- Tracy Morgan - The Invisible Man (voice)
- Fred Armisen - Dr. Marker
- Casey Wilson - Young Mom
- Linda Cardellini - Melody Richards
- Kristen Schaal - Girl in Doritos Commercial
- David Cross - Peter Burns
- A.D. Miles - CrimeTime Reenactor
- Andy Samberg - Jonathan
- Patton Oswalt - Let's Go Fan
- Atticus Shaffer - Wade Richards (uncredited)
- Ghostface Killah - Self
- Mary Lynn Rajskub - Mindy
- Paul Iacono - Billy Boy
- Bill Hader - Little Kevin
- Nick Swardson - Rob's Agent
- Alison Becker - Emergency Dating Service Girl
- Jonah Hill - Weenie King Customer
- Michael Delaney - NYU Professor
- Andy Blitz - Tony Woliner
- Andy Blitz - Osama Bin Diesel
- Jay Johnston - Whale Trainer
- Nichole Hiltz - Tina
- Jackie Clarke - Shelia
- Rob Riggle - Barry
- Rob Riggle - Neil Daly
- Adam Farabee - Reggie
- Kristen Ruhlin - Lemonade Girl
- Anthony Del Negro - Jack / Lemonade Boy (uncredited)
- Matt Walsh - Sugar Plums Agent
- Matt Walsh - Sugarplums Agent / Illusionators Volunteer
- Matt Walsh - Angry Bruce Willis Fan
- Jon Glaser - Devil
- Jon Glaser - Ernie Glaser
- Will Blagrove - Streetballer
- David Foy - Austin Powers Impersonator
- Alexandra Gizela - News Reporter
- June Diane Raphael - Casting Director
- June Diane Raphael - Wife
- Susan Lay - Miriam
- Angela Muto - Crack Head
- Brian Posehn - Various
- Brian Posehn - Brian
- Brian Posehn - Wade Miller
- H. Jon Benjamin - Jeff Donovan
- H. Jon Benjamin - Hard_abs05 / Detective Keith Malloy
- Miriam Tolan - Susan
- Girstin Bergquist - Waitress / Party Guest (uncredited)
- Brandon Johnson - CrimeTime Reenactor
- Aziz Ansari
- Paul Scheer
- Rob Huebel
Linda Cardellini interpreta a Melody Richards en la serie.
Aziz Ansari interpreta a Aziz / Various en la serie.
Paul Scheer interpreta a Paul / Various en la serie.
Rob Huebel hace el papel de Rob / Various.
David Cross interpreta a Peter Burns en la serie.
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