- Patricia Clarkson - Pam-I-Am (voice)
- Jillian Bell - Gluntz / Hayzel (voice)
- Jeffrey Wright - McWinkle (voice)
- Kevin Michael Richardson - Gobo / Robababobrian (voice)
- James Marsden - Bo (voice)
- Lombardo Boyar - Guard / Zook Guard 2 / Patrol Zook 2 (voice)
- Lombardo Boyar - Patrol Zook / Fresco Dooka (voice)
- Lombardo Boyar - Lab Assistant / Patrol Zook (voice)
- Lombardo Boyar - Zook Soldier 1 / Zook Guard (voice)
- Lombardo Boyar - Yook Guard / Guard 1 / Guard 4 (voice)
- Herbert Siguenza - Zook Soldier 2 / Zook Guard / TV Announcer (voice)
- Herbert Siguenza - Guard 2 / Guard 3 / Guard 5 (voice)
- Herbert Siguenza - Zook Guard 1 / Zook Guard 3 / Patrol Zook 1 (voice)
- Herbert Siguenza - Patrol Yook (voice)
- Gloria Calderón Kellett - Guide / Fresco Dookess / Doctor (voice)
- Gloria Calderón Kellett - Smooth Female Voice (voice)
- Rob Brydon - Philip Trousers / Snalfred (voice)
- Gwendoline Christie - Marilyn Blouse (voice)
- Darren Criss - Looka (voice)
- Marques Ray - Guy Watcher (voice)
- Nika Futterman - Crony 2 (voice)
- Nika Futterman - Snotty Woman (voice)
- Nika Futterman - Tinytopian Girl (voice)
- Nika Futterman - Happy Kid (voice)
- Nika Futterman - Receptionist (voice)
- Nika Futterman - Merchant (voice)
- Nika Futterman - Waitress (voice)
- Nika Futterman - Carol / Tiny Ancient Woman (voice)
- Chris Diamantopoulos - Bean Counter (voice)
- Dee Bradley Baker - Chickeraffe (voice)
- Dee Bradley Baker - Dolphacuda (voice)
- Dee Bradley Baker - Camelope (voice)
- Joe Hanna - Chef (voice)
- Jeff Bennett - Tinytopian 1 / Patrol Zook (voice)
- Jeff Bennett - Ma Snerz (voice)
- Jeannie Elias - Mrs. McGrisses (voice)
- Jeannie Elias - Proprietress (voice)
- Kari Wahlgren - Inventor #3 (voice)
- Kari Wahlgren - Female Passerby 2 (voice)
- Kari Wahlgren - Do-Gooder (voice)
- Kari Wahlgren - Fa Ma (voice)
- Kari Wahlgren - Kid Ant (voice)
- Fred Tatasciore - Yes Man (voice)
- Fred Tatasciore - Schvizelton Neighbor 3 (voice)
- Fred Tatasciore - Proprietor 6 (voice)
- Fred Tatasciore - Grandpa (voice)
- Fred Tatasciore - Pokie-McDokie Man / Cabbie Right (voice)
- Fred Tatasciore - Flea (voice)
- Fred Tatasciore - Boss (voice)
- Fred Tatasciore - Townsperson 1 (voice)
- Fred Tatasciore - Glurfsberg Cop 2 (voice)
- Fred Tatasciore - Jeremy (voice)
- Fred Tatasciore - Patrol Zook / Thrasher (voice)
- Fred Tatasciore - Zook Goon 1 (voice)
- Fred Tatasciore - Emergency Worker 3 (voice)
- Tracy Morgan - Fox (voice)
- Keith Ferguson - Crony 3 (voice)
- Keith Ferguson - Patron 1 (voice)
- Keith Ferguson - Guard 1 / Hat Man (voice)
- Keith Ferguson - Additional Biker 2 (voice)
- Keith Ferguson - Zook Goon 2 (voice)
- Keith Ferguson - News Anchor (voice)
- Keith Ferguson - Executive (voice)
- Keith Ferguson - Inventor #2 (voice)
- Keith Ferguson - Bus Announcer (voice)
- Keith Ferguson - Confused Employee (voice)
- Keith Ferguson - Carnie (voice)
- Brad Abrell - Shvizelton Cop 1 (voice)
- Brad Abrell - Dad (voice)
- Brad Abrell - Fun Fam Dad (voice)
- Brad Abrell - Passerby 3 (voice)
- Brad Abrell - Zoo Guard (voice)
- David Kaye - Father (voice)
- David Kaye - Announcer (voice)
- David Kaye - Yook 2 (voice)
- David Kaye - Guard 2 (voice)
- David Kaye - Joaquin Furmano / Smoothie Salesman / Cabbie Left (voice)
- David Kaye - Zook Guard / Joaquin Furmano (voice)
- David Kaye - Dad Fish/Crony 1 (voice)
- David Kaye - Grizzled Patrol Zook (voice)
- David Kaye - Patrol Zook 2 (voice)
- David Kaye - Conductor (voice)
- David Kaye - Joaquin Furmano (voice)
- David Kaye - Taxi Driver (voice)
- David Kaye - PA Announcer (voice)
- David Kaye - Executive (voice)
- Hynden Walch - Happy Kid 2 (voice)
- Hynden Walch - Inventor #1 (voice)
- Hynden Walch - Diabolical Shackle (voice)
- Hynden Walch - Family Kid (voice)
- Hynden Walch - One Fish (voice)
- Hynden Walch - Can Opener (voice)
- Hynden Walch - Patron 2 (voice)
- Daveed Diggs - Mouse (voice)
- Stephanie Courtney - Loretta Mums (voice)
- Stephanie Courtney - TSA Agent (voice)
- Stephanie Courtney - Farmer's Wife (voice)
- Rob Paulsen - Little Snerz (voice)
- Rob Paulsen - Pool Shark (voice)
- Bob Joles - Pig (voice)
- Bob Joles - Passerby 1 (voice)
- Bob Joles - Walter (voice)
- Bob Joles - Snerzco Employee (voice)
- Bob Joles - Guard 1 (voice)
- Bob Joles - Shvizelton Cop 2 (voice)
- Grey DeLisle - Z Magazine Reporter (voice)
- Grey DeLisle - Waitress (voice)
- Grey DeLisle - Ty (voice)
- Stephen Tobolowsky - Chad (voice)
- David Pressman - Announcer (voice)
- David Pressman - Laundry Guard (voice)
- David Pressman - Stockholder 2 (voice)
- Jill Talley - Mother (voice)
- Jill Talley - School Valedictorian (voice)
- Jill Talley - Stockholder 3 (voice)
- Billy Eichner - Bigman (voice)
- John Turturro - Goat (voice)
- Nora Zehetner - Clerk (voice)
- José Andrés Puerta - Sylvester (voice)
- Dr. Seuss
- Ellen DeGeneres
- David Dobkin
- Sam Register
- David Newman
- Yola
Stephen Tobolowsky interpreta a Chad (voice) en la serie.
Eddie Izzard interpreta a Snerz (voice) en la serie.
Jeffrey Wright hace el papel de McWinkle (voice).
Hector Elizondo hace el papel de Dooka (voice).
John Turturro hace el papel de Goat (voice).
Adam Devine interpreta a Sam-I-Am (voice) en la serie.
Michael Douglas interpreta a Guy-Am-I (voice) en la serie.
Ilana Glazer interpreta a Eb (voice) en la serie.
Diane Keaton interpreta a Michellee (voice) en la serie.
Keegan-Michael Key hace el papel de Narrator (voice).
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