia Masson
- Michael Brandon - Captain Frank Candy
- Dinah Sheridan - Kathleen Gilmore
- Lysette Anthony - Mimi Tranter
- Trevor Peacock - Henry Houseman
- Jeffrey Segal - Marco Bergman
- Celia Imrie - Thelma Bailey
- Nigel Planer - Shelford
- Simon Day - Jordan Strange
- Ralph Brown - Roy Pilgrim
- Alistair McGowan - Trevor
- Nicola Walker - WPC Fay Radnor
- Pippa Haywood - Lorna Claithorne
- Bob Monkhouse - Sylvester Le Fley
- Andrew Tiernan - Lenny Spearfish
- Harry Peacock - Floyd Goodman
- Margery Mason - Audrey Panguitch
- Charlie Brooks - Trudi
- Nicholas Ball - Vincent Rees
- Gina Bellman - Samantha
- Sophie Thompson - Dorothy Moon
- Maureen Lipman - Louise Bergman
- Bamber Gascoigne - Presenter
- Michael Mellinger - Mr Schmitz
- Bernard Kay - Oliver
- Annette Crosbie - Ingrid Strange
- Saskia Mulder - Francesca Boutron
- Brian Murphy - Ken Speed
- Dermot Crowley - Norman Stangerson
- Gavan O'Herlihy - Hal Drucker
- Griff Rhys Jones - Jeremy Sangster
- Hattie Hayridge - Lizzie Gillespie
- James Gaddas - Craig Downey
- Benjamin Whitrow - Rupert Clifford-Wright
- Jim Bowen - Duggie Dawson
- Michael Grade - Michael Grade (uncredited)
- Nicholas Jones - Claude Bergman
- Catherine Cusack - Ashley Farr
- Colin McFarlane - Inspector Fell
- Colin Stinton - Scott Reisner
- Selina Cadell - D.I. Masterson
- Heather-Jay Jones - Tracy Cook
- Doug Fisher - Stephen Grismal
- Lorelei King - Justine Bailey
- Jonathan Ross - Jonathan Ross
- Peter Blake - Otto Danzigger
- Hetty Baynes - Jacqui
- Victoria Shalet - Carrie Bergman
- Petra Letang - Jessica
- Bob Mercer - Callum
- Geoffrey Beevers - Neville Spivey
- Peter Davison - Stephen Claithorne
- Christine Kavanagh - Lady Theresa Cutler
- Paul Blackthorne - Gino
- Tom Goodman-Hill - Jeff
- Tamsin Greig - Pam
- Bill Bailey - Kennie Starkiss
- Steve Speirs - Herbie Bryant
- Maureen O'Brien - Kirsten Holiday
- Jane Hazlegrove - Katrina Toplis
- Debbie Arnold - Sadie Bechtenstein
- Rebecca Front - Heidi
- Emma Kennedy - Christine
- Adrian Edmondson - Brendan Baxter
- Sheila Gish - Serena Shale
- John Bennett - Frank Geiger
- Terrence Hardiman - Andre Masson
- William Vanderpuye - DCI Jack Horner
- Rob Jarvis - Tex
- Rob Jarvis - Wino
- Jack Dee - Dudley Houseman
- Jill Baker - Donna Henry
- Colin Baker - Hedley Shale
- Colin Hill - MacDonald / Security Officer
- Meg Davies - Emma Lazarus
- Sara Markland - Cathy Strange
- Barnaby Kay - D.C. Spelling
- Geraldine Alexander - Francine Faraday
- Vince Leigh - Sergeant
- Caroline Loncq - Sheena
- Del Henney - Inspector Gibbins
- Mel Cobb - Jacob Flowers
- Christine Moore - Polly Flowers
- Michael Sarne - Martin Crow
- David Riley - Newsreader
- Jonathan Cake - Hippy protestor (uncredited)
- Valerie Colgan - Martha
- Evie Garratt - Scooter Lady
- John Hudson - Roy Gregson
- Jemma Churchill - Second Therapist
- Lucy Allen - Masseuse (uncredited)
- Stanley Townsend - Det. Inspector Barrison
- Annabel Mullion - Felicity Vale
- Alistair Petrie - Duncan Proctor
- Stephen Billington - Neville Bruce
- Calum MacPherson - Buster
- Andrew Barrow - Ben
- Akemi Otani - Kiko
- Jennifer Piercey - Kitty
- Jennifer Piercey - Kitty Burgess
- Amanda Holden - Petra
- Clarke Peters - Hewie Harper
- Georgie Glen - Mrs Kilby
- Alan Corser - Old Man
- Peter Hughes - Coroner
- Edward Halsted - Mel Porthropp
- Edward Halsted - Mel Palthropp
- Adjoa Andoh - Anthea Spacey
- Anthony Stewart Head - Adam Klaus
- Brett Fancy - Troy
- Nick Hamilton - Detective Inspector
- Terry Bird - Security Officer
- Sandy Johnson - Paramedic (uncredited)
- Sandy Johnson - Man in loo (uncredited)
- John Shrapnel - Prof. Lance Graumann
- Sonya Saul - T.V. Interviewer
- Jane Booker - Phillipa Farell
- Calvin Williams - Sergeant Kribotnik
- Sean Cronin - Party Guest
- Mark Aiken - Robin Priest
- Sara Stephens - Shirley Priest
- Nicholas Amer - Bill
- Frances Low - Daphne
- Ben Craze - Colin
- Nina Sosanya - Karen Blaine
- Cavan Clerkin - Sidney Australia
- Denise Francis - Researcher
- Leonard Kavanagh - Judge Forrest Sweetland
- Georgine Anderson - Gwynneth Sweetland
- Barbara Horne - Dr. Laura Climpson
- David McKail - Clifford Jennings
- Hilary Sesta - Bag Lady
- Bob Friend - Newsreader (uncredited)
- Mark Hampton - Triad Gangster (uncredited)
- Zoë Hart - Rebecca Knape
- Graham Bryan - Lewis French
- Diane Witter - Bernice
- Steve Nallon - Rupert
- Mark Caven - Tom Terici
- Christopher Adamson - The Stalker
- Martina Laird - Bridget
- Frankie Park - Tessa
- Jimmi Harkishin - Gary Lobo
- Keith Morris - Waiter
- John Bird - Horace Greeley
- John Bird - D.I. Nathan Gallo
- Caroline Carver - Sally Ellen Oakley
- Angela Curran - Mavis
- Robin Kermode - Mr. Jellcoe
- Michael Cochrane - Owen Glendower
- Alex Lowe - Alan Tunstall
- Brenda Cowling - Mrs. Thrimpson
- Alice Patten - Gillian Bailey / Dawn
- Joanna Brookes - Autograph Woman
- David Morris - Leo Laughton-Jones
- Sidney Cole - Witchdoctor (uncredited)
- Chris Mansfield - Police Sergeant (uncredited)
- Frank Boyce - Waterboard Worker
- Andrew Buckley - Marty
- Myra McFadyen - Hattie Baron
- Robert Purdy - Officer
- Jordan Long - Roy
- Stephanie Carey - Nurse
- Terence Hillyer - Inspector Ted Parnevik
- Tina Martin - Velda
- Anna Wilson-Jones - Sergeant Heather Davey
- Toby Walton - Reporter
- Andrew Clover - Gary Basco
- Anna Francolini - Coral
- Veronica Leer - Moira Jane Rowe
- Gary Cady - Justin Mallory
- Jonathan Kydd - Mickey Daniels
- Nicola Hughes - Phylicia
- Jason Tompkins - Josef
- Eve Polycarpou - Andonea
- John MacDonnell - Cutting Room Editor (uncredited)
- Allistair Wyndham - Man in street (uncredited)
- Hilary Lyon - Cleo Paterson
- Ralf Beck - Rudi
- Philip McGough - Sam Brickman
- Ron Berglas - David Churchin
- Rebecca Johnson - Victoria
- Nick Maloney - Stage Doorman
- Leo Dolan - Delivery Man
- Shona Morris - Shelford's Wife
- Robin Soans - Alan Rokesmith
- June Watson - Rachel Rokesmith
- Helena McCarthy - Mrs Rokesmith
- Andrew Powell - Police Officer at Shelter
- Emma Noble - Girl in Banana Commercial (uncredited)
- William Franklyn - Narrator of Banana Commercial (voice) (uncredited)
- Rebecca Charles - Joy
- Alan Thompson - Mr Winstanley
- Lloyd McGuire - D.S. Owen Davey
- Mem Ferda - Drunk
- Christine Ellerbeck - Supermarket Cashier
- Geoffrey McGivern - Barry Opper
- Shaun Chawdhary - News Reporter
- Tim Chipping - Martin
- Hugh Parker - Waiter
- Simon Thomas - Christophe Holtz
- Ali Bastian - Juno Pirelli
- Marianne Borgo - Zelda Niedlespascher
- Ross Armstrong - Angus
- Alice O'Connell - Rachel
- Raquel Cassidy - Sharon
- Rhydian Jones - Darryl
- Kieran Hodgson - Ridley
- Roy Sampson - Mr. Partridge
- Paula Wilcox - Hazel Prosser
- Marc Danbury - Burglar 1
- James Bachman - Rev Hugh Chater (uncredited)
- James Bachman - Rev Hugh Chater
- Tim Faraday - Crispin Gilpin
- Jarred Christmas - Warwick
- David Gant - Eric Ipswich
- Selina Griffiths - Alison Chater
- Adam Grayson - Young Eric Ipswich
- John Voce - Captain Ian Amery-Cooper
- Michael Troughton - Leonard Corbyn
- Nigel Genis - Funeral Guest (uncredited)
- Nigel Genis - Birdwatcher (uncredited)
- Richard Banks - Man at 1960s fair (uncredited)
- Elizabeth Conboy - Lindsey Isherwood
- Teddy Nicholas - Karl
- Uriel Emil Pollack - Ethan
- June Whitfield - Heidi Greeley / Laurel Greeley
- Josie Lawrence - Denise
- Melanie Gray - Daisy Shand
- Dar Dash - Kevin
- Mark Flitton - Dean
- Caroline Lee-Johnson - DI Karen Addams
- Paul Blackwell - Police Enforcer (uncredited)
- Alexander Pownall - Little Boy
- Haruka Kuroda - Presenter
- Takako Akashi - Wife
- Selva Rasalingam - Sharif
- Robert Atiko - Anwar
- James Barron - Mr. Cutler
- Takuya Matsumoto - Husband
- Scott Chisholm - Rhino
- Cliff Barry - Joe Wheeler
- Pete Thornton
- David Renwick
Steven Berkoff hace el papel de Herman Grole.
John Shrapnel interpreta a Prof. Lance Graumann en la serie.
Stephen Billington interpreta a Neville Bruce en la serie.
Ian McNeice hace el papel de Father Roderick Alberic.
Selina Cadell hace el papel de D.I. Masterson.
Alan Davies interpreta a Jonathan Creek en la serie.
Sarah Alexander interpreta a Polly Creek en la serie.
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