- Micah Stock - Jonah
- Dickie Hearts - Mateo
- Zosia Mamet - Claire Duncan
- Michael Park - Robert Watson
- Bob the Drag Queen - Ida Best
- Bryce Charles - Marlowe
- Alan Mingo Jr. - The Queen
- Stephanie Weeks - Flight Attendant
- Chengusoyane Kargbo - Mom
- Dierdre Friel - Cashier
- Erin Wilson - Orchid Woman
- Victor Garber - Samuel Garland
- Michelle Buteau - Wrenita Butler
- Juan Castano - Flaco Ramirez
- Samantha Soule - Inka Gisladottir
- Benjamin Thys - Eli Heller
- Erin Davie - Emma Grace
- Clyde Baldo - Cab Driver
- Viet Vo - The Monk
- Ali Nasser - Waiter
- Ashley Park - Jennifer 'Ani' Winter
- Daphne Rubin-Vega - Mrs. Rodriguez
- Matthew Risch - Harrison
- Elena Hurst - Linda
- Sebastian Chacon - Lucas
- Nelson Ascencio - Eduardo
- Jorge Cordova - Stuart
- Teddy Cañez - Uncle Mando
- Marquise Vilson - Palmer
- Ivory Aquino - Doctor Perez
- Brooks Ashmanskas - Paul
- Bryan Batt - Chris Bauer
- Dan Butler - Dan
- Malcolm Gets - Ken
- Taylor Mac - Ken
- Stephen Spinella - Chris
- Claudia Logan - Lay-La
- Brian McCarthy - Prius Driver
- Mary Louise Wilson - Doris
- Kate Rigg - Drag King
- Em Grosland - Homobile Driver
- Tedra Millan - Doula
- Gamze Ceylan - Officer Patel
- Catrina Ganey - Rainbow Readers Director
- Lio Mehiel - Mission Communal Guide
- Anna Suzuki - Lynn
- Cathryn Mudon - Woman at Yard Sale
- Fortune Feimster - Carlin
- John Glover - Bill Schwartz
- Danny Burstein - Buzz Bradshaw
- Jennifer Laura Thompson - Maura Bradshaw
- Katya Zamolodchikova - Wedding Waitress
- Dennis Stowe - George Bryce
- P.J. Brennan - Nate Goldberg
- James T. Kelly - Leather Twink
- Luke Kirby - Tommy Nelson (uncredited)
- Luke Kirby - Tommy Nelson
- Ryan Foust - Braden Bradshaw
- Armistead Maupin - Wedding Guest (uncredited)
- Daniela Vega - Ysela
- Eve Lindley - Lily
- Keilly McQuail - Joyce
- Tyler Elliot Burke - Boone
- Frank Deal - Sergeant
- Jari Jones - Ronda
- Irene Rising - Franny
- Clea Alsip - Nancy
- Kathryn Boswell - Judith
- Donnie Kehr - Bill
- Jen Richards - Anna Madrigal
- Jen Richards - Young Anna Madrigal (uncredited)
- Cadden Jones - Store Clerk
- Cascius LaFleur - Woman in Park
- Clem Cheung - Owner #1
- Yan Xi - Owner #2
- Adam Greer - Cop
- Molly Ringwald - Claire's Mother
- Josh Pais - Doug
- Katie Lee Hill - Tallulah
- Cliff Moylan - Steve
- Jon Shaver - Mark Duncan
- Doris McCarthy - Flight Passenger (uncredited)
- Lauren Morelli
- Gail Barringer
- Armistead Maupin
- Alan Poul
- Debbie Brubaker
- Adam Caldwell
- Jay Wadley
Clem Cheung interpreta a Owner #1 en la serie.
Laura Linney hace el papel de Mary Ann Singleton.
Elliot Page interpreta a Shawna Hawkins en la serie.
Paul Gross interpreta a Brian Hawkins en la serie.
Murray Bartlett hace el papel de Michael 'Mouse' Tolliver.
Charlie Barnett interpreta a Ben Marshall en la serie.
Garcia interpreta a Jake Rodriguez en la serie.
May Hong hace el papel de Margot Park.
Olympia Dukakis hace el papel de Anna Madrigal.
Barbara Garrick interpreta a DeDe Halcyon en la serie.
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