- Jemma Redgrave - Bernie Wolfe
- Catherine Russell - Serena Campbell
- Joseph McFadden - Raffaello Di Lucca
- Nicola Stephenson - Julie Fitzjohn
- Dawn McDaniel - Kirstie Collins
- Luke Mably - Paul Ripley
- George Irving - Anton Meyer
- Angela Griffin - Jasmine Hopkins
- Clive Mantle - Mike Barratt
- Michael French - Nick Jordan
- Lisa Faulkner - Victoria Merrick
- Jeremy Edwards - Danny Shaughnessy
- David Paisley - Ben Saunders
- Simona Zivkovska - Carlie Ryland
- Simona Zivkovska - Kelly Belling
- Gerard Kelly - Jerry Campbell
- Madalena Alberto - Cristina Chapara
- Carli Norris - Fran Reynolds
- Camilla Arfwedson - Zosia March
- Camilla Arfwedson - Zosia Self
- Jack O'Connell - Davey Hunt
- Jana Carpenter - Vicky Slogan
- Jana Carpenter - Sheridan Talbot
- Joshua Bowman - Scott James
- James Hillier - Derek Humphries
- Eric Kole - André Hassan
- Lucy Phelps - Maria Timmins
- Steve Nicolson - Nicky Gardener
- Eileen O'Brien - Elizabeth Sagar
- Nicholas Hoult - Oscar Banks
- Ian Bonar - Rhys Gallagher
- Wim Snape - Tony Dunmore
- Judy Flynn - Meg West
- Orlando Wells - Guy Kilminster
- Brenock O'Connor - Angus Peters
- Louisa Clein - Kim Whitfield
- Marko Leht - Soloman Cazacu
- Andy Lucas - Michael Malone
- Clifford Samuel - Aiden Hammond
- Chris Coghill - Casimir Callahan
- Katy Reece - Caitlin Callahan
- Jack Hawkins - Alex Lambert
- Jeff Rawle - Jerry Clark
- Tessa Peake-Jones - Imelda Cousins
- Derek Thompson - Charlie Fairhead
- Bryan Murray - James Roberts
- Kevin Doyle - Simon Harwood
- Jonathan Kerrigan - Sam Colloby
- Claire Goose - Tina Seabrook
- Keeley Forsyth - Rachel Livingstone
- Danny Cunningham - Tom Woodley
- Lionel Jeffries - Harry
- Sean Maguire - Darren Ingram
- Gwen Taylor - Geraldine
- Paul Chequer - Neil Longford
- Carl Rice - Tommy
- Alex Lawther - Fred Bamber
- Jean Marsh - Vera Engells
- Jody Latham - Alan Bridger
- Sylvia Syms - Margaret Larkin
- Gregory Foreman - Louis Fairhead
- Jack Ryder - Sean Wells
- Josh Brown - Frankie Moore
- Joe Cole - Shaun Jackson
- Jonathan Readwin - Rory Loader
- Jonathan Readwin - Joel Duggan
- Robert Timmins - Toby Merrick
- Michael Jayston - Judge
- Siobhan Redmond - Janice Taylor
- Ryan Nelson - Jason Beatty
- Adam Paul Harvey - Scott Johnston
- Lewis McKenzie - Mark Wheatley
- McKell David - Lloyd Kramer
- McKell David - Callum Draper
- Sian Reeves - Rachel Harvey
- Cassidy Little - Jay Nevin
- Roland Curram - Ted Carver
- Russell Tovey - Jerome Hibbert
- Russell Tovey - Adam Spengler
- Seb Castang - Tim Wellmann
- Francesca Martinez - Molly Jarratt
- Andrew Neil - Fraser Connolly
- Senia Devine - Magda Kovalenko
- Tanya Burr - Joanne Pearsons
- Siubhan Harrison - Mica Khan
- Kate Braithwaite - Siobhan 'Shiv' Carter
- Kip Gamblin - Greg Fallon
- Rahul Kohli - Cal Nelson
- Philip Anthony - Bill Haines
- Lee Ryan - Adrian Kirkwall
- Barry Aird - Gary Turnball
- Eugene McCoy - Carl Ritter
- Elliot Levey - Michael Townsend
- Martha Cope - Janice Dunlop
- Rosa Escoda - Sarah-Jane Fleet
- Lianne Harvey - Jude Puncheon
- Philip Correia - Remi Abraham
- Robert Lonsdale - Clayton Pearson
- Irene Marot - Dora Taylor
- Sam Cox - Frank Taylor
- Marcia Lecky - Joy Ellis
- Sian Reese-Williams - Jodie Rodgers
- Cara Chase - Linda Rodgers
- Paul Sloss - Harry Everitt
- Zubin Varla - Rafi Raza
- Jonathan Howard - Declan Ashe
- Miles Mitchell - Alex Duval
- Calum Callaghan - Bobby Edwards
- Phoebe Pryce - Skylar Bryce
- Hannah Saxby - Jenny Dawes
- Ellie Piercy - Allegra Rankin
- Stephanie Siadatan - Georgia Butler
- Julian Moore-Cook - Nico Finefield
- Sianad Gregory - Hannah Pickering
- Debbie Korley - Michelle Brodey
- Abhin Galeya - Vikram Popat
- Manjinder Virk - Junior Nurse
- Doña Croll - Sanya Morrison
- Laila Rouass - Sahira Shah
- Raad Rawi - Reyhan Shah
- Polly Frame - Claire Reynolds
- Annette McLaughlin - Mags Vernon
- Amanda Wilkin - Jemima Thomas
- Samuel Menhinick - Finn Kearney
- Jacqui Dubois - Mary Trowler
- Isaiah Bobb-Semple - Kyle Griffin
- Karl Collins - Treve Harding
- Rachel Tucker - Kathy Peters
- Gina Gangar - Matilda Chibnall
- Steve North - Len Chibnall
- Ramin Karimloo - Kian Madani
- Kwami Odoom - Troy Christie
- Jonno Davies - Leo Powell
- Rachel Bright - Beth Miller
- Richard Frame - Dannie Waites
- Nicholas Shaw - Rory Lycett
- Conor Joseph - Ashley Parry
- Rebecca Benson - Kitty Johnson
- Ali Hadji-Heshmati - Abs Raza
- Mark Arden - Martin Duffy
- Delroy Atkinson - Delroy Jones
- Ameet Chana - Mohammed Jaziri
- Victoria Hamnett - Sara Walton
- Ryan Dean - Dayle Walton
- James Bradwell - River Henderson
- Amy Lennox - Chloe Godard
- Billy Boyle - Lennie George
- George Rainsford - Ethan Hardy
- Amy Forrest - Nicola Bates
- Debra Stephenson - Jeni Sinclaire
- Richard Pepper - Rich Peterson
- Richard Burke - David Knowles
- Briana Shann - Mia Barron
- Eloise Black - Jo Fields
- Emily Stride - Susan Johnson
- Joe Gaminara - Dylan Clark
- Cassie Bradley - Cassie Lockhart
- Paul Chan - Mr McConnell
- Carol Walton - Elaine Hudson
- Ajay Chhabra - Bashir Khan
- Sara Stephens - Tina Hardacre
- Chris Packham - Himself
- Karen Ascoe - Regina Marriott
- Karen Ascoe - Regina Marriot
- Vineeta Rishi - Lucky Simpson
- Phoebe French - Evie Fletcher
- Eileen Davies - Doreen Spicer
- Margot Leicester - Charlotte Donaldson
- Eileen Nicholas - Susannah Wetherley
- Anna Sari - Amber Richards
- Curtis Kemlo - Roger Brierley
- Gary McDonald - Thomas Abara
- Laura Lake Adebisi - Yasmeen Abara
- Julia Deakin - Carole Copeland
- Oscar Wilkins - Sammy Carrington
- Alison Pargeter - Wendy Carrington
- Darcy Isa - Sharmella Wilson
- Niamh Lynch - Hannah Spiceley
- Neil Fox-Roberts - Alan Sullivan
- Kate Lock - Moira Clark
- Harry Giubileo - Harry Carabello
- Michael Greco - Anthony Carabello
- Mike Grady - John Barton
- Pushpinder Chani - Sanjit Singh
- Aisling Bea - Amelia Warner
- Clare Clifford - Jay Harmsworth
- Lottie Tolhurst - Claudia Blaise
- Kimberley Okoye - Patricia Cole
- Hari Dhillon - Michael Spence
- Ged Simmons - Terry Britton
- Akbar Kurtha - Jonathan Latif
- John Michie - Guy Self
- Delainey Hayles - Billie Faber
- Byron Easmon - Larry
- Kaye Wragg - Estelle 'Essie' Di Lucca
- Lucinda Dryzek - Jasmine Burrows
- Zoe Aldrich - Anita Blaise
- Jules Robertson - Jason Haynes
- Chan Woo Lim - Jeong-Soo Han
- Jo Martin - Max McGerry
- Dawn Steele - Ange Godard
- Alex Walkinshaw - Adrian "Fletch" Fletcher
- Tyler Luke Cunningham - Louis McGerry
- Davood Ghadami - Eli Ebrahimi
- Clare Burt - Madge Britton
- Simon Slater - Russell "Russ" Faber
- Paul Bradley - Elliot Hope
- Jenny Howe - Alexandra 'Lexy' Dunblane
- Hamish Clark - Ken Davies
- Tracy Wiles - Helen Davies
- Alison O'Donnell - Wendy Weiss
- Catherine Hannay - Delia Kelly
- Alice Henley - Angelica-May Roberts
- Emma Fischer - Scarlett Ferguson
- Kelly Marcel - Rachel Hughes
- Leo Woodall - Jake Reader
- Koel Purie - Saleena Chowdhury
- Faith Elizabeth - Student Nurse (uncredited)
- Nicola Bryant - Reporter
- Nicola Bryant - Catherine Sloman
- Charles Simpson - Chris Kavanagh
- Lydia Fox - Paloma Duncan
- Robert Ryan - Visitor
- Hadley Fraser - Sebastian Coulter
- Klariza Clayton - Stevie Montague
- Louisa Connolly-Burnham - Rosie Greene
- Sabrina Bartlett - Gabriella 'Gabi' Mendoza
- Peter Sallis - Lionel Davis
- Simon Manyonda - Tommy Bevan
- Tom Beard - Mr. Solis
- Louise Delamere - Colette Sheward
- Shauna Shim - Ruth Evans
Danny Cunningham interpreta a Tom Woodley en la serie.
Akbar Kurtha hace el papel de Jonathan Latif.
Nicholas Hoult interpreta a Oscar Banks en la serie.
Capítulo disponible en las siguientes plataformas:
