- Eric Adams - Self - New York City Mayor
- Eric Holder - Self - Former US Attorney General
- Bernie Sanders - Self - Senator
- Adam Schiff - Self - Representative
- Gavin Newsom - Self - Governor of California
- Catherine Cortez Masto - Self - Senator
- Jordan Klepper - Self
- John Kerry - Self - Special Presidential Envoy for Climate
- Alexandria Ocasio-Cortez - Self - Representative
- Ron Klain - Self - Former White House Chief of Staff
- Neal Katyal - Self - Former U.S. Acting Solicitor General
- Jamie Raskin - Self - Representative
- Colin Allred - Self - Representative
- Katie Porter - Self - Representative
- Alexis McGill Johnson - Self - Planned Parenthood President and CEO
- Cory Booker - Self - Senator
- John Leguizamo - Self
- Chris Murphy - Self - Senator
- James Comey - Self - Former FBI Director
- David Plouffe - Self - Former Obama Campaign Manager
- Gisele Fetterman - Self
- John O. Brennan - Self - Former CIA Director
- Ben Rhodes - Self - Former Deputy National Security Advisor
- Jim Himes - Self - Representative
- Elise Stefanik - Self (archive footage)
- Marjorie Taylor Greene - Self (archive footage)
Jen Psaki interpreta a Self - Host en la serie.
Capítulo disponible en las siguientes plataformas:
