- Julia Sawalha - Rachel
- Perry Fenwick - Jimmy
- Derek Fowlds - Kurt Friedman
- Rachel Weisz - Arabella Baydon
- Jacqueline Leonard - Miss Sarah Spillers
- Brian Cox - Michael Steppings
- Jean Anderson - Lady Hinksey
- Dominic Keating - Murray Stone
- Peter Blythe - Kenneth Lawrence
- Sukie Smith - Lorraine
- Suzanna Hamilton - Emma Cryer
- Seeta Indrani - Laboratory Assistant
- Tenniel Evans - Dr. David Kerridge
- Barbara Flynn - Monica Height
- Judy Campbell Exner - Mrs. Rawlinson
- Adam Morris - Constable Dixon
- Su Elliot - Mrs. Hart
- George Irving - George Henderson
- Daniel Massey - Anthony Donn
- Barbara Leigh-Hunt - Blanche Copley-Barnes
- Lisa Harrow - Thelma Radford
- Jake Wood - Jimmy
- Tip Tipping - P.C. Dene
- Sam Kelly - Walter Majors
- Kenneth Haigh - Freddie Galt
- Ian Sharp - First Angler
- Noah Taylor - Dave Harding
- Dicken Ashworth - George Drummond
- Peter McEnery - Donald Phillipson
- Amanda Wenban - Typist
- Amanda Burton - Mirella Lunghi
- Elspet Gray - Mrs Bartlett
- Julie Legrand - Brigitte de Plessy
- David Haig - Peter Rhodes
- Frances Barber - Nicole Burgess
- Charlotte Coleman - Jessica White
- Robert Pugh - Geoff Harris - Prison Officer
- Anna Chancellor - Sally Smith
- Claire Skinner - Girl Pupil
- Gertan Klauber - German Man
- Michael Hordern - Doctor Starkie
- Rupert Holliday-Evans - David
- Nicky Henson - Vince Cranston
- Gavin Richards - Steven Trevors
- Ivor Roberts - Mr. Waugh
- George Costigan - Ron Garrett
- Betty Marsden - Cynthia Preece
- Al Hunter Ashton - Detective
- Ian McDiarmid - Hugo De Vries
- Kenneth Colley - DCI Patrick Dawson
- Peggy Mount - Nun
- Eileen Way - Mrs Papas
- Max Phipps - DI Glenn McAllister
- Philip Locke - Freddie Mortimer
- Frances Tomelty - Grace Craven
- Ian Bleasdale - Time and Motion Expert
- Clive Swift - Dr Bartlett
- Sheila Gish - Gwladys Probert
- Patrick Godfrey - Dr. Greer
- Michael Culver - Maugham Willowbank
- Samantha Bond - Helen Marriat
- Michael Kitchen - Russell Clark
- Rupert Graves - Billy
- Christopher Benjamin - Professor Furlong
- Patricia Hodge - Lady Hanbury
- Beatie Edney - Deborah Burns
- Anna Calder-Marshall - Jane Robson
- Kenneth Cranham - Cedric Downes
- John Normington - Lionel Pawlen
- James Laurenson - Tony Richards
- Stephen Moore - Radio Producer
- Marion Bailey - Fran Pierce
- Penny Downie - Nurse Wendy Hazlitt
- Cheryl Campbell - Sylvie Maxton
- Alex Jennings - Victor Preece
- Patrick Malahide - Jeremy Boynton
- Mark Strong - PC Mike Butterworth
- Ann Bell - Catherine Dawson
- Zoë Wanamaker - Emma Pickford
- Jonny Lee Miller - Student
- Rhondda Findleton - Anne Harding
- Geraldine James - Helen Field
- Elizabeth Hurley - Julia
- Fabia Drake - Mrs. Jarman
- John Bluthal - Victor Ignotas
- Janet Suzman - Dr. Claire Brewster
- Keith Allen - John Peter Barrie
- Richard Pasco - William Bryce-Morgan
- Andrew Ray - Alfred Rydale
- Phil Davis - Roland Sherman
- Jason Isaacs - Dr. Desmond Collier
- Patsy Byrne - Mrs. Maltby
- Michael Aldridge - Arthur Drysdale
- Mildred Shay - Janet Roscoe
- Robert Stephens - Sir Wilfred Mulryne
- Michael Gough - Philip Ogleby
- Charlotte Mitchell - Mrs Staveley
- Peter Amory - DC Hilaire
- Tom Wilkinson - Jake Normington
- Paul Shelley - Stephen Radford
- David Lonsdale - Detective
- Iain Cuthbertson - Desmond McNutt
- Oliver Ford Davies - Frederick Redpath
- Maggie O'Neill - Hilary Dobson
- Carole Ashby - Laura
- Con O'Neill - Paul Matthews
- John Castle - Tony Doyle
- Philip Bretherton - David Acum
- Shirley Stelfox - Mrs. Kane
- Norman Jones - Chief Inspector Bell
- Jason Durr - John Brewster
- Kevin Stoney - Heironymous St John
- Adrian Dunbar - John Marriat
- Martin Clunes - James Balcombe
- Jim Broadbent - Charlie Bennett
- Isla Blair - Janey Wilson
- Clifford Rose - Dr. Charles Hudson
- Laura Sadler - Sabena
- Gary Webster - Colin
- Bryan Pringle - Barker
- Geoffrey Palmer - Matthew Copley-Barnes
- Lionel Jeffries - Charles Radford
- Jenny Howe - Angry Neighbour
- Pat Heywood - Mrs. Mitchell
- James Hazeldine - Digby Tuckerman
- Jeremy Clyde - Roger McMill
- Glyn Houston - George Craven
- Christine Kavanagh - Lucy Downes
- Ian McNeice - Pathologist
- Cheryl Hall - Laura - Secretary
- John Elmes - Roger Meadows
- Maurice O'Connell - Harry Josephs
- Robert Lang - Chief Superintendent Dewar
- Roger Lloyd Pack - Donald Martin
- Norman Rodway - Roland Marshall
- David Ryall - Derek Whittaker
- Christopher Eccleston - Terrence Mitchell
- Tilly Vosburgh - Irene Saunders
- James Faulkner - Basilios Vasilakis
- Nicola Cowper - Jane Marriot
- John Gielgud - Lord Hinksey
- Richard Griffiths - Canon Humphrey Appleton
- Joanna David - Susan Fallon
- Gwen Taylor - Margaret Cliff
- Sean Bean - Alex Bailey
- Liza Walker - Vicky Wilson
- Bev Willis - Denman
- Connor Byrne - Constable Willis
- Charles Collingwood - Cassidy
- Michael Attwell - Parsons
- Noel Johnson - Butler
- Richard Pearson - Jerome Hogg
- Freddie Jones - Harry Field Senior
- Holly Aird - Angie Hartman
- Robert Hardy - Andrew Baydon
- Gilly Coman - Holly Trevors
- Harriet Walter - Dr. Esther Martin
- Alun Armstrong - Superintendent Holdsby
- James Aubrey - Pathologist
- Sorcha Cusack - Joyce Garrett
- Michael Bertenshaw - Detective
- Bert Parnaby - Ben
- Patrick Troughton - George Jackson
- Richard Owens - Dr. Mathew Brewster
- Denys Hawthorne - Chief Superintendent Rennie
- John Bird - George Linacre
- Shahnaz Pakravan - Doctor
- Maurice Denham - Lance Mandeville
- Martin Jarvis - Randall Rees
- Ronald Pickup - Ian Matthews
- Jenny Jay - Sylvia Kane
- Carol Starks - Jane Folley
- Brian Bovell - Pierre
- Ralph Nossek - Professor Joshua Masterson
- Jonathan Firth - Peter Thornton
- Charlotte Chatton - Marilyn Garrett
- John Cater - The Dean
- Sian Thomas - Carol Sharp
- Antony Carrick - George Granger
- Nathaniel Parker - Jamie Jasper
- David Neal - Dr. Julian Dear
- Jenny Laird - Mrs. Keelan
- Ben Onwukwe - Doctor
- Terrence Hardiman - Clive Palmer
- John Bett - Thomas Neely
- Don Fellows - Lyman Stansky
- Jamie Foreman - Chas
- Richard Wilson - Brian Thornton
- Gemma Jones - Anne Staveley
- Anna Patrick - Eirl's Secretary
- Geoffrey Beevers - Peter Foster
- Jean Ainslie - Cleaning Lady
- Jan Harvey - Friday Rees
- Jill Baker - Jennifer Coleby
- Julian Curry - Alan Cartwright
- Anna Massey - Lady Emily Balcombe
- Preston Lockwood - College Chaplain
- Richard Cubison - Pharmacist
- Vania Vilers - Paul Eirl
- Rosalind March - Susie Tuckerman
- Doug Bradley - Clergyman Williams
- Steven Mackintosh - DS Cheetham
- Souad Faress - Hospital Doctor
- Trevor Byfield - Harry Field
- Diana Quick - Hilary Stephens
- Billy Hartman - Police Sergeant
- Sue Johnston - Mrs. Bailey
- Allan Corduner - Gentile Bellocchio
- Joan Blackham - Helen Buscott
- Tony Steedman - Lawrence Cryer
- Andrew Read - Peter Morris
- Gina McKee - Girl in Betting Shop
- Jill Johnson - Mrs. Burns
- Alan David - Sir Watkin Davies
- Robert Arden - Eddie Poindexter
- Pamela Stirling - French Woman
- Paul Mooney - Pathologist
- Christopher Hunter - Andreas Heller
- Philip Anthony - Newspaper Editor
- Frederick Treves - Dean of Lonsdale College
- Simon Callow - Theodore Kemp
- Andrew Wilde - Edward Manley
- Mel Martin - Rosemary Henderson
- Pearce Quigley - Mick McGovern
- Kim Thomson - Helen Radford
- Tariq Yunus - George
- Tessa Wojtczak - Angie Howe
- Christopher Fulford - Tim Ablett
- John Jarratt - Sergeant Scott Humphries
- Jonathan Coy - Harry Balcombe
- Julia Goodman - May Lawrence
- Kate Harper - Patti Wilcox
- Patrick Drury - Frank McTeer
- Isabel Dean - Isobel Radford
- Andy Bradford - Trevor Radford
- John Junkin - Chief Inspector Holroyd
- Ted Childs
- Chris Burt
- David Lascelles
- John Thaw
- Ray Frift
- Deirdre Keir
Noah Taylor interpreta a Dave Harding en la serie.
Sean Bean interpreta a Alex Bailey en la serie.
Alun Armstrong interpreta a Superintendent Holdsby en la serie.
Jim Broadbent interpreta a Charlie Bennett en la serie.
Paul Freeman interpreta a Frank Harrison en la serie.
Nicky Henson hace el papel de Vince Cranston.
Don Fellows hace el papel de Lyman Stansky.
Simon Callow interpreta a Theodore Kemp en la serie.
Mark Strong hace el papel de PC Mike Butterworth.
John Thaw interpreta a Chief Inspector Morse en la serie.
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