- Nancy O'Dell - Nancy O'Dell
- Susan Dalian - Maureen
- Josh Randall - Roger
- Peter Stormare - Viktor
- Trev Broudy - Mark
- Amanda Swisten - Miss Santa Fe
- Dayna Devon - Reporter #2
- Jay Leno - Jay Leno
- Shanna Moakler - Mariska
- Brianna Brown - Elsa
- Deborah Theaker - Lorraine
- John Larroquette - Benjamin Lockwood
- Branscombe Richmond - Ray
- Coolio - Coolio
- Ellen DeGeneres - Ellen DeGeneres
- Kristin Richardson - Edie
- Kelly Preston - Donna
- Lawrence Mandley - Slate Guy
- Jayma Mays - Molly
- Reagan Dale Neis - Jane
- Bob Odenkirk - Brian Michael David Scott
- Danny Nucci - Ron
- Tom Lenk - Thomas
- Lanisha Cole - Miss Reno
- Portia Dawson - Tracy
- Beth Littleford - Carla
- Antonio Sabàto, Jr. - Kyle
- Christina Ricci - Mary Teresa
- Carmen Electra - Carmen Electra
- Jenna Dewan - Tanya
- Dan Cortese - Chuck
- Alan Thicke - Alan Thicke
- Matt Letscher - Eric
- Joyce Giraud - María
- Richard Ruccolo - Glen
- Lisa LoCicero - Celeste
- George Hamilton - George Hamilton
- Robert Costanzo - Joey Sr.
- Alyson Stoner - Kaley
- Geoff Stults - Jake
- Irene Olga López - Client
- John Ducey - Steve
- Patrick Kerr - Producer
- Rachel Blanchard - Joelle
- Mo Collins - Ms. Lafferty
- Colby Donaldson - Gunnar
- John Bliss - Grandpa
- Lombardo Boyar - Dave
- Andy Milder - Trent
- Ethan Erickson - Sam Baxter
- Mindy Sterling - Casting Director
- Camille Guaty - Debbie
- Lucy Liu - Lauren
- Jeff Bryan Davis - Martin
- Michael Trucco - Paul
- Julia Sweeney - Tracy
- Cindy Margolis - Cindy Margolis
- Lance Barber - Steve
- Wayne Wilderson - Director #2
- Julia Duffy - Kimberly
- Danneel Ackles - Katie
- Louie Anderson - Louie Anderson
- Terry Rhoads - Jerry
- Dave Foley - Dave Foley
- Candace Smith - Cute Girl
- Mädchen Amick - Sara
- Charlene Amoia - Diane
- Marshall Manesh - Lloyd
- Mitch Silpa - Tim
- Susan Leslie - Woman #1
- Tom Hughes - Actor #1
- Christopher T. Wood - Dave
- Jacqueline Lord - Vanessa
- Cindy Lu - Hotel Employee #1
- Sabin Rich - DJ
- James Lipton - James Lipton
- Stephnie Weir - Maureen
- Joey Honsa - Jackie
- John Antonini - Barry
- Tisha Terrasini Banker - Mary
- Simon Helberg - Seth
- Kristen Miller - Jenna
- Neil Flynn - Father O'Neill
- Adam Goldberg - Jimmy
- Kevin Farley - Man
- Kevin Farley - Drunk Santa
- Kevin Smith - Kevin Smith
- Bobb'e J. Thompson - Kenny
- Brad Schmidt - Guy #1
- Carlos Gómez - Director
- Betty White - Mrs. Bly
- Tim Bagley - Leonard
- Gina St. John - Susan Walters
- Alex Reznik - Boris
- Sharmila Devar - Renata
- Caroline Choi - Sonja
- Paula Cale - Abby
- Valerie Azlynn - Candace
- Nancy Linehan Charles - Gloria
- James Greene - Walter
- Linda Porter - Edith
- Rachel Quaintance - Chris
- Molly Bryant - Mary
- Gwen Van Dam - Grandma
- John Michael Higgins - Albert
- Andrea C. Robinson - Ivana
- Gregory Harrison - Dean
- Fiona Gubelmann - Anna
- Davis Mikaels - Jason
- Paull Walia - Travis
- Alex Ball - Todd
- Alex Ball - Director
- Alex Ball - Gary
- Dwain A. Perry - Dwight
- Dina Spybey-Waters - Judy
- Amy Landers - Denise
- Lisa Arturo - Charlene
- Tommy Perna - Criminal
- Tommy Perna - Sweaty Cop
- Tommy Perna - Courier
- Tommy Perna - Sal
- Jenna Gering - Heather
- Michelle Anne Johnson - Casting Director
- Loren Lester - Producer
- Josh Green - Steve
- Boni Yanagisawa - Make-Up Lady
- Gary Kraus - Stagehand
- David Mattey - Thug
- Manny M. Hernandez - Juan
- Carissa Kosta - Make-Up Lady
- Eric Edelstein - Special Effects Guy
- Lou George - Doctor
- Marilyn O'Connor - Letty
- Connor Chavarria - Tyler
- Joaquín Garrido - Officiant
- Sierra Edwards - Woman #2
- Jennifer Ann Burton - Waitress
- Melanie Paxson - Marci
- Catherine McCord - Woman
- Aalok Mehta - Rajeev
- Jim Bentley - Dodgers Executive
- Nancy Daly - Woman
- Ben Falcone - Howard
- Nat Faxon - Bodie
- Steve Schirripa - Pit Boss
- Thomas Fowler - Director
- Wayne Lopez - Cop
- Richard Whiten - Jack
- Burnadean Jones - Morgan
- Paul Kent - Professor Brightwiser
- Lawrence H. Toffler - Lance
- Arloa Reston - Elisa
- Bob Saget - Bob Saget
- Rich Levier - Dealer
- Carlos Sanchez - Employee
- Kim Harris - Slate Person
- Nathan Anderson - Reporter #1
- Donna Cooper - Reporter #3
- Gerald Downey - Mercedes Guy
- Melanie Abramoff - Little Girl
- Harley Zumbrum - Big Judoman
- Max Daniels - Little Judoman
- Holly Joy Gaines - Woman
- John Ciccolini - Violinist
- Don Perry - Pop-Pop
- Annie Wood - Trashy Woman
- Rick Fitts - Salesman
- Lizbeth Santos - Woman #1
- Carolyn Neff - Woman #2
- Michelle Bonilla - Saleswoman
- Terence Bernie Hines - Happy Man
- Gloria Garayua - Happy Woman
- Andrew Caple-Shaw - Guy #3
- Brian Gross - Guy #2
- David Sullivan - Guy #4
- Mario Revolori - Kid #1
- Kurt Doss - Kid #2
- Patricia Place - Old Woman
- Dylan Bruce - Waiter
- Brandon Stacy - Man in Bar
- Mieko Hillman - Woman #1
- Shaughn Buchholz - Delivery Man
- Brande Roderick - Robin
- Suzanne Sole - Mother
- Devin Brochu - Little Boy
- Kasey Mahaffy - Red Haired Guy
- Paul Webster - Fireman
- Jennifer Hawtrey - Customer
- David Crane
- Marta Kauffman
- Dave Finkel
- Robert Carlock
- Linda Videtti Figueiredo
- Brett Baer
- Kevin S. Bright
Ellen DeGeneres interpreta a Ellen DeGeneres en la serie.
Peter Stormare hace el papel de Viktor.
Lucy Liu hace el papel de Lauren.
George Hamilton interpreta a George Hamilton en la serie.
Matt LeBlanc interpreta a Joey Tribbiani en la serie.
Drea de Matteo interpreta a Gina Tribbiani en la serie.
Andrea Anders interpreta a Alex Garrett en la serie.
Paulo Costanzo interpreta a Michael Tribbiani en la serie.
Jennifer Coolidge interpreta a Bobbie Morganstern en la serie.
Miguel A. Núñez Jr. hace el papel de Zach Miller.
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