- Christopher Meloni - Billy
- Larry Poindexter - Jeffrey
- Burt Reynolds - Burt Reynolds
- JoNell Kennedy - Sheryl
- Patrick Labyorteaux - Howie
- Ilana Levine - Nina
- Greg Collins - Stripper
- Anthony Guidera - Pete
- Eric Allan Kramer - Isaac
- James Lesure - Delivery Man
- Steve Nevil - Steve
- DeeDee Rescher - Roma
- Marion Calvert - Mrs. Jonganti
- Joanna Sanchez - Esperanza
- Camille Saviola - Cookie
- Robin Florence - Bride
- Jennifer Aspen - Alexis
- Scott Bryce - Robert
- Jack Ong - Paul
- Paul Satterfield - J.T.
- Randy Harrington - Man
- Veanne Cox - Mary
- Gilbert Gottfried - Gilbert Gottfried
- Victoria Alexander - Victoria
- Victoria Alexander - Woman Stagehand
- Kim Alexis - Kim Alexis
- Bryan Clark - Pastor Earl
- Charles C. Stevenson Jr. - Dr. Leggett
- James Hampton - Bob
- Dorothy Lyman - Maxine
- Julie Newmar - Julie Newmar
- Adam West - Adam West
- James T. Callahan - Bill
- Kirk Cameron - Kirk Cameron
- Joanna Kerns - Joanna Kerns
- Michael McLafferty - Scott Koch
- Jeremy Miller - Jeremy Miller
- Taylor Negron - Gwillem
- Rachel Sweet - Sabine
- Keene Curtis - Dr. Green
- William Thomas, Jr. - Artie
- Billye Ree Wallace - Old Gloria
- Dorian Gregory - Dutch
- Miriam Flynn - Dr. Rose
- Lynne Marie Stewart - Margeurite
- Patience Cleveland - Old Hope
- Patience Cleveland - Grandma
- William R. Moses - Jeffrey
- José Eber - José Eber
- Danny Nero - Skip
- Danny Nero - Man
- Tim Bagley - Ed
- Melanie Graham - Patty
- Merv Griffin - Merv Griffin
- Julene Renee - Cynthia Parsons
- Jeff Conaway - Bud Green
- Deezer D - Orderly
- Lisa Howard - Lizbeth
- Jackie Swanson - Sister Theresa
- Swoosie Kurtz - Swoosie Kurtz
- Regis Philbin - Regis Philbin
- Julia Sweeney - Charity
- Wendy Schaal - Nurse Nancy
- Karen Hensel - Magda
- Ben Reed - Philip Kirwood
- Jean Kasem - Candy
- Shirley Prestia - Eleanore
- Alex Rocco - Bernie
- Mary Mara - Jennifer
- Ana Gasteyer - Girl
- Zoaunne LeRoy - Mrs. Jubadian
- William Ragsdale - Danny Saterfield
- Lisa Kudrow - Phoebe Buffay
- Joe Mantegna - Joe Mantegna
- Peter Reckell - Peter Reckell / Bo Brady
- Diane Behrens - Volunteer
- Nancy Cassaro - Simone
- Christopher Rich - Dr. Ben Shipley
- Ellen Albertini Dow - Miss Mae
- Joyce Brothers - Dr. Joyce Brothers
- William Devane - William Devane
- Grant Show - Grant Show
- Ian Ogilvy - David Kirkwood
- Michael Holden - Caterer
- Dawn Maxey - Caitlin
- Greg Coolidge - Dale
- Lisa Robin Kelly - Debbee
- Kevin Loreque - Young Pennsylvanian
- Kristen Miller - Young Pennsylvanian
- Chris Parnell - Howard
- Jack Plotnick - Seth
- John Allee - Young Pennsylvanian
- Brian McNamara - Dale Hutton
- Marianne Muellerleile - Meter Maid
- Stan Sellers - Scuba Diving Instructor
- Eddie Mekka - Eddie Mekka
- Cindy Williams - Connie Carlucci
- J. J. Paulsen
Marianne Muellerleile interpreta a Meter Maid en la serie.
Paul Satterfield hace el papel de J.T..
Joe Mantegna interpreta a Joe Mantegna en la serie.
Cynthia Stevenson hace el papel de Hope Davidson.
Jessica Lundy hace el papel de Gloria Utz.
Enrico Colantoni interpreta a Louis Utz en la serie.
Alan Thicke interpreta a Dennis Dupree en la serie.
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