- Tom Poston - Merle
- Cody Arens - Liam
- Zac Efron - Trevor
- Selena Gómez - Gwen
- Camilla Rosso - Janice Ellis
- Dante Basco - Hollywood London "Madrid"
- Mark Indelicato - Antonio
- William Schallert - David
- Chris Brown - Himself
- Raven-Symoné - Raven Baxter
- Becky Rosso - Jessica Ellis
- Sam McMurray - Bud
- Kiely Williams - Herself
- Eddie Mekka - Western Movie Director
- Jaden Smith - Travis
- Adrienne Bailon-Houghton - Herself
- Cheryl Burke - Shannon
- Benjamin Brown - Hollywood Moseby
- Tara Lynne Barr - Haley
- Kelsey Asbille - Dakota
- Sabrina Bryan - Herself
- Rich Correll - TV Director
- Giovonnie Samuels - Nia Moseby
- Cameron Goodman - Hollywood Maddie
- Michele Nordin - Hollywood Carey
- Nikki SooHoo - Western Movie Actress
- Jennifer Tisdale - Western Movie Actress
- Meaghan Jette Martin - Stacey
- Kaycee Stroh - Leslie
- Angela Shelton - Delilah
- Mark Povinelli - Bleep
- Danny Woodburn - Blop
- Dot-Marie Jones - Gretel
- Miley Cyrus - Miley Stewart / Hannah Montana
- Caroline Rhea - Ilsa Shickelgrubermeiger
- Ben Ziff - Todd St. Mark
- Nicole Sullivan - Miss Klotz
- Alicia Favela - Ella
- Vince Rimoldi - Tuck
- Bobby Mackey - Master Z
- Lewis Dauber - The Reverend
- Jascha Washington - Drew
- Daniel Booko - Kyle
- James Snyder - Jason Harrington
- Lyman Ward - George Harrington
- Victoria Justice - Rebecca
- Skyler Samuels - Brianna
- Matt Winston - Tim
- Brian McNamara - Serge
- Adam Grimes - Jeff
- Chad Broskey - Gavin
- Jody Howard - Claire
- Bru Muller - Troy Robbins
- Dennis Bendersky - Tapeworm
- Harrison Knight - Sheldon
- Parvesh Cheena - Mr. Babalabaloo
- Steve Hytner - Herman
- Troy Gentile - Jeremy
- Richard Gleason - Maurice
- Katelyn Pippy - Jolie
- Moisés Arias - Randall
- Logan Grove - Johnny
- Jim Jansen - Critic
- Michael D. Roberts - Henry
- Millicent Martin - Mrs. Delacourt
- Alyson Stoner - Max
- Joey King - Emily
- Dana Woods - Spencer Moseby
- Chris Dollard - Mr. Woodburn
- Lauren Cohn - Yolanda
- Max Burkholder - Billy
- Phil Abrams - Travis
- Kathryn Joosten - Marilyn
- Jake Abel - Kirk
- Scott Halberstadt - Dirk
- Don Stanton - Abner
- Aaron Parker Mouser - Maynard
- Vanessa Hudgens - Corrie
- Craig Ricci Shaynak - Irv Wheldon
- Eric Lutes - Harry O'Neil
- Sean Whalen - Whacky Wally
- Gage Golightly - Vanessa
- Allie Grant - Agnes
- Asante Jones - G-Man
- Monique Coleman - Mary Margaret
- David Shatraw - Harvey
- Alaina Reed Hall - Mrs. Mayweather
- Mindy Sterling - Sister Rose
- Rip Taylor - Leo
- Robert Torti - Kurt Martin
- Tahj Mowry - Brandon
- Gus Hoffman - Warren
- Carla Renata - Veronica
- David Blue - Dr. Chip
- Dan Levy - Jerry Barnes
- Alan Heitz - Mr. Fliegel
- Oliver Muirhead - Mr. Dwosh
- Nathan Kress - Jamie
- Daryl Mitchell - Daryl
- Denzel Whitaker - Trent
- Christopher Neiman - Lou
- Rik Young - Johnny Vaine
- Jason Brooks - Dakota Smith
- Chip Chinery - Pete
- Ernie Grunwald - Mr. Forgess
- Marianne Muellerleile - Sister Dominick
- Todd Tucker - Puppeteer
- Adam Cagley - Brick
- Mary Scheer - Mrs. Bird
- Alexa Nikolas - Tiffany
- Hannah Leigh - Amy
- Jareb Dauplaise - Wayne Wormser
- Adam Shapiro - Carl Pitz
- Samantha Hanratty - Holly O'Neil
- Raini Rodriguez - Betsy
- Cierra Ramirez - Jasmine
- Samantha Droke - Wanda
- Megan Hilty - Enid
- Mitchell Whitfield - Mr. Blaine
- Matt Angel - Vance
- Blythe Auffarth - Ellen
- Kathy Najimy - Ms. Millitich
- Kay Panabaker - Amber
- Charlie Stewart - Bob
- Patrick Bristow - Patrick
- Kara Taitz - Millicent
- Pat Finn - Sandy
- Kyle Gregory Sanderson - Billy
- Susan Blakely - Mrs. Madigan
- Adrian R'Mante - Esteban Ramírez
- Amanda Gallo - Abby
- Rolando Molina - Héctor
- Brittany Curran - Chelsea
- Tyler Steelman - Mark
- Rachel Thorp - Cassandra
- Justin Baldoni - Diego
- Booth Colman - Scooter
- Marcy Goldman - Mrs. Rittenhouse
- Sophie Oda - Barbara Brownstein
- Brian Stepanek - Arwin Hochauser
- Jerry Kernion - Chef Paolo
- Drew Seeley - Jeffrey
- Hunter Gomez - Rick
- Emma Stone - Ivana Tipton (voice)
- Estelle Harris - Muriel
- Daniella Monet - Dana
- Arturo Gil - Robot (voice)
- Sharon Jordan - Irene the Concierge
- Brian Peck - Mirror (voice)
- Valerie Ahern
- Danny Kallis
- Pamela Eells
- Jim Geoghan
- Walter Barnett
- Irene Dreayer
Marianne Muellerleile hace el papel de Sister Dominick.
Dylan Sprouse interpreta a Zack Martin en la serie.
Cole Sprouse interpreta a Cody Martin en la serie.
Ashley Tisdale interpreta a Maddie Fitzpatrick en la serie.
Brenda Song interpreta a London Tipton en la serie.
Kim Rhodes interpreta a Carey Martin en la serie.
Phill Lewis hace el papel de Marion Moseby.
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