- Henry Czerny - Luke
- Diana Leblanc - Frannie Halcyon
- Jackie Richardson - Emma Ravenel
- Sandra Oh - Bambi Kanetaka
- Joel Grey - Guido
- John McMartin - Royal Reichenbach
- Parker Posey - Connie Bradshaw Fetzner
- John Robinson - Cage Tyler
- Lea DeLaria - Willie Omiak
- Françoise Robertson - D'orothea Wilson
- Randy Thomas - Officer Bill Rivera
- Ted Whittall - Ned Lockwood
- Sheena Larkin - Claire McAlister
- Sara Bradeen - Jennifer Rabinowitz
- Donald Burda - Larry Keenan
- Marcel Jeannin - Carl
- Janine Theriault - Bobbi
- Mark Antony Krupa - Bear
- John Dunn-Hill - Rabbit Man
- Scott Thompson - Arlington Luce (uncredited)
- Max Walker - Jack (uncredited)
- Thierry Pépin - Motorcycle Thug (uncredited)
- Maurizio Terrazzano - Naked Man (uncredited)
- Armistead Maupin - Man Exiting Glory Holes (uncredited)
- Pierre Gang
- Celeste Lecesne
- Richard Hicks
- Armistead Maupin
- Alan Poul
- Suzanne Girard
- Tim Bevan
- Luc Châtelain
- Richard Grégoire
Olympia Dukakis interpreta a Anna Madrigal en la serie.
Paul Hopkins interpreta a Michael "Mouse" Tolliver en la serie.
Laura Linney hace el papel de Mary Ann Singleton.
Barbara Garrick interpreta a DeDe Halcyon Day en la serie.
Jackie Burroughs interpreta a Mother Mucca en la serie.
Whip Hubley interpreta a Brian Hawkins en la serie.
Billy Campbell interpreta a Dr. Jon Fielding en la serie.
Bruce McCulloch interpreta a Father Paddy en la serie.
Mary Kay Place interpreta a Prue Giroux en la serie.
Henry Czerny interpreta a Luke en la serie.
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