- Patricia Clarkson - Pam-I-Am (voice)
- Jillian Bell - Gluntz / Hayzel (voice)
- Jeffrey Wright - McWinkle (voice)
- Kevin Michael Richardson - Gobo / Robababobrian (voice)
- James Marsden - Bo (voice)
- Lombardo Boyar - Guard / Zook Guard 2 / Patrol Zook 2 (voice)
- Lombardo Boyar - Patrol Zook / Fresco Dooka (voice)
- Lombardo Boyar - Lab Assistant / Patrol Zook (voice)
- Lombardo Boyar - Zook Soldier 1 / Zook Guard (voice)
- Lombardo Boyar - Yook Guard / Guard 1 / Guard 4 (voice)
- Herbert Siguenza - Zook Soldier 2 / Zook Guard / TV Announcer (voice)
- Herbert Siguenza - Guard 2 / Guard 3 / Guard 5 (voice)
- Herbert Siguenza - Zook Guard 1 / Zook Guard 3 / Patrol Zook 1 (voice)
- Herbert Siguenza - Patrol Yook (voice)
- Gloria Calderón Kellett - Guide / Fresco Dookess / Doctor (voice)
- Gloria Calderón Kellett - Smooth Female Voice (voice)
- Rob Brydon - Philip Trousers / Snalfred (voice)
- Gwendoline Christie - Marilyn Blouse (voice)
- Darren Criss - Looka (voice)
- Marques Ray - Guy Watcher (voice)
- Nika Futterman - Crony 2 (voice)
- Nika Futterman - Snotty Woman (voice)
- Nika Futterman - Tinytopian Girl (voice)
- Nika Futterman - Happy Kid (voice)
- Nika Futterman - Receptionist (voice)
- Nika Futterman - Merchant (voice)
- Nika Futterman - Waitress (voice)
- Nika Futterman - Carol / Tiny Ancient Woman (voice)
- Chris Diamantopoulos - Bean Counter (voice)
- Dee Bradley Baker - Chickeraffe (voice)
- Dee Bradley Baker - Dolphacuda (voice)
- Dee Bradley Baker - Camelope (voice)
- Joe Hanna - Chef (voice)
- Jeff Bennett - Tinytopian 1 / Patrol Zook (voice)
- Jeff Bennett - Ma Snerz (voice)
- Jeannie Elias - Mrs. McGrisses (voice)
- Jeannie Elias - Proprietress (voice)
- Kari Wahlgren - Inventor #3 (voice)
- Kari Wahlgren - Female Passerby 2 (voice)
- Kari Wahlgren - Do-Gooder (voice)
- Kari Wahlgren - Fa Ma (voice)
- Kari Wahlgren - Kid Ant (voice)
- Fred Tatasciore - Yes Man (voice)
- Fred Tatasciore - Schvizelton Neighbor 3 (voice)
- Fred Tatasciore - Proprietor 6 (voice)
- Fred Tatasciore - Grandpa (voice)
- Fred Tatasciore - Pokie-McDokie Man / Cabbie Right (voice)
- Fred Tatasciore - Flea (voice)
- Fred Tatasciore - Boss (voice)
- Fred Tatasciore - Townsperson 1 (voice)
- Fred Tatasciore - Glurfsberg Cop 2 (voice)
- Fred Tatasciore - Jeremy (voice)
- Fred Tatasciore - Patrol Zook / Thrasher (voice)
- Fred Tatasciore - Zook Goon 1 (voice)
- Fred Tatasciore - Emergency Worker 3 (voice)
- Tracy Morgan - Fox (voice)
- Keith Ferguson - Crony 3 (voice)
- Keith Ferguson - Patron 1 (voice)
- Keith Ferguson - Guard 1 / Hat Man (voice)
- Keith Ferguson - Additional Biker 2 (voice)
- Keith Ferguson - Zook Goon 2 (voice)
- Keith Ferguson - News Anchor (voice)
- Keith Ferguson - Executive (voice)
- Keith Ferguson - Inventor #2 (voice)
- Keith Ferguson - Bus Announcer (voice)
- Keith Ferguson - Confused Employee (voice)
- Keith Ferguson - Carnie (voice)
- Brad Abrell - Shvizelton Cop 1 (voice)
- Brad Abrell - Dad (voice)
- Brad Abrell - Fun Fam Dad (voice)
- Brad Abrell - Passerby 3 (voice)
- Brad Abrell - Zoo Guard (voice)
- David Kaye - Father (voice)
- David Kaye - Announcer (voice)
- David Kaye - Yook 2 (voice)
- David Kaye - Guard 2 (voice)
- David Kaye - Joaquin Furmano / Smoothie Salesman / Cabbie Left (voice)
- David Kaye - Zook Guard / Joaquin Furmano (voice)
- David Kaye - Dad Fish/Crony 1 (voice)
- David Kaye - Grizzled Patrol Zook (voice)
- David Kaye - Patrol Zook 2 (voice)
- David Kaye - Conductor (voice)
- David Kaye - Joaquin Furmano (voice)
- David Kaye - Taxi Driver (voice)
- David Kaye - PA Announcer (voice)
- David Kaye - Executive (voice)
- Hynden Walch - Happy Kid 2 (voice)
- Hynden Walch - Inventor #1 (voice)
- Hynden Walch - Diabolical Shackle (voice)
- Hynden Walch - Family Kid (voice)
- Hynden Walch - One Fish (voice)
- Hynden Walch - Can Opener (voice)
- Hynden Walch - Patron 2 (voice)
- Daveed Diggs - Mouse (voice)
- Stephanie Courtney - Loretta Mums (voice)
- Stephanie Courtney - TSA Agent (voice)
- Stephanie Courtney - Farmer's Wife (voice)
- Rob Paulsen - Little Snerz (voice)
- Rob Paulsen - Pool Shark (voice)
- Bob Joles - Pig (voice)
- Bob Joles - Passerby 1 (voice)
- Bob Joles - Walter (voice)
- Bob Joles - Snerzco Employee (voice)
- Bob Joles - Guard 1 (voice)
- Bob Joles - Shvizelton Cop 2 (voice)
- Grey DeLisle - Z Magazine Reporter (voice)
- Grey DeLisle - Waitress (voice)
- Grey DeLisle - Ty (voice)
- Stephen Tobolowsky - Chad (voice)
- David Pressman - Announcer (voice)
- David Pressman - Laundry Guard (voice)
- David Pressman - Stockholder 2 (voice)
- Jill Talley - Mother (voice)
- Jill Talley - School Valedictorian (voice)
- Jill Talley - Stockholder 3 (voice)
- Billy Eichner - Bigman (voice)
- John Turturro - Goat (voice)
- Nora Zehetner - Clerk (voice)
- José Andrés Puerta - Sylvester (voice)
- Dr. Seuss
- Ellen DeGeneres
- David Dobkin
- Sam Register
- David Newman
- Yola
Stephen Tobolowsky interpreta a Chad (voice) en la serie.
Eddie Izzard interpreta a Snerz (voice) en la serie.
Jeffrey Wright interpreta a McWinkle (voice) en la serie.
Hector Elizondo hace el papel de Dooka (voice).
John Turturro interpreta a Goat (voice) en la serie.
Adam Devine hace el papel de Sam-I-Am (voice).
Michael Douglas interpreta a Guy-Am-I (voice) en la serie.
Ilana Glazer interpreta a Eb (voice) en la serie.
Diane Keaton hace el papel de Michellee (voice).
Keegan-Michael Key interpreta a Narrator (voice) en la serie.
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