- Luke Pasqualino - Lee
- Ophelia Lovibond - Rachel
- Julian Rhind-Tutt - Mark
- Anna Chancellor - Elizabeth
- Marc Wootton - John
- Ben Willbond - Jeremy
- Timothy West - Andrew
- Denis Lawson - Gerald
- Oona Chaplin - Sabrina
- Joyce Veheary - Kim
- Kayvan Novak - Paul
- Gemma Arterton - Gerri
- Conleth Hill - Stevie
- Sophie Thompson - Jan
- Lucy Hutchinson - Tamsin
- David Bedella - Frankie J Parsons
- Tamsin Greig - Sally
- Adam Deacon - Si
- Roger Sloman - Bill
- Di Botcher - Jean
- Lyndsey Marshal - Laura
- Julia Davis - Felicity
- Richard Cordery - Nick
- Jo Stone-Fewings - Macduff (voice)
- Aimee-Ffion Edwards - Katy
- Helen McCrory - Tabitha
- Poppy Rush - Shell
- Sean Buckley - Andras
- Bruce Mackinnon - Malcolm (voice)
- Julie Hesmondhalgh - Kath
- Mark Benton - Les
- Jessica Gunning - Shona
- Jack Whitehall - Hugo
- Sheridan Smith - Christine
- Tom Riley - Adam
- Stacy Liu - Fung
- Michele Dotrice - Marion
- Jessica Ellerby - Zara
- Paul Copley - Ernie
- Joel Little - Jack
- Dexter Little - Jack
- David Warner - Sir Andrew Pike
- Sinead Matthews - Sarah Nutter
- Jim Howick - Thomas Nutter
- Trevor Cooper - George Waterhouse
- Paul Kaye - Richard Two-Shoes
- Ruth Sheen - Elizabeth Gadge
- Jane Horrocks - Liz
- Nikki Amuka-Bird - Joanne
- Tony Way - Michael
- Edward Easton - Caller
- Vilma Hollingbery - Caller
- Kath Hughes - Caller
- James Meehan - Caller
- Vicky Hall - Caller
- Christopher Whitlow - Paramedic
- Claire Skinner - Angela
- Eve Gordon - Katie
- Elsie Kelly - Maggie
- Lorraine Ashbourne - Carol
- Sophie McShera - Tina
- Alison Steadman - Anne
- Dan Starkey - Clive
- Cariad Lloyd - Gemma
- Alice Lowe - Amanda
- Miranda Hennessy - Hannah
- Jenna Coleman - Beattie
- Kadiff Kirwan - Sam
- Jill Halfpenny - Jennie
- Fionn Whitehead - Gabriel
- Tom Goodman-Hill - DI Hewson
- Olly Hudson-Croker - Connor
- Debbie Rush - Julia
- Gaby French - Mia
- Bobby Schofield - Patrick
- David Morrissey - Martin
- Steve Speirs - Mitch
- Ralf Little - Phil
- Dipo Ola - Calvin
- Sarah Solemani - Emily
- David Bamber - Robin
- Jaygann Ayeh - Fred
- Rory Kinnear - Prince Rico / Gus
- Bill Paterson - Mr. Green
- Marcia Warren - Alice
- Hattie Morahan - Amber
- Helen Monks - Colette
- Tanya Franks - Tracey
- Kevin Eldon - Vince
- Monica Dolan - May
- Nick Moran - Spike
- David Calder - Percy
- Emilia Fox - Natasha
- Rufus Jones - Charles
- Nicola Walker - Harriet
- Tom Mulheron - Levi
- Phoebe Sparrow - Jackie
- Kenneth Cranham - Rupert
- Noel Clarke - Gordon
- Zoë Wanamaker - Paula
- Fenella Woolgar - June
- Weruche Opia - Maz
- Katherine Parkinson - Self
- Katherine Parkinson - Rebecca
- Nigel Planer - Frank
- Tim Key - Ian
- Tim Key - Self
- Ellie White - Anya
- Anne Reid - Self
- Anne Reid - Geraldine
- Reece Shearsmith - Various
- Reece Shearsmith - Gerry
- Reece Shearsmith - S/PC Varney
- Reece Shearsmith - Laurence
- Reece Shearsmith - Alan Curtis
- Reece Shearsmith - Maurice
- Reece Shearsmith - Tommy
- Reece Shearsmith - Stranger
- Reece Shearsmith - Viktor
- Reece Shearsmith - Maxwell
- Reece Shearsmith - Tom
- Reece Shearsmith - Urban Bedford
- Reece Shearsmith - David
- Reece Shearsmith - Henry
- Reece Shearsmith - Hector
- Reece Shearsmith - Archie
- Reece Shearsmith - George
- Reece Shearsmith - Pat
- Reece Shearsmith - Jonah
- Reece Shearsmith - Aidan
- Reece Shearsmith - Maureen / Mr Jelly
- Reece Shearsmith - Jim
- Reece Shearsmith - Neville Griffin
- Reece Shearsmith - Barnabus
- Reece Shearsmith - Terry
- Reece Shearsmith - James
- Reece Shearsmith - Scaramouche, a Soldier
- Reece Shearsmith - Clive
- Reece Shearsmith - Simon Smethurst
- Reece Shearsmith - Doug
- Reece Shearsmith - Max
- Reece Shearsmith - Eric
- Reece Shearsmith - Brendan
- Reece Shearsmith - Damon
- Reece Shearsmith - Ray
- Reece Shearsmith - Drew
- Reece Shearsmith - Stu
- Reece Shearsmith - Nick
- Reece Shearsmith - Mr Warren
- Reece Shearsmith - Tyler
- Reece Shearsmith - Self
- Reece Shearsmith - Greg
- Reece Shearsmith - Brian
- Reece Shearsmith - Alex
- Reece Shearsmith - Ronnie
- Reece Shearsmith - Dominic
- Reece Shearsmith - Rudolph
- Steve Pemberton - Various
- Steve Pemberton - Felix
- Steve Pemberton - Kenneth
- Steve Pemberton - Spencer Maguire
- Steve Pemberton - Len
- Steve Pemberton - Willy Wando
- Steve Pemberton - Malcolm
- Steve Pemberton - The Doctor
- Steve Pemberton - Andy
- Steve Pemberton - Galen
- Steve Pemberton - Darren
- Steve Pemberton - Mr Blenkin
- Steve Pemberton - Dickie
- Steve Pemberton - Blake
- Steve Pemberton - Eddie
- Steve Pemberton - Trevor
- Steve Pemberton - Keith
- Steve Pemberton - Jorg
- Steve Pemberton - Peter
- Steve Pemberton - Kenny
- Steve Pemberton - Jim
- Steve Pemberton - Ezra
- Steve Pemberton - Stan
- Steve Pemberton - Robert
- Steve Pemberton - Tony
- Steve Pemberton - Hugo
- Steve Pemberton - Chris
- Steve Pemberton - Jason
- Steve Pemberton - Mick
- Steve Pemberton - Oggy
- Steve Pemberton - Nigel
- Steve Pemberton - Mr Edwards
- Steve Pemberton - Wilma
- Steve Pemberton - Migg
- Steve Pemberton - Adrian
- Steve Pemberton - David
- Steve Pemberton - PC Thompson
- Steve Pemberton - Mr Clarke
- Steve Pemberton - Giles
- Steve Pemberton - Roger
- Steve Pemberton - Graham
- Steve Pemberton - Attendant
- Steve Pemberton - Bobby
- Steve Pemberton - Self
- Steve Pemberton - DI Ellis
- Steve Pemberton - Carl
- Steve Pemberton - Bob
- Philip Glenister - Craig
- Callum Coates - Tim
- Phil Davis - Bill
- Maxine Peake - Nadia
- Sara Kestelman - Therapist
- Rebecca Callard - Controller (voice)
- Malik Ibheis - DC Dobson
- Lindsay Duncan - Loretta Lamb
- Kevin Bishop - Arlo, a Fool
- Gemma Whelan - Columbina, a Maid
- Rosie Cavaliero - Self
- Rosie Cavaliero - Kirstie
- Paterson Joseph - Pantalone, a Rogue
- Rosa Robson - Hortensia, his Daughter
- Dino Kelly - Mario, his Son
- Sian Clifford - Iris
- Charles Armstrong - Home Secretary
- Bhavna Limbachia - Jo
- Donna Preston - Bev
- Pauline McLynn - Oona
- Adrian Dunbar - Adrian
- Aaron Neil - Curt
- Derek Jacobi - Webster
- Bamshad Abedi-Amin - Actor
- Sarah Parish - Dawn
- Julian Glover - Ralph
- Jack Wolfe - Oliver
- Debra Gillett - Penny
- Diane Morgan - Donna
- Patrice Naiambana - Fisherman
- Elin Owen - Ceri
- Rosie Ekenna - Gwen
- Sophie Okonedo - Katrina
- Robin Weaver - Philippa
- Siobhan Redmond - Matilda
- Daniel Mays - Shane
- Daisy Haggard - Lara
- Jason Isaacs - Clifford
- Noah Valentine - Zach
- Jessica Hynes - Helen
- Simon Callow - Dick
- Shobna Gulati - Posy
- Annette Badland - Winnie
- Samantha Spiro - Sue
- Anita Dobson - Frances
- Phil Daniels - Reggie
- Sian Gibson - Self
- Sian Gibson - Leanne
- Claire Rushbrook - Vicky
- Mathew Horne - Edgar
- Frances Barber - Lesley
- Asim Chaudhry - Jai
- Lee Mack - Lee Mack
- Gemma Page - Margaret
- Jason Watkins - Self
- Jason Watkins - Kevin
- Mary Keegan - Enid
- Ronay Poole - Bella
- Saskia Wakefield - Catherine
- Nick Mohammed - Gavin
- Nick Mohammed - Self
- Sheila Reid - Mollie
- Siobhan Finneran - Edith
- Mark Bonnar - Raymond
- Susan Wokoma - Cleo
- Joel Fry - Finn
- Philippa Dunne - Elena
- Charlie Cooper - Mossy
- Matthew Kelly - Harold
- Ethan Joseph-Robert - Robbie
- Eleanor Kirby - Ellie
- Dorothy Atkinson - Sheila
- Vinette Robinson - Val
- Mark Gatiss - Callum
- Mark Gatiss - Self
- Adrian Scarborough - Larry
- Tyler Cameron - Police Officer
- Stephanie Booty - Police Officer
- Amanda Abbington - Self
- Amanda Abbington - Dana Beckman
- Katherine Kelly - Lynne
- Angus Wright - Dr Death/Dr Morton
- Maddie Evans - Amy
- Eddie Marsan - Nathaniel
- Natalie Dormer - Lillian
- Hayley Squires - Devonshire
- James Swanton - The Curse
- Robin Askwith - Self
- Alexandra Roach - Nina
- Emily Howlett - Self
- Emily Howlett - Janet
- Tamzin Outhwaite - Connie
- Sarah Hadland - Fran
- Javone Prince - Duane
- Rebekah Hinds - Chantel
- Keeley Hawes - Louise
- Danny Baker - DJ (voice)
- Mathew Baynton - Ted
- Morgana Robinson - Carrie
- Peter Kay - Neil
- Montserrat Lombard - Bea
- Fiona Shaw - Jean
- Felicity Kendal - Patricia
- Johnny Flynn - Elliot Quinn
- Muriel Gray - Reporter
- Mark Chapman - BBC Radio 5 Live (voice)
- Ioanna Kimbook - Angel
- Sandra Gayer - Diana
- Ron Cook - Wilf
- Steve Pemberton
- Reece Shearsmith
- Josh Cole
- Adam Tandy
- Steve Ryde
- Christian Henson
David Warner interpreta a Sir Andrew Pike en la serie.
Sophie Okonedo interpreta a Katrina en la serie.
Julia Davis interpreta a Felicity en la serie.
Daniel Mays interpreta a Shane en la serie.
Kayvan Novak interpreta a Paul en la serie.
Simon Callow interpreta a Dick en la serie.
Derek Jacobi interpreta a Webster en la serie.
Nick Moran hace el papel de Spike.
Julian Glover hace el papel de Ralph.
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