- Bibi Besch - Armelia
- Bill Paxton - Billy DeLuca
- Michael J. Fox - Prosecutor
- Humphrey Bogart - Lou Spinelli (archive footage)
- Jonathan Banks - William
- Brad Garrett - Drinky (voice)
- Joe Pantoliano - Casino Dealer (uncredited)
- David Warner - Dr. Alan Goetz
- Anders Hove - Emilio
- Tom Hanks - Baxter
- Brad Pitt - Billy
- Lea Thompson - Sylvia Vane
- Kirk Douglas - Gen. Kalthrob
- James Tolkan - Sgt. McClaine
- David Morse - Tom McMurdo
- Beverly D'Angelo - Janice Baird
- Ethan Suplee - Jaimie
- Tim Roth - Jack Craig
- Stephen Shellen - Charles
- Patricia Charbonneau - Ellen Renfield
- Alun Armstrong - Inspector Herbert
- M. Emmet Walsh - Jonas
- Arnold Schwarzenegger - X-Con (uncredited)
- Brion James - Steve Dixon
- Jeffrey Tambor - Charlie Marno
- Patricia Arquette - Mary Jo
- Sandra Bernhard - Sheila Winters
- Shelley Hack - Janet McKay
- Demi Moore - Cathy Marno
- Tony Goldwyn - Dr. Carl Fairbanks
- Brad Dourif - Virgil
- Alan Ruck - Carty
- Vincent Schiavelli - Robert
- Whoopi Goldberg - Peligre
- Dennis Farina - Antoine
- Benicio del Toro - Bill
- Amanda Plummer - Peggy
- Anthony Michael Hall - Reggie Skulnick
- Steve Buscemi - Ike
- Susan Blommaert - Luisa Yates
- Bob Hoskins - Redmond
- Eddie Izzard - Warhol Evans
- John Rhys-Davies - Duval
- Lance Henriksen - Reno Crevice
- Michael Lerner - Mr. Byrd
- Earl Boen - Mr. Clayton
- Rick Rossovich - Hans/Younger Carlton Webster
- Jon Polito - Nikos Stano
- Elizabeth McGovern - Laura Kendall
- Robert Patrick - Lothar
- Billy Zane - Miles Federman
- Roy Dotrice - Major Nicholson
- Treat Williams - Howard Prince
- Jeffrey Jones - Professor Finley
- Joe Pesci - Vic / Jack
- Burt Young - Gambler
- Lee Arenberg - Marty Slash
- Beau Bridges - Dr. Martin Fairbanks
- Ke Huy Quan - Josh
- Hector Elizondo - Leo Burns
- Dan Aykroyd - Captain Milligan
- James Remar - Red Buckley
- Robert Wuhl - Barker
- Mark Pellegrino - Punk
- Anthony Zerbe - Arnie Grunwald
- Jack Kehler - Joe's Mechanic
- Wil Wheaton - Arling
- Corey Feldman - Todd
- Marshall Bell - Husband
- Steve Coogan - Danny Skeggs
- Aubrey Morris - Freddy
- Bruce Boxleitner - Winton Robbins
- Ewan McGregor - Ford
- Charles Martin Smith - Colin
- Jon Tenney - Alex
- Patricia Clarkson - Suzy
- Richard Donner
- Robert Zemeckis
- Charles Skouras III
- Joel Silver
- David Giler
- Barry Josephson
- Danny Elfman
Bibi Besch hace el papel de Armelia.
Bill Paxton interpreta a Billy DeLuca en la serie.
Michael J. Fox interpreta a Prosecutor en la serie.
Humphrey Bogart interpreta a Lou Spinelli (archive footage) en la serie.
Jonathan Banks interpreta a William en la serie.
Brad Garrett interpreta a Drinky (voice) en la serie.
Joe Pantoliano interpreta a Casino Dealer (uncredited) en la serie.
David Warner interpreta a Dr. Alan Goetz en la serie.
Anders Hove hace el papel de Emilio.
Tom Hanks interpreta a Baxter en la serie.
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