- Emme Rylan - Lulu Spencer Falconeri
- James Patrick Stuart - Valentin Cassadine
- Scarlett Fernandez - Charlotte Cassadine
- Finola Hughes - Anna Devane
- Donnell Turner - Curtis Ashford
- Anthony Montgomery - Andre Maddox
- Rebecca Herbst - Elizabeth Webber
- Rebecca Herbst - Nurse Elizabeth Webber
- Rebecca Budig - Hayden Barnes
- Robert Palmer Watkins - Dillon Quartermaine
- Jane Elliott - Tracy Quartermaine
- Roger Howarth - Robert "Franco" Baldwin
- Roger Howarth - Franco Baldwin
- Chad Duell - Michael Corinthos
- Chad Duell - Michael [Quartermaine] Corinthos III
- Jon Lindstrom - Kevin Collins
- Dominic Zamprogna - Det. Dante Falconeri
- Dominic Zamprogna - Dante Falconeri
- Michelle Stafford - Nina Reeves Clay Lansing Cassadine
- Michelle Stafford - Nina Reeves Cassadine
- Carolyn Hennesy - Diane Miller
- Sonya Eddy - Epiphany Johnson
- Hayley Erin - Kiki Jerome
- Hayley Erin - Lauren Katherine "Kiki" Jerome
- Kin Shriner - Scott Baldwin
- Kin Shriner - Scotty Baldwin
- Jacklyn Zeman - Bobbie Spencer
- Vinessa Antoine - Police Commissioner Jordan Ashford
- Vinessa Antoine - Jordan Ashford
- Lexi Ainsworth - Kristina Corinthos-Davis
- Genie Francis - Laura Williams Vining Webber Baldwin Spencer
- Genie Francis - Laura Spencer
- Michael Easton - Dr. Hamilton Finn
- Michael Easton - Hamilton Finn
- Ryan Paevey - [James] Nathan West
- Ryan Paevey - Nathan West
- Kathleen Gati - Liesl Obrecht
- Marc Anthony Samuel - Felix DuBois
- Chloe Lanier - Janelle Benson / Nelle Hayes
- Chloe Lanier - Nelle Hayes
- Matt Cohen - Dr. Griffin Munro
- Matt Cohen - Griffin Munro
- Ryan Carnes - Lucas Jones
- John J. York - Mac Scorpio
- Leslie Charleson - Dr. Monica Bard Webber Quartermaine
- Leslie Charleson - Monica Quartermaine
- Wally Kurth - Edward "Ned" Lawrence Ashton Quartermaine
- Wally Kurth - Ned Ashton
- Lisa LoCicero - Olivia Falconeri Quartermaine
- Lisa LoCicero - Olivia Falconeri
- Kristina Wagner - Felicia Jones Scorpio
- Nathan Parsons - Ethan Lovett
- Risa Dorken - Nurse Amy Driscoll
- Risa Dorken - Amy Driscoll
- Jon Lindström - Kevin Collins
- Maurice Bernard - Sonny Corinthos
- Steve Burton - Jason Morgan
- Tamara Braun - Dr. Kim Nero
- Tamara Braun - Kimberly Nero
- Cynthia Watros - Nina Reeves
- Jonathan Jackson - Lucky Spencer
- Robin Christopher - Skye Quartermaine
- Robin Christopher - Skye Chandler
- Jacob Young - Lucky Spencer
- Greg Vaughan - Lucky Spencer
- Lindsey Pearlman - Margaret 'Maggie' McMorris
- Frank Maxwell - Dan Rooney
- Marcus Coloma - Nikolas Cassadine
- Nicholas Alexander Chavez - Spencer Casssadine
- Tyler Christopher - Nikolas Cassadine
- Stephen Martines - Nikolas Cassadine
- Evan Hofer - Dex Heller
- Kelly Monaco - Sam McCoy Morgan
- Kelly Monaco - Sam Morgan
- Kelly Monaco - Samantha Morgan
- Kelly Monaco - Sam McCall Morgan
- Kirsten Storms - Maxie Jones
- Kirsten Storms - Kristen Jones
- Haley Pullos - Molly Lansing-Davis
- Cade Brady McWatt - Cameron Spencer (as Cade McWatt)
- Linsay Rousseau - Pentonville Guard 1
- Aaron Bradshaw - Leo Falconeri
- Leah Caruana - Suffragist
- Joshua Benard - Young Sonny / Adam
- Robby Descant - Announcer
- James Hunter - Customer Ed
- Jonathan Stanley - Officer Billy Price
- Jonathan Stanley - Cop Billy
- Stuart Ambrose - Prison Guard (uncredited)
- Brandon Butler - Frat Guy #1
- Drew Moore - Trask
- Jason Thompson - Patrick Drake
- Bryan Craig - Morgan Corinthos
- Richard Burgi - Paul Hornsby
- Rick Hearst - Ric Lansing
- Alfred Adderly - Bailiff
- Angela Bullock - Judge Long
- Anthony Vitale - Aldo
Capítulo disponible en las siguientes plataformas:
