- Ivanno Jeremiah - Max
- Ruth Bradley - DI Karen Voss
- Billy Jenkins - Seraph / Sam
- Carrie-Anne Moss - Dr. Athena Morrow
- Ukweli Roach - Anatole
- William Hurt - Dr. George Millican
- Dino Fetscher - Stanley
- Sonya Cassidy - Hester
- Mark Bonnar - Neil
- Marshall Allman - Milo Khoury
- Holly Earl - Agnes
- Will Tudor - V / Odi
- Jill Halfpenny - Jill Drummond
- Jack Derges - Simon
- Danny Webb - Hobb
- Manpreet Bachu - Harun Khan
- Sope Dirisu - Fred
- Rebecca Front - Vera
- Dan Tetsell - Salesman
- Philip Arditti - Salim Sadik
- Ellen Thomas - Lindsey Kiwanuka
- Claire Lams - Shop Assistant
- Caroline Lee-Johnson - Brothel Madame
- Akie Kotabe - Dr. Ji Dae-Sun
- Krishnan Guru-Murthy - Himself
- Jonathan Aris - Robert
- Tor Clark - Senior Technician
- Mark Flitton - Clark
- Paul Kaye - Silas Capek
- Tom Bell - School Synth
- Beverly Hills - Head Teacher
- Steven Pacey - Colin (Client)
- Dominic Mafham - Chief Superintendent Shaw
- Naoko Mori - Fiona
- Adam Astill - Journalist
- Alana Boden - Caroline
- Joshua Hill - Cyclist
- Emma Davies - Mrs. Kennedy
- Tom Brittney - Greg
- Matthew Tennyson - Howard
- Daisy Keeping - Nelly
- Joshua Johnson - Danny
- James Backway - Kyle
- Eva Jane Willis - Girl in Café
- Grace Chilton - Persona Technician
- Danny Babington - Smash Club Man
- Nigel Boyle - Rickie
- John Ramm - Malcolm
- Neil McKinven - Taxi Driver
- Mark Weinman - Persona Driver
- Stella Gonet - Frances Walker
- Adam Newington - Police Synth
- Ashley Zhangazha - Speaker
- Jonathan Harden - Andy
- Adam Leese - Dad in Playground
- Dani Biernat - Nurse
- Laurence Ubong Williams - Police Officer
- Joss Porter - Policeman
- Angela Clerkin - Teacher
- Ann Akinjirin - Police Woman
- Jamie Michie - Constable
- Duncan Pow - Scientist
- Andrea Hart - Protest Leader
- Christopher Patrick Nolan - Protester
- Michael Dixon - Sentry Constable
- Raphael Acloque - Ten
- Lauren Carse - Rowan
- Josie Lawrence - Barbara
- Claudia Harrison - Dr. Aveling
- Anthony Flanagan - Jansen
- Callum Adams - Engineer
- Chloë Wicks - V (voice)
- Sam Woolf - Artie
- Tom Morley - Lab Synth
- Eric Kofi Abrefa - Danny
- Anastasia Hille - Diane
- Teresa Churcher - Bank Worker
- Mark Roper - Recycling Centre Employee
- Letitia Wright - Renie
- William Andrews - Scientist I
- Aidan McArdle - Peter Keeley
- Ian Burfield - Gavin
- Nathalie Armin - Tabitha
- Cosmo Jarvis - Martin
- Finlay Robertson - Dr. Rose
- Alex Waldmann - Care Home Worker
- Anna Skellern - Emma Harris
- Justin Salinger - Connor
- Oliver Bodur - Arvinder
- Paul Keating - Priest
- James Greene - Elderly Man
- Gerald Kyd - Matthew
- Tim Ahern - Gil
- Susannah Doyle - Claudia Nowak
- Ritu Arya - Flash
- Alison Dowling - Flo
- Glenn Carter - Ziggy
- Robin McCallum - Headteacher
- Rob Witcomb - Mr. Saunders
- Greg Austin - Roland
- Liam Ainsworth - Young Man
- James Sutton - Repair Bay SCO19 Officer
- Richard Sutton - SCO19 Lead Officer
- Rachel Atkins - Angry Woman
- Jack Shalloo - Estate Agent
- Paul Sockett - Reporter
- Lizzie Roper - Mary
- Sam Cassidy - Orange Eyes
- Bella Dayne - Astrid
- Thusitha Jayasundera - Neha Patel QC
- Sam Palladio - Ed
- Will Payne - Ferdinand
- Gregory Floy - Bishop
- Oliver Coopersmith - Laurence
- Sion Tudor Owen - Jez
- Staz Nair - Gordon
- Naveed Khan - Imam
- Matthew Marsh - Lord Dryden
- Phil Dunster - Tristan
- Neil D'Souza - Steve Covell
- Peter Barrett - Police Guard
- Richard Gadd - Protester
- Paul Reynolds - Father At Stall
- Simon Harrison - Dr. Sanchez
- Andrew Neil - Elderly Man
- Jonathon Michaels - Uniformed Police Officer (uncredited)
- Andrea Hall - PC Martine Franks
- Stephen Boxer - Dr. David Elster
- Francis Magee - Tex
- Glyn Harper
- Jack Wren
- Charlotte Rutherford
- Lars Lundström
- Victor Jenkins
- Kate Denning
- Vicki Delow
- Sam Vincent
- Chris Sheriff
- Emma Kingsman-Lloyd
- Grant Bridgeman
- Cristóbal Tapia de Veer
- Richard Davey
- Sarah Howe
- Laura Clough
- Ben Brazier
Carrie-Anne Moss interpreta a Dr. Athena Morrow en la serie.
Teresa Churcher interpreta a Bank Worker en la serie.
William Hurt interpreta a Dr. George Millican en la serie.
Katherine Parkinson hace el papel de Laura Hawkins.
Gemma Chan interpreta a Anita / Mia en la serie.
Emily Berrington interpreta a Niska en la serie.
Lucy Carless interpreta a Mattie Hawkins en la serie.
Colin Morgan interpreta a Leo Elster en la serie.
Theo Stevenson interpreta a Toby Hawkins en la serie.
Pixie Davies hace el papel de Sophie Hawkins.
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