- Jeanne Cooper - Louise Douglas
- Terry Frost - Sgt. Morris
- William Boyett - Officer Johnson
- William Boyett - Officer 3833
- Will J. White - Agent Ed Coleman
- Rhodes Reason - Al Miller
- Stuart Whitman - Bill Martin, skindiver
- Dyan Cannon - Jean Deesing
- Guy Williams - Officer Hansen
- Guy Williams - Jerry March
- Diane Webber - Woman
- Coulter Irwin - Steve Talbot
- Kathy Marlowe - Audrey Talbot
- Joe Brown - Mr. Hastings
- Peter Brocco - Arnold Blackwell
- Julian Upton - Bellhop Frank
- James Dobson - Bellhop William "Red" Richardson
- Nancy Howard - Angie, the patient
- Buck Young - Gas Station Attendant
- Don Kelly - Paul Lawson
- Jason Johnson - Company Manager
- Gayne Whitman - Dr. Kennedy
- Guy Prescott - Man From Cafe
- Brad Trumbull - Mickey Demarest
- Nancy Hadley - Rita Hollis
- Joe Cranston - Ranger Ben Seward
- Britt Lomond - Ptl. Melton, at headquarters
- Jonathan Hole - Roger Taylor
- Marie Stoddard - Ethel Corey
- Gene Reynolds - Henry Corey
- Marvin Press - Wilbur Morgan
- Michael Garrett - Patrolman Mike Peterson
- Robert Patten - Patrolman Mark Reynolds
- Dennis Cross - Bill Reynolds
- Rachel Ames - Mrs. Reynolds
- Watson Downs - Dad Reynolds
- Michael Mark - The Passing Motorist
- Ford Stevens - Paxton, the leader
- Leo V. Matranga - Curtis, the eater
- Charles Gray - Officer Edwards (#1430)
- George Becwar - Miles Lauber, the big boss
- Byron Keith - Officer Dillon
- Byron Keith - Highway Patrolman Bergen
- Patty Ann Gerrity - Little Girl on Beach
- John Hart - Sergeant at Headquarters
- Eleanore Tanin - Helen Tewell Barton
- Troy Melton - Joe Barton
- Margaret Irving - Irene Tewell, mother
- Bobby Watson - Ted Tewell, father
- Harry Hines - Mr. Dillon, witness
- Monty Ash - Police Lab Technician
- Alan Aric - Jimmy Higgins
- Guy Rennie - Charley Giddings
- William Hunt - Leroy Edwards, alias Frank Russell
- Glenn Dixon - Virgil
- Paul Sorensen - Steve Naylor
- Fritz Ford - Wilson, insurance investigator
- Kirk Alyn - Coordinating Officer at Headquarters
- James Stone - Warren Siddons, motorist
- Dan Starkey - Mr. Stedman
- Charles H. Gray - Area 3 Officer
- Charles H. Gray - A Highway Patrolman
- Harry Wilson - Customer in Restaurant
- Harry Wilson - Extra at Cafe Counter
- Emmaline Henry - Gloria Burgess
- John Close - 'Stash' Irwin
- Shirley O'Hara - Miss Carter
- Morgan Jones - The Highway Patrolman
- Morgan Jones - Officer 3822
- Morgan Jones - Officer on Phone
- Rayford Barnes - Seth Roberts
- Paul Engle - Jimmy James, the boy
- Lyn Guild - Cara Roberts
- Charles Postal - Mr. Williams
- Jack Finch - Mr. McGurrin
- Paul Richards - Jim
- Helene Stanton - Marge
- Tyler McVey - Red Lester
- Roy Bourgeois - Copter Pilot Roy
- Fran Bennett - Dolly Parker
- Don C. Harvey - Sanders
- Everett Glass - Dr. Taylor
- Francis McDonald - Charlie Barrett
- Bert Holland - Ed
- Forrest Taylor - Frank Wilkins
- Paul Hahn - Wilkins' Son (photo only) (misspelled Pual Hahn)
- Clark Howat - Officer Hank
- John Compton - Nick West
- Jack Edwards - Bernie Sills (Cafe Owner)
- Frederick Ziv
Clint Eastwood interpreta a Joe Keeley en la serie.
Broderick Crawford interpreta a Chief Dan Mathews en la serie.
Art Gilmore hace el papel de Narrator.
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