- Ryan Devlin - Billy Cordero
- Alano Miller - Roman Zazo / Aaron Zazo
- Anton Narinskiy - Adonis
- Carmen Carrera - Eva
- Donna Pieroni - Nurse Sharon
- Greice Santo - Blanca
- Will Beinbrink - Club Manager
- Carlo Rota - Emilio Solano
- Azie Tesfai - Nadine Hansan
- Camille Collard - Frankie
- Brian Dare - Luca
- Montse Hernandez - Teenage Jane
- Butch Klein - Jim
- Stacie Greenwell - Sonogram Technician
- Bart Braverman - Priest
- Ethan Harris-Riggs - Teenage Boyfriend
- Michael Rady - Lachlan Moore
- Tony Plana - Father Ortega
- Tina Casciani - Melissa De La Vega
- Greg Collins - Lieutenant Armstrong
- Christopher Corbin - Ivan
- David Castañeda - Nicholas
- Skylar T. Adams - Tom
- Susan Flynn - Roxanna
- Jaret Sacrey - EMT
- Joe Souza - Male Executive
- Leslie Simms - Sister Margaret
- Willow Geer - Sister Theresa
- Vanessa Merrell - Valeria
- Veronica Merrell-Burriss - Victoria
- Beth Hall - Olivia
- Aria Pullman - Hot Band Leader
- Fernando Aldaz - Telenovela Male Star
- Crystal Mantecon - Telenovela Female Star
- Nicholas Gonzalez - Marco Esquivel
- Tiffany Panhilason - Erika
- Frank Maharajh - Mr. Flanagan
- Jamila Webb - Nora
- Michael Hyland - Ben
- Craig Welzbacher - Waiter
- Juanes - Elliot Lantana
- Julie Berman - Candyce
- Kevin Ashworth - Mr. Asterly
- Michelle Bonilla - Ms. Rivas
- Alli Kinzel - Waitress
- Adrian Bustamante - Manager
- Rose Colasanti - Housekeeper
- Paulina Rubio - Herself
- Max Bird-Ridnell - Milos
- Keller Wortham - Esteban Santiago
- Marlene Favela - Best Supporting Actress
- Joey Lanai - Male Presenter
- Melissa Marty - Miami News Anchor
- Shelley Robertson - Gillian
- Jill Remez - Lawyer
- Vanessa Mizzone - Sonogram Technician
- Marek Matoušek - Czech EMT
- Aaron Krebs - Forensic Technician
- Keisuke Hoashi - Dr. Elliot
- Layla Alizada - Regina
- Tammy Caplan - Betty
- Elena Campbell-Martinez - Nurse
- Michael Christian Alexander - News Anchor
- Alex Loynaz - Steven
- Will Bethencourt - Ricky
- Charles Hoyes - Contractor
- Jonathan Cahill - Shifty Worker
- Paul Kim Jr. - Dr. Huang
- Jack Guzman - Dean
- Michelle N. Carter - Nurse
- Wes Armstrong - Scott
- Jamie Rose - Therapist
- Cheech Marin - Edward
- Rachel DeGenaro - Sonogram Technician
- Paul Nobrega - Dr. Hillcroft
- Ursula Burton - Danielle Sullivan
- Alex Lombard - Whitney Devore
- Michael Broderick - Guard
- Rolando Boyce - Cop
- Donnabella Mortel - Nurse
- Gabriela Fresquez - Physical Therapist
- Claude Knowlton - Gabriel
- Nick Hart - Dan
- Sylvia Panacione - Chelsea
- Kamilla Alnes - Woman
- Kathleen York - Angelique Harper
- Arianna Ortiz - Fiona
- Jeffrey De Serrano - Alex
- Josh Evans - Line Cook
- Ryan W. Garcia - Javier
- David Bisbal - Himself
- Kathleen Wilhoite - Wendy
- Rachel DiPillo - Andie
- Jane Seymour - Amanda Elaine
- Bella Popa - Shelly
- Christopher Amitrano - Tony Vaughn
- Chris Aquilino - Beau
- Elaine Loh - Gretchen
- Mario Corona - Churro Guy
- Allen Walls - Wendy's Husband
- Kristen O'Meara - Leah
- Brien Perry - Officer J. Harris
- Melinda Page Hamilton - Alexis Falco
- Fabiana Udenio - Elena Di Nola
- Rita Moreno - Liliana De La Vega
- John Burke - Graham
- Isabella Camil - Flavia
- Simona Williams - Irene
- Jessica Gardner - Instructor
- Jesus Ruiz - Priest
- Nia Vardalos - Barbara
- Sarah Benoit - Nun
- Eugene Young - Tech Guy
- Jessica Chow - Photographer's Assistant
- Susan Ortiz - Doctor Soriano
- Diane Guerrero - Lina
- Diane Guerrero - Lina Santillan
- Mariah Buzolin - Stephanie
- Michael Galante - Alex Mendez
- Karl T. Wright - Mr. Baird
- Samantha Esteban - Captain Garcia
- Amanda George - Taylor
- Chelsea Alden - Winnie
- Lucas Kwan Peterson - Photographer
- Darin Toonder - Mitchell Murray
- Ray Garcia - Choreographer
- Nicole J. Butler - Gabrielle
- Andrew Lee - Man on the Bus
- Lynn Adrianna - Nosy Woman
- Garret Davis - Vet on the Bus
- Jim Wilkey - Bus Driver
- Carlos Alazraqui - Dr. Moncada
- Chad Michaels - Cher Impersonator
- Marypat Farrell - Nurse
- Hira Ambrosino - Dr. Pelgado
- Mustafa Speaks - Policeman
- Stephanie Maura Sanchez - Dr. Saltillo
- Lorena Jorge - Fan #1
- Elia Saldana - Fan #2
- Whitney Avalon - Anxious Receptionist
- Carrie Madsen - Diane
- Fernando Rivera - Medical Resident
- Oliver Vaquer - Professor Blake
- Bob Clendenin - Bar Patron
- Jim Boeven - Henchman #1
- Carol Avery - Banker
- Jason Rosenwach - Bellboy
- Ana Dela Cruz - Dr. Garcia
- Rachel Axelrod - Kai
- Crystal Marie Denha - Miami Reporter
- Cheyenne Wilbur - Monk 1
- Eddie Santiago - Monk 2
- Kelly King - Crystal
- Kesha - Annabelle
- Jason Boegh - Director
- Tahlena Chikami - Isabelle
- Fawnda McMahan - UPS Woman
- Melissa Jobe - Alice
- Brad Lee Wind - Officer A. Wolf
- Kate del Castillo - Luciana Leon
- Al Coronel - Dr. Peters
- Clint Glenn Hummel - Anton
- Christopher Carroll - Gustav
- Helen Wilson - Clothilde
- Chris Dougherty - Forensic Linguist
- Claudia de Vasco - Instructor
- Katherine Boecher - Henry's Mom
- Sarah Buehler - Lily's Mom
- Diahnna Nicole Baxter - Lecturer
- Megan Ketch - Susanna Barnett
- Linn Bjornland - Heidi Von Ocher
- Sandra Seeling - Gerta
- Samantha Eggers - Birgit
- Sara Erikson - Instructor
- Marcus Anderson - Bicyclist
- Norma Maldonado - Director
- Britney Spears - Britney Spears
- Kaiwi Lyman - Zed
- Christopher Salazar - Attorney Robert Torres
- Hugh Holub - Officiant
- Jonathan Ohye - Eric Wu
- Adam Rodriguez - Jonathan Chavez
- Julianna Barninger - Junior Network Executive
- Jelena Nik - Mary
- Zabeth Russell - Nurse
- Yemi Cole - Student #1
- Jeff DeCrosta Jr. - Student #2
- Joyful Drake - Dr. Bolton
- Julia Farino - Too-Strict Babysitter
- Roni Geva - Too-Crunchy Babysitter
- Skyler Hart - Hot Manny
- Duncan Joiner - Tyler
- Chanel Minnifield - Student #5
- Eduardo Roman - Male Director
- Ravi Naidu - ER Doctor
- Megan Park - Dr. Damprey
- Jorge Diaz - JD Guzman
- Brian Jordan Alvarez - Wesley
- Lillianna Valenzuela - Little Girl Jane / Young Jane / 7-Year-Old Jane
- Melissa Ciesla - Nosy Mom
- John Salley - John
- Lee Reherman - Lee
- Chad James Buchanan - McBaskets
- Erinn Westbrook - Natalie Tanner
- Mercedes Colon - Freda Alonso
- Armando Molina - Byron
- Jason Woods - McBaskets' Teammate
- Amaris Davidson - Perky Instructor
- Don Creech - Henry
- Doris L. Guerrero - Policewoman
- Diego Boneta - Dax
- Jose Moreno Brooks - Greg
- Angie Cepeda - Adriana Chavando
- Justin Chu Cary - Guy #1
- Corey Martin Craig - Guy #3
- Tonatiuh Elizarraraz - Javi
- Joseph Ferrante - Guy #2
- Bret Green - Brad
- Nishi Munshi - Izzie Hillcroft
- Paolo Andino - Diego
- Catherine Toribio - Teen Xiomara
- Catherine Toribio - Young Xo
- Salome Azizi - Julie
- Michelle Castillo - Costumer
- Lyle Kanouse - Joey
- Jully Lee - Zoe
- Graham Clarke - Gus
- Jon Klaft - Waiter
- Emebeit Beyene - Waitress
- Alvaro Martinez - Child
- Casey Nelson - Cop
- Clinton Jackson - Swat Captain
- Cynthia Quiles - Intern
- Ana de la Reguera - Paola
- Julie Pearl - Account Exec
- Doris Morgado - Estela
- Justin Cuomo - Detective #2 / Passing Cop
- Shvona Lavette Chung - Avery Van Allen
- Eileen Fogarty - Woman In Line
- Uma Incrocci - Another Woman In Line
- Henry Barrial - Dr. Grove
- Hina Khan - Front Desk Clerk
- Leah Briese - Another Woman
- Bianca Lopez - Nurse
- José Díaz-Balart - Himself
- Daniel Roebuck - Michael Cordero Sr.
- Molly Hagan - Patricia Cordero
- Mat Vairo - Derek
- Marcelo Tubert - Pablo Alonso Segura
- Alison Fernandez - Young Jane
- Claudia Zielke - Nurse Wilma
- Iris Almario - Soledad Goldberg
- Christine Alicia Rodriguez - Student
- Jenn Liu - Hospital Nurse
- Charo - Herself
- Amy Higgins - Contractor
- Gabriela Banus - Marie Antoinette
- Kim Yarbrough - Fan
- Kim Yarbrough - Judge
- Ricardo Mamood-Vega - Louis XVI
- Devin Sidell - Charlie's Mom
- Susan Huckle - Sophia's Mom
- Kelly Pendygraft - Alice
- Charlyne Yi - Angela
- Joseph Piccuirro - Trevor
- Will Brandt - Chad
- Benjamin Hjelm - Brandon
- Derek Hough - Salsa Dancer
- Senta Moses - Tammy
- Cate Cohen - Senior Network Executive
- Ada Luz Pla - Telemasivo V.P.
- Kathryn Winslow - Saleswoman
- Catherine Taber - Woman
- Preston James Hillier - Officer
- Judy Kain - Barbara Fairwick
- Zailee Madrigal - Juanita
- Dyana Ortelli - Alma
- Kikey Castillo - Xaviera
- Lidia Porto - Chepa
- Tina Morasco - Mrs. Hutchinson
- Kelli Kirkland - Eileen Hatcher
- Jesus Guevara - FDR
- Ben Belack - Customer #1
- Caryn Ward - Customer #2
- Kenny Kelleher - Customer #3
- Marri Savinar - Lilah
- Daniel Kash - Dr. Spinoza
- Elisabeth Röhm - Eileen
- Johnny Messner - Chuck
- Evan Todd - Jeremy Howe
- Francisco San Martin - Fabian
- Galicia Vaca Lopez - Female Employee
- Phil Tyler - Cop
- David Haley - Another Cop
- Tyler Posey - Adam
- Kimberlee Kidd - Pretty Teenager
- Madison Rojas - Five-Year-Old Mateo
- Tony Evangelista - Prankster Cop
- Philip Boyd - Handsome Guy on Bus
- Alec Mapa - Aguilar
- Katherine Castillo - Younger Xiomara
- Edward Padilla - Actor Priest
- Jordan Diambrini - Superfly Date
- Andrey Ivchenko - Danek
- Omar Chavez - Frantic PA
- René Ashton - Cop
- Jalene Goodwin - Bride
- Holger Moncada Jr. - Nearby Grip
- Madeline Bertani - Nosy Girl
- Ava Davila - Future Sex-Year-Old Daughter
- Duvier Poviones - Bogelio
- Michael Minto - Student #4
- Daisy McCrackin - Other Mommy
- Blaine Allen - Nadine's Mother
- Brent Popolizio - Courier
- Medalion Rahimi - Hot Girl
- Dominique Generaux - Female Employee
- Clint Carmichael - Executive
- Isaac Stephen Montgomery - Bouncer
- Sabrina Perez - Female Presenter
- Jesse D. Goins - Minister
- Maite Garcia - Dr. Perez
- Pamela Bell Mitchell - Dean's Assistant
- Christopher Boyer - Santa Claus
- Chiquita Fuller - Nurse #1
- Emanuel Loarca - Nurse #2
- Kate Butler - Hospital Administrator
- Charles Kim - Dr. Hamagaki
- B.J. Clinkscales - Police Officer #2
- Aiden Lewandowski - Young Rogelio
- Karole Foreman - Nurse
- Maria McCann - Doctor
- Maggie Gwin - Swim Instructor
- Bruno Amato - Security Guard
- Victoria Garcia-Kelleher - Segment Producer
- Carla Lomelín - Woman
- Peter Cornell - Donny
- Michelle Twarowska - Nurse Helga
- Jenn An - Engineer
- Felice Heather Monteith - Nurse Patricia
- David Goldman - Guest #1
- Nicola Lambo - Guest #2
- Bernard Bullen - Columbus
- Lex Medlin - Jerry
- Debbie Allen - Beverly Flores
- Jami Ferreira - Rhonda
- Matthew Patrick Davis - Bobby
- Mallory Low - Young Woman
- Mary Eileen O'Donnell - Elderly Librarian
- Carlos Montilla - Cesar Chavez
- Gina St. John - E.R. Doctor
- Adrian Quinonez - Nurse
- Samantha Cutaran - Hostess
- Annie Little - Vanessa
- John Starr - Carl the Clown
- Stephen Weigand - FBI Agent #1
- Sydney Viengluang - FBI Agent #2
- Alex Fernandez - Father Gustavo
- Bruno Mars - Himself
- Philip Lawrence - Himself
- Stephen R. Hudis - Bus Driver
- Louise Barnes - Doctor
- Rogelio T. Ramos - Priest
- Vivis - Mateo's Aunt
- Laura Cordova - Alba's Mom
- Marcos De Silvas - Mateo's Uncle
- Manuel Urrego - Alba's Uncle
- Tonya Kay - D.J.
- Russell Pitts - Nick
- Miles Gaston Villanueva - Sam
- Christopher Allen - Dennis
- Lizz Carter - Layla Vane
- Carla Vega - Detective Oliva
- Patrick Cage - Officer Knapp
- Sebrina Purcell - Female Cop
- Lisagaye Tomlinson - Doctor Lewis
- Rishi Arya - Doctor Sterling
- CJ Ramirez - Fan #1
- Brennan Murray - Fan #2
- Corey Clifford - Female Nurse
- Shirell Ferguson-Coleman - Another Female Nurse
- Steven Allerick - Male Nurse
- Tamra Meskimen - Nearby Woman
- Jason Sims-Prewitt - Nurse
- Raquel Montero - Emma Lazarus
- Doreen Calderon - Preschool Supervisor
- Tarina Pouncy - School Director
- Kate Orsini - Snooty Mom
- Terryn Westbrook - Teacher
- Robert Burgos - White Judge #1
- Blaine Gray - Michael's Doctor
- Gloria Estefan - Self
- Emilio Estefan Jr. - Self
- Victor Manso - Freddy
- Andrea Lareo - Coco
- Alison Whitney - Young Producer
- Eric Emmanuel - Sergio
- Hal Devi - Mover
- Anna Campbell - Female Executive
- Shay Ali - Male Executive
- Renato Powell - Guard
- Dot-Marie Jones - Magda's Friend
- Jessica Caban - Sonia
- Scott Michael Morgan - Property Manager
- Shannon McClung - Man
- Annie Korzen - Mrs. Cohen
- Donnell Turner - Handsome Costumer
- Emily Baldoni - Classmate
- Emily Baldoni - Runner Friend
- John O'Leary - Old Man
- Melody Peng - Caitlyn
- Michael James Lazar - Security Guard
- Estefania Rebellon - Alejandra
- Michelle Jubilee Gonzalez - Julia
- Sofia Pernas - Catalina
- Amanda Westlake - Woman
- Bonnie Kolber - Nurse
- Kelly Rutherford - Leslie
- Ricardo Chavira - Bruce
- Kara Wang - Alice
- Kelli Erdmann - Teen Dancer #1
- Ashlei Foushee - Teen Dancer #2
- Maahra Hill - HBO Rep
- Denise Richards - Self
- Carmen Electra - Self
- Brooke Burke - Self
- Irene DeBari - Mother Constantine
- Kassandra Voyagis - Young Sister Constantine
- Jill Basey - Random Nun
- Marion Kerr - Sister Julia
- Mari Weiss - Sister Monica
- Irina Maleeva - Nun
- Richard Shelton - Arnaud
- A.J. Tannen - Garret
- A.J. Tannen - Businessman
- Mandy Levin - Laura
- Stephanie Koenig - Host
- Mike Rylander - Rude Man
- Castulo Guerra - Grandpa De La Vega
- Castulo Guerra - Manuel De La Vega
- Dannay Rodriguez - Tess
- Jared Boghosian - Indie Film Director
- McNally Sagal - Allison
- Sarah Jorge - Adriana
- Craig Ng - Shaman
- Fionn James - Teenage Mateo
- Angela Fornero - Chauncy's Mom
- Tiffany Yvonne Cox - Tanya
- Dru Mouser - Impressed Mom
- Jon-Mark Hurley - Impressed Dad
- Nikhil Pai - Waiter
- Maya Kazan - Chloe Leland
- Joe LoCicero - Don Quixote Stripper / Prince Charming Stripper / Masked Figure
- Joe LoCicero - Alien Soldier Man
- Joe LoCicero - Blooki
- Cheryl Burke - Self
- James William O'Halloran - Male Model
- Landen Beattie - Seven-Year-Old Michael
- Angela Landis - Paparazzo
- Minka Kelly - Abbey Whitman
- Alison Trumbull - Jackson's Mom
- Clint Jung - Sensei
- Devin Crittenden - Swashbuckling Swan
- Christina DeRosa - Astrid
- Mercedes Cornett - Isla
- Elizabeth Hinkler - Event Assistant
- Kelly LaMarr - Inspector
- Phillip Jordan - Van
- Scarlett Fernandez - Kid
- LeShay N. Tomlinson - Director
- Katie Adler - Pammy the Parrot
- Nadine Ellis - Jane's Therapist
- Craig Lee Thomas - Elvis
- Mat Hayes - Upset Dad #1
- Rudy Martinez - Production Assistant
- Rudy Martinez - Rudy
- Rudy Martinez - Rudy the PA
- Rudy Martinez - Rudy the P.A.
- Daniel Robaire - Upset Dad #2
- Christopher Cho - Gary Huang
- Corbin Mayberry - Messenger
- Yvonne Orji - Stacy
- Danny Woodburn - Donnie Shapiro
- Mackenzie Marsh - Carly
- Stephanie Nash - Gwen
- Dexter Masland - Waiter #1
- Christopher Gerse - Waiter #2
- Christopher Farrar - Little Kid
- Angela Oh - Moderator
- Deniz Akdeniz - Alex
- Sheila Carrasco - Dana
- Krizia Bajos - Caroline
- Madia Hill Scott - Nearby Mom
- Paul Toweh - Young Barista
- J.D. Hinton - Announcer
- Gloria Calderón Kellett - Senior Network Executive
- Richard Varga - Vice President
- Carla Vila - Director
- Tacey Adams - Judge
- Adwin Brown - Mini-Golf Manager
- Maria Semple - Herself
- Talia Toms - Mother
- Diana Solis - Female Telenovela Star
- Reinaldo Zavarce - Male Telenovela Star
- Nakia Burrise - Female Executive
- Orestes Arcuni - Male Executive
- Rachel Rosenbloom - Fan
- Joshua Chang - Danny Zhao
- Shalin Agarwal - Farouk
- Alejandra Flores - Lorena
- Julie Lancaster - Customer
- Ben Faigus - Waiter
- Silvia Curiel - Señora Belen
- Tiffany Smith - Telemasivo Reporter
- Jay Montalvo - Priest
- Natalia Herrera - Reporter #1
- Daniel Montgomery - Jean
- Matthew Scott Montgomery - Luc
- Reagan To - Little Kid
- Ty Mayberry - Weatherman
- Ungela Brockman - Lawyer
- Nardeep Khurmi - Husband
- Brenda Arteaga-Walsh - Wife
- Eric M. Myrick - Valet
- James Quattrochi - Bus Driver
- Ilka Urbach - Guard
- Vanessa Marshall - Latina Lover Narrator (voice)
- Hawk Walts - Henchman
- Reece Frith - Marbella Valet
- Alex Meneses - Katherine Cortes
- Andrew Callahan - Flaco
- Howard Chan - Dr. Nguyen
- Diana de la Cruz - Middle-Aged Woman
- Alyssa Gabrielle Rodriguez - Moderator
- Ana Rey - Pilar
- Reem Kadem - Dr. Ghazali
- Graham Sibley - Carl
- Heather Olt - Doula
- Reinaldo Faberlle - Huge Man
- Jon Reep - Fumigator
- Paul Haitkin - Dr. Bennett
- GiGi Erneta - Lawyer
- Julien Ari - Mario
- Augustine Hargrave - Waiter
- Becki Dennis - Justine
- Connie Jackson - Nurse
- Andrew Heder - Groomsman 1
- Michael Meir Saltzman - Groomsman 3
- Shawn Singh - Groomsman 4
- Rudy Quintanilla - Enrique
- Isabel Allende - Isabel Allende
- Juan Alfonso - EMT
- Flor de Maria Chahua - Another EMT
- Iyanla Vanzant - Iyanla Vanzant
- Conroe Brooks - Delivery Guy
- Stephanie Czajkowski - Delivery Woman
- Maria Carmen - Moderator
- JoAnna Rhambo - Audience Member
- Cherish Monique Duke - Fan
- Shannon Burwell - Another Fan
- Erich Lane - Bellboy
- Osa Wallander - Velma
- Azur-De - Savannah's Mom
- Angela Martinez - Female School Official
- Fiona Rene - Celeste
- A Leslie Kies - Dana
- Jacqueline Mazarella - Therapist
- Atticus Batacan - Man
- Mark Collier - Slick Lawyer
- Chad Yazawa - Mailman
- Sohm Kapila - Leslie
- Karen Lew - Mateo's Teacher
- Gloria Laino - Aida
- Vera Taylor - Woman
- Charles Michael Davis - Jeffrey Mullins (uncredited)
- Julie Chen Moonves - Julie Chen Moonves
- Sara Gilbert - Sara Gilbert
- Sharon Osbourne - Sharon Osbourne
- Sheryl Underwood - Sheryl Underwood
- Eve - Eve
- Michael Hagiwara - Bob
- Jeff Holman - Vinnie
- Drew Fonteiro - Chris
- Jack Landron - Ronaldo
- Brad Gage - Young Dad
- Jason Medwin - Delivery Man
- Eva Longoria - Herself
- George Akram - Brad
- Judy Reyes - Dina Milagro
- Judy Reyes - Dina Milagro (uncredited)
- Lexi Flores - Assistant 1
- Lauren McCarroll - Assistant 2
- Abigaille Ozrey - Assistant 3
- Gregory Sims - Angry Customer
- Brittney Bertier - Tara
- Jana Lee Hamblin - Female Exec
- Juan Monsalvez - Male Exec
- Bayley Corman - Marissa
- Yolanda Snowball - Clerk
- Bee-Be Smith - Professor Henderson
- Romel de Silva - Student
- Sean Spann - Professor
- Adam J. Smith - Real Estate Manager
- Baadja-Lyne Odums - Nurse
- Sean Samuels - Instructor
- Clayton Farris - Improv Teacher
- Billy Meade - Mario
- Patrick Cronen - Jay
- Greg Audino - Bellboy
- Christopher Goodman - Doctor
- Iyari Limon - Allison
- Chloe Fineman - Assistant
- Julio Macias - Male Student
- Sharon Im - Another Student
- Stacey Moseley - Doctor
- Alex Smith - Waiter
- Angélica Vale - Marisol
- Courtney Henggeler - Satchet
- Kayla Chavez - 8 Year Old Xiomara
- Cali DiCapo - Young Jane
- Cali DiCapo - 9 Year Old Jane
- Cali DiCapo - 11 Year Old Jane
- Mandy June Turpin - Dr. Robin Ducard
- Feodor Chin - Dr. Park
- Brian Maillard - Sales Clerk
- Mario López - Himself
- Helen Hong - Felicia
- Gia Lopez - Gia
- Nick Echols - Second Immigration Officer
- Rueben Grundy - Cop
- Rueben Grundy - Junior Studio Executive
- Constanza Palavecino - Victoria
- Andres Mejia - Arturo's Mother
- A.J. Rivera - Employee
- Amy Brenneman - Donna
- Jeirmarie Osorio - Telenovela Fan
- Harvey J. Alperin - Vendor
- Mara Casey - Nurse
- Mina Joo - Costumer
- Priscilla Barnes - Magda
- Anthony Mendez - Narrator (voice)
- Rosie Garcia - Young Alba
- Dennis Mencia - Young Mateo / Mateo Sr.
- Mia Allan - Anna
- Julianna Gamiz - 5 Year Old Jane
- Apollonia Pratt - 4 Year Old Xiomara / Young Xo
- Shelly Bhalla - Krishna
- Shelly Bhalla - Krishna Dhawan
- Carrie Gibson - Officiant
- Bobo Chang - Waiter
- Bobo Chang - Server
- Bradley Bundlie - Boy in Elevator (uncredited)
- Rick Malambri - Keith
- Leigh Bush - Lisa
- Francesca Santoro - Young Elena
- Ella Allan - Ellie
- Ella Allan - Ellie Solano
- Sophia Bush - Julie
- Brooke Shields - River Fields
- Bridget Regan - Rose Solano
- Enzo Rodriguez - Classmate / Earth Kid (uncredited)
- Tommy Dorfman - Bobby
- Soni Bringas - Hip-Hop Dancer (uncredited)
- Yara Martinez - Dr. Luisa Alver
- Rosario Dawson - Jane "JR" Ramos
- Rosario Dawson - Jane Ramos
- Claire Friesen - Performer (uncredited)
- Melanie Mayron - Marlene Donaldson
- Jenna Ortega - Young Jane
- Justina Machado - Darcy Factor
- Justina Machado - Darci Factor
- Alfonso DiLuca - Jorge
- Alfonso DiLuca - Jorge Garcia
- Doug Locke - Morgan
- Russell Thomas - Vitamin Man
- Lauren Daisy White - Telenovela Star (uncredited)
- Brittani Ebert - Polly
- Noel Arthur - Dr. Sutker
- Amir Khalighi - Cop
- Kelby Joseph - Mover
- Alison Yates - Production Coordinator
- Ericka Kreutz - Hannah
- Hymnson Chan - Writer
- Payson Lewis - Writer
- Nick Bush - First AD
- Donielle Artese - Director
- Miles Dausuel - Barista
- Lorenzo Lamas - Lorenzo Lamas
- Crystal-Lee Naomi - Desk Clerk
- Timothy E. Goodwin - Bus Driver
- Alyssa Preston - Stern Woman
- Patrick Cox - Steve the Mailman
- Akrosia Samson - Doctor
- Mendel Fogelman - Marbella Employee
- Kara Pacitto - Adult Anna
- Zelda Williams - Leona
- Jim Hanna - Immigration Official
- Emma Fassler - Waitress
- Lana Danielyan - Lookalike
- Vico Ortiz - Lookalike
- Brittini London - Bartender
- Bo Kane - Rick
- Steven Lee Allen - Cowboy
- Aaron G. Chayrez - Ranch Hand
- Justin Hartley - Justin Hartley
- Gigi Bermingham - Female Network Exec
- Matthew Rocheleau - Male Network Exec
- Jodi Harris - Ms. Everette
- Alfred Woodley - Head of Hotel Security
- Nicole Picard - Female Examiner
- Brian Oblak - Male Examiner
- Marie Del Marco - Hotel Maid
- Sandra Cevallos - Dr. Flores
- Jeff Witzke - Kenny
- Matthew Isaac Harris - Male Reporter
- Eden Sher - PJ
- Ralph Cole Jr. - Sales Clerk
- Julian Silver - Temp
- Arber Mehmeti - Investor
- Aaron W Reed - Laird
- Chieko Hidaka - Woman
- Roel Navarro - Mateo Sr.
- Tiffany Jeneen - Courthouse Official
- Ludo Lefebvre - Ludo Lefebvre
- Larry Sullivan - Rev. Richard Fairdale
- Shireen Crutchfield - Mom
- David L. King - Dr. Price
- Leslie Ishii - Nurse
- Julia Parker - Snooty Woman
- Josh Latzer - Guard
- Emmy Raver-Lampman - Lily Lofton
- Jaime Schwarz - Jemma
- Tia Valentine - Taylor
- Olivia d'Abo - Clarissa
- Ryan Anderson Lopez - 6 Year Old
- Freddy John James - Marbella Guard
- Alice Rietveld - Female Cop
- Vic Stagliano - Prison Warden
- Vic Stagliano - Warden Kelly
- Teri Andrzejewski - Yoga Instructor
- Anna Lillie - Alien Woman
- Itziar Martinez - Woman
- Jennie Snyder Urman - Self / Executive Producer
- Ray Reynaga - Worker
- Cheryl Francis Harrington - Chantelle
- Mell Bowser - Nick
Castulo Guerra hace el papel de Manuel De La Vega.
Sara Gilbert interpreta a Sara Gilbert en la serie.
Don Creech hace el papel de Henry.
Gina Rodriguez hace el papel de Jane Villanueva.
Andrea Navedo hace el papel de Xiomara Villanueva.
Yael Grobglas interpreta a Petra Solano en la serie.
Justin Baldoni interpreta a Rafael Solano en la serie.
Ivonne Coll hace el papel de Alba Villanueva.
Jaime Camil hace el papel de Rogelio De La Vega.
Capítulo disponible en las siguientes plataformas:
