- Jeffrey Garcia - Sheen Estevez (voice)
- Jeffrey Garcia - Nathan (voice)
- Jeffrey Garcia - Director (voice)
- Jeffrey Garcia - Fish (voice)
- Jeffrey Garcia - Pterodactyl (voice)
- Jeffrey Garcia - Mummy #3 (voice)
- Jeffrey Garcia - Bystander (voice)
- Jeffrey Garcia - Man (voice)
- James Sie - You Yee / Elderly Monk / Ninja (voice)
- Debi Derryberry - Jimmy Neutron (voice)
- Debi Derryberry - Amber (voice)
- Debi Derryberry - Nissa (voice)
- Debi Derryberry - Mummy #1 (voice)
- Debi Derryberry - Chicks (voice)
- Debi Derryberry - Little Kid / Mother (voice)
- Debi Derryberry - Britney (voice)
- Debi Derryberry - Little Brother (voice)
- Debi Derryberry - Ultra Lord Action Figure (voice)
- Debi Derryberry - Yentl (voice)
- Peter Frampton - Hugh Neutron (singing voice)
- Ming-Na Wen - Peggy Tsu (voice)
- Tom Kane - Dean Cain (voice)
- Wendie Malick - Beautiful Gorgeous (voice)
- Christian Slater - Jet Fusion (voice)
- Jim Meskimen - Quentin Smithee (voice)
- Michael Clarke Duncan - Commander Baker (voice)
- Ben Stein - Giggles the Clown (voice)
- Mel Brooks - Santa Claus (voice)
- Phyllis Diller - Granny Neutron (voice)
- Neil Ross - Announcer (voice)
- Grey DeLisle - Sally (voice)
- Grey DeLisle - Elke (voice)
- Grey DeLisle - Mombot (voice)
- John Kassir - Seymour / Student #3 (voice)
- Tress MacNeille - Annabelle / Aunt Kari / Great Aunt Amanda (voice)
- Bill Farmer - Buford / Reporter (voice)
- Corey Burton - Rayburn (voice)
- Corey Burton - Head Monk (voice)
- Corey Burton - Dr. Dark / Pizza Monster (voice)
- Corey Burton - Spamdini (voice)
- Maurice LaMarche - Zix / Ticket Taker (voice)
- Maurice LaMarche - Goddard Digital Voice (voice)
- Maurice LaMarche - Zix / Tee / Reporter (voice)
- Michael Hagiwara - Japanese Announcer (voice)
- Michael Hagiwara - Master Hong / Ninja (voice)
- Joe Lala - Mr. Estevez (voice)
- Charlie Adler - Junkman (voice)
- Jim Cummings - Ultra Lord (voice)
- Jim Cummings - Martian #3 (voice)
- Jim Cummings - Mayor / Dog (voice)
- Jim Cummings - Mayor (voice)
- Jim Cummings - Popbot / Gortox / Goddard Speaking (voice)
- Jim Cummings - Captain Betty / Mayor (voice)
- Jim Cummings - Atila (voice)
- Jeff Bennett - Travoltron/Barbarino (voice)
- Jeff Bennett - Dr. Moist / Announcer (voice)
- Jeff Bennett - Positive Jimmy / Negative Jimmy / Macho Jimmy (voice)
- Jeff Bennett - Travoltron / Newscaster / Salesman (voice)
- Tom Kenny - Nanobot #2 (voice)
- Tom Kenny - Copbot / Interviewer (voice)
- Tom Kenny - Max / Wilderman / Mr. Moodini (voice)
- Tom Kenny - WL3000 (voice)
- Billy West - Sam Melnick (voice)
- Billy West - Sam Melnick / Corky Shimatzu (voice)
- Billy West - Sam Melnick / Man (voice)
- Billy West - Sam Melnick / Blix (voice)
- Billy West - Sam Melnick / Corky Shimatzu / Lars (voice)
- Billy West - TV Newscaster / Lucky Joe (voice)
- Billy West - Corky Shimatzu / Larry Llama (voice)
- Billy West - Sam Melnick / Lance (voice)
- Billy West - Corky Shimatzu (voice)
- Billy West - Sam Melnick / Lou / Reporter (voice)
- Billy West - Sam Melnick / Corky Shimatzu / Kid (voice)
- Billy West - Sam Melnick / Pilot (voice)
- Billy West - Blix (voice)
- Rob Paulsen - Carl Wheezer (voice)
- Rob Paulsen - Butch / Principal Willoughby (voice)
- Rob Paulsen - Principal Willoughby (voice)
- Rob Paulsen - Butch (voice)
- Rob Paulsen - Carl's Dad / Carl's Mom (voice)
- Rob Paulsen - Robo-Fiend (voice)
- Rob Paulsen - First Guard (voice)
- Rob Paulsen - Principal Willoughby / Skeet (voice)
- Rob Paulsen - Eustace Strych (voice)
- Rob Paulsen - Eustace Strych / Martian #1 (voice)
- Rob Paulsen - Pterodactyl / Chicks (voice)
- Rob Paulsen - Waiter (voice)
- Rob Paulsen - Carl's Dad / Carl's Mom / Butch / Principal Willoughby (voice)
- Rob Paulsen - Announcer / Algae Guard (voice)
- Rob Paulsen - Principal Willoughby / Oleander (voice)
- Rob Paulsen - Principal Willoughby / Ninja (voice)
- Rob Paulsen - Dad #1 (voice)
- Rob Paulsen - Carl's Dad / Carl's Mom / Butch (voice)
- Rob Paulsen - Llama / Turkey Bride (voice)
- Rob Paulsen - Cowboy (voice)
- Rob Paulsen - Evil Jimmy / Guy (voice)
- Rob Paulsen - Butch / Elf (voice)
- Rob Paulsen - Captain (voice)
- Rob Paulsen - Mort / Evil Jimmy / Romantic Jimmy / Funny Jimmy (voice)
- Rob Paulsen - Squid (voice)
- Rob Paulsen - Carl's Dad / Principal Willoughby (voice)
- Rob Paulsen - Carl's Dad (voice)
- Rob Paulsen - Banjo Boy (voice)
- Rob Paulsen - Butch / Student #1 (voice)
- Rob Paulsen - Thomas Edison (voice)
- Rob Paulsen - Llama / Butch / Squirrel (voice)
- Rob Paulsen - Principal Willoughby / Mummy #2 / Narrator / Instructor (voice)
- Rob Paulsen - Carl's Dad / Chip (voice)
- Rob Paulsen - Slick TV Pitchman (voice)
- Rob Paulsen - Oleander (voice)
- Rob Paulsen - Gus (voice)
- Rob Paulsen - Big Brother (voice)
- Kath Soucie - Betty Quinlan (voice)
- Daran Norris - Nanobot #1 (voice)
- Daran Norris - Nanobot #1 / Baby Quackers (voice)
- Candi Milo - Nick Dean (voice)
- Candi Milo - Nick Dean / Terry (voice)
- Candi Milo - Nick Dean / Britney (voice)
- Candi Milo - Nick Dean / Germy (voice)
- Candi Milo - Nick Dean / Amber (voice)
- Candi Milo - Female Fish (voice)
- Candi Milo - Nick Dean / Ignishka (voice)
- Candi Milo - Nick Dean / Phantom #1 (voice)
- Candi Milo - Britney (voice)
- Jim Belushi - Coach Gruber (voice)
- Kevin Michael Richardson - Tee (voice)
- Kevin Michael Richardson - Tremendous Jackson (voice)
- Megan Cavanagh - Judy Neutron (voice)
- Megan Cavanagh - Judy Neutron / Mrs. Vortex (voice)
- Megan Cavanagh - Judy Neutron / Woman (voice)
- Megan Cavanagh - Judy Neutron / Crowd Member #2 (voice)
- Megan Cavanagh - Judy Neutron / Vox (voice)
- Megan Cavanagh - Martian #2 (voice)
- Megan Cavanagh - Judy Neutron / Mrs. Moran (voice)
- Megan Cavanagh - Vox (voice)
- Megan Cavanagh - Judy Neutron / Gretchen (voice)
- Megan Cavanagh - Mrs. Vortex / Vox (voice)
- Megan Cavanagh - Judy Neutron / Old Lady Nusbaum (voice)
- Megan Cavanagh - Judy Neutron / Mrs. Vortex / Aunt Suzy (voice)
- Megan Cavanagh - Judy Neutron / Masseuse / MaternoTron (voice)
- Megan Cavanagh - Judy Neutron / Girl (voice)
- Megan Cavanagh - Judy Neutron / Mrs. Pizza Monster (voice)
- Megan Cavanagh - Judy Neutron / Hilgo (voice)
- Megan Cavanagh - Judy Neutron / Phantom #3 (voice)
- Megan Cavanagh - Judy Neutron / Lunch Lady (voice)
- Paul Greenberg - Brobot (voice)
- Paul Greenberg - Brobot / Man on TV (voice)
- Mark DeCarlo - Hugh Neutron (voice)
- Mark DeCarlo - Hugh Neutron / General / Alien Man / Emergency System / Gleason Like Creature (voice)
- Mark DeCarlo - Hugh Neutron / Man (voice)
- Mark DeCarlo - Hugh Neutron / Commercial Narrator (voice)
- Mark DeCarlo - Hugh Neutron / Clerk (voice)
- Mark DeCarlo - Hugh Neutron / TV Announcer (voice)
- Mark DeCarlo - Hugh Neutron / Instructor (voice)
- Mark DeCarlo - Hugh Neutron / Announcer (voice)
- Mark DeCarlo - Hugh Neutron / Mr. Vortex (voice)
- Mark DeCarlo - Hugh Neutron / Eddie / Newt / Gomer (voice)
- Mark DeCarlo - Hugh Neutron / Octopus Man (voice)
- Mark DeCarlo - Hugh Neutron / Jenson / Skeezicks (voice)
- Mark DeCarlo - Hugh Neutron / Flippy (voice)
- Phil LaMarr - Bolbi (voice)
- Phil LaMarr - Bolbi / TV Announcer (voice)
- Phil LaMarr - Bolbi / Toy Executive (voice)
- Phil LaMarr - Bolbi / Pitz / Teenager (voice)
- Tim Curry - Professor Calamitous (voice)
- Frank Welker - Goddard / Special Vocal Effects (voice)
- Frank Welker - Goddard / Phantom #4 / Special Vocal Effects (voice)
- Frank Welker - Special Vocal Effects (voice)
- Frank Welker - Goddard / Tubbs / Special Vocal Effects (voice)
- Frank Welker - Goddard / Tubbs / Health Inspector / Special Vocal Effects (voice)
- Frank Welker - Goddard / Second Guard / Special Vocal Effects (voice)
- Frank Welker - Goddard / Wendel / Special Vocal Effects (voice)
- Frank Welker - Goddard / Tubbs / Father / Special Vocal Effects (voice)
- Frank Welker - Tubbs / Special Vocal Effects (voice)
- Frank Welker - Goddard / Mr. Strych / Special Vocal Effects (voice)
- Frank Welker - Goddard / Mr. Wuggles / Special Vocal Effects (voice)
- Crystal Scales - Libby Folfax (voice)
- Crystal Scales - Libby Folfax / Chuck (voice)
- Crystal Scales - Libby Folfax / Ike (voice)
- Crystal Scales - Libby Folfax / Libby's Mom (voice)
- Crystal Scales - Libby Folfax / Maggie (voice)
- Crystal Scales - Libby Folfax / Phantom #2 (voice)
- Crystal Scales - Libby Folfax / Student #2 (voice)
- Crystal Scales - Libby Folfax / Ozzie (voice)
- Crystal Scales - Libby Folfax / Libby's Brother (voice)
- Crystal Scales - Libby Folfax / Chicks (voice)
- Andrea Martin - Ms. Fowl (voice)
- Andrea Martin - Ms. Fowl / Lady (voice)
- Edie McClurg - Grandma Taters (voice)
- Carolyn Lawrence - Cindy Vortex (voice)
- Carolyn Lawrence - Cindy Vortex / Tina Sue (voice)
- Carolyn Lawrence - Cindy Vortex / Yuri (voice)
- Carolyn Lawrence - Cindy Vortex / Phantom #2 (voice)
- John A. Davis
- Keith Alcorn
- Steve Oedekerk
- Charlie Brissette
Edie McClurg hace el papel de Grandma Taters (voice).
Christian Slater hace el papel de Jet Fusion (voice).
Dan Castellaneta hace el papel de Professor Crank (voice).
Debi Derryberry interpreta a Jimmy Neutron (voice) en la serie.
Jeffrey Garcia interpreta a Sheen Estevez (voice) en la serie.
Rob Paulsen interpreta a Carl Wheezer (voice) en la serie.
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