- Steven Hinkle - Young John Quincy Adams
- Madeline Taylor - Young Nabby Adams
- John Dossett - Benjamin Rush
- Ebon Moss-Bachrach - John Quincy Adams
- Samuel Barnett - Thomas Adams
- Andrew Scott - Colonel William Smith
- Kevin Trainor - Charles Adams
- Mamie Gummer - Sally Smith Adams
- Boris McGiver - Robert Goddard
- John Bedford Lloyd - Richard Palmes
- Ritchie Coster - Captain Preston
- Guy Henry - Jonathan Sewall
- Justin Theroux - John Hancock
- Bill Buell - Justice Lynde
- Brennan Brown - Robert Treat Paine
- Ed Jewett - James Duane
- Del Pentecost - General Henry Knox
- Neal Huff - Captain John Tucker
- Jean-Hugues Anglade - Comte de Vergennes
- Tom Hollander - King George III
- Judith Magre - Madame Helvétius
- Cyril Descours - Edmund Charles Genet
- Alan Cox - William Maclay
- Hugh O'Gorman - Thomas Pinckney
- Jack Gwaltney - John Marshall
- John Keating - Timothy Pickering
- Jason Butler Harner - Oliver Wolcott, Jr.
- Zak Orth - James McHenry
- Lucas N. Hall - Bostonian Townsperson
- Lucas N. Hall - Continental Army Officer
- Tom Hooper
- Kirk Ellis
- David McCullough
- Tom Hanks
- David Coatsworth
- Steven Shareshian
- Kathleen Chopin
- Kirk Saduski
- Frank Doelger
Tom Hollander interpreta a King George III en la serie.
Del Pentecost interpreta a General Henry Knox en la serie.
Paul Giamatti interpreta a John Adams en la serie.
Laura Linney interpreta a Abigail Adams en la serie.
Stephen Dillane hace el papel de Thomas Jefferson.
Danny Huston interpreta a Samuel Adams en la serie.
David Morse hace el papel de George Washington.
Sarah Polley interpreta a Abigail Adams Smith en la serie.
Tom Wilkinson interpreta a Benjamin Franklin en la serie.
Steven Hinkle hace el papel de Young John Quincy Adams.
Capítulo disponible en las siguientes plataformas:
