- Laurie Metcalf - Sarah
- Nina Arianda - Maggie
- Hannah Dunne - Jenny
- Reg E. Cathey - Harold
- Colin Quinn - Jimmy
- Conner O'Malley - Eric
- Nick Di Paolo - Nick
- John Sharian - Jerold
- Tom Noonan - Tom
- Colman Domingo - Dr. Evers
- Maria Dizzia - Tricia
- Lucy Taylor - Lucy
- Karen Pittman - Rhonda
- Mark Normand - Mark
- Dov Davidoff - Dom
- Craig muMs Grant - Ricardo
- Liza Treyger - Melissa
- Kyle Beltran - Charles
- Lynne Koplitz - Doris
- Greer Barnes - Carl
- Greer Barnes - Greer
- Jack O'Connell - Dennis
- Matthew Shear - Zach
- Angus T. Jones - Horace the 9th
- Amy Sedaris - Mara
- Burt Young - Horace Sr.
- Jack Gore - Young Horace
- Sofia Hublitz - Young Sylvia
- Nolan Lyons - Young Pete
- G. Keith Alexander - Announcer
- Peter Hans Benson - Accountant
- Zach Cherry - Young Hipster 1
- Tara Gadomski - Anchor Person
- Jonathan Hadary - Bearded Man
- Paul Laudiero - Young Hipster 2
- Charles Techman - Very Very Old Man
- Julio Torres - Young Hipster
- Stephen Wallem - Randall
- Ann Carr - Wanda
- Michelle Wolf - Margaret
- Michael Cyril Creighton - Mike
- Michael Cyril Creighton - Michael
- Bill de Blasio - Self
- Chris Carfizzi - Waiter
- Rick Shapiro - Rick
- Joanna Bradley - Joan
- Adam Feingold - Mover
- Marina Franklin - Marina
- Deborah Offner - Abby
- Hwalan Shub - Morgan
- George Wallace - George
- David Blaine - Magician at Bar (uncredited)
- Paul Simon - Leon's Friend (uncredited)
- Spike Einbinder - Hipster
- Dino Stamatopoulos
- Louis C.K.
- M. Blair Breard
- Dave Becky
- Kathy Welch
- Vernon Chatman
- Paul Simon
Louis C.K. interpreta a Horace en la serie.
Burt Young hace el papel de Horace Sr..
Steve Buscemi interpreta a Pete en la serie.
Edie Falco hace el papel de Sylvia.
Steven Wright hace el papel de Leon.
Kurt Metzger hace el papel de Kurt.
Alan Alda interpreta a Uncle Pete en la serie.
Jessica Lange hace el papel de Marsha.
Capítulo disponible en las siguientes plataformas:
