- Jerry Seinfeld - Self
- Ray J - Self
- St. Vincent - Self - Music Performance
- Jon Stewart - Self
- Gabriel Iglesias - Self
- Mae Martin - Self
- Warren G - Self - Music Performance
- Nate Bargatze - Self
- Patton Oswalt - Self
- Sarah Silverman - Self
- Tom Segura - Self
- Ronny Chieng - Self
- Rivers Cuomo - Self - Music Performance
- Patrick Wilson - Self - Music Performance
- Brian Bell - Self - Music Performance
- Scott Shriner - Self - Music Performance
- David Letterman - Self
- Bill Hader - Self
- Cedric the Entertainer - Self
- David Hidalgo - Self - Music Performance
- Louie Pérez - Self - Music Performance
- Cesar Rosas - Self - Music Performance
- Conrad Lozano - Self - Music Performance
- Steve Berlin - Self - Music Performance
- Hannah Gadsby - Self
- Flea - Self
- Beck - Self - Music Performance
- Will Ferrell - Lou Adler
- Tony Tucci - Self
- Stavros Halkias - Self
- Andy Samberg - Jimmy Goldstein
- Zoey Tur - Self
- Earthquake - Self
- Marcia Clark - Self
- James Austin Johnson - Bob Dylan
- Fred Armisen - Self
- Lee Ving - Self
- Mike Watt - Self
- Kid Congo Powers - Self
- Don Bolles - Self
- Exene Cervenka - Self
- Joe Baiza - Self
- George Hurley - Self
- Penelope Houston - Self
- Cassandra Peterson - Self
- Nick Kroll - Gil Faizon
- Jimmy Kimmel - Caller
- Luenell - Self
- Kevin Gage - Waingro
- Pete Davidson - Self
- Ben Mankiewicz - Self
- Brian Grazer - Self
- Karen Bass - Self
- Mike Birbiglia - Self
- Rajat Suresh - Political correspondent
- Nikki Glaser - Self
- Jeremy Levick - Reverse Borat
- John Carpenter - Self
- George Wallace - Self
- Fortune Feimster - Self
- Langston Kerman - Self
- John Foy
- Becca Kinskey
- Rosie Kaller
- Molly Lambert
- James Kim
- Jonna Roe
John Mulaney hace el papel de Self - Host.
Richard Kind interpreta a Self - Announcer en la serie.
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