- Joel de la Fuente - Dr. Johann Pryce
- Kaniehtiio Horn - Destiny Rumancek
- Freya Tingley - Christina Wendell
- Penelope Mitchell - Letha Godfrey
- Lorenza Izzo - Brooke Bluebell
- Paul Popowich - JR Godfrey
- Eliana Jones - Alexa Sworn
- Laurie Fortier - Marie Godfrey
- Emilia McCarthy - Alyssa Sworn
- Dylan Trowbridge - Nose
- Marty Adams - Neck
- Jennifer Gibson - Mrs. Banks
- Shiva Negar - Brunette
- Alanis Peart - Mrs. Pisarro
- Rachel MacMillan - Jogger
- Ted Dykstra - Francis Pullman
- Holly Deveaux - Jenny Fredericks
- Don Francks - Nicolae
- Emily Piggford - Ashley Valentine
- Landon Norris - Tyler
- Steve Lund - Bartender
- Philip Craig - Bishop Francis
- Jacob Switzer - Freshman Boy 2
- Krista Marchand - Sleepy Woman
- Jasmin Geljo - Moustache
- Carolyne Maraghi - Caroline
- Nicole Muñoz - Hermila
- Martin Roach - Guard
- Patrick Garrow - Theodore Gibson (as Patrack Garrow)
- Anne Yorke - Gypsy
- Luke Camilleri - Andreas Vasilescu
- Demore Barnes - Michael Chasseur
- Shauna MacDonald - Dr. Galina Zheleznova-Burdukovskaya
- Michael Therriault - Dr. Klaus Blinsky
- Mark Walker - Conway
- Amanda Smith - Anna
- Alex Gordon - Prycilla / Female Humanoid
- Adam Rodness - Trevor
- J.C. MacKenzie - Dr. Arnold Spivak
- Lisa Marcos - Leticia Padilla
- Mouna Traoré - Ali
- Jack Fulton - Jason Blevins
- William deVry - Chin
- Rick Hughes - Mr. Willoughby
- Helen King - Librarian
- Priya Rao - Librarian 2
- Marlaina Andre - Mother
- David Richmond-Peck - Mr. Beaumont
- Kyle Mac - Dom
- Niamh Wilson - Pretty Shelley
- Anthony J. Mifsud - Greek Delivery Man
- James Cade - Bajram
- Mark Cowling - Prophet
- David Paul Francis - Vlad Wojack
- Edie Inksetter - Jack's Mom
- Michael Ayres - Skar
- Michael Ayres - Emir
- Mal Dassin - Nik / Streak of White
- Garrett Hnatiuk - Stephan / Heterochromia
- Erika Ervin - Shelley Godfrey (Body)
- Meegwun Fairbrother - Milan Faber
- Mercedes de la Zerda - Sophia
- Michelle Zlomislic - Nurse
- Juan Carlos Velis - Xavier
- Julian Richings - Swiss Doctor
- Jake Manley - Boy 1
- Rosalba Martinni - Housekeeper
- Scott Gorman - Mechanic
- Robert Morse - Art Class Teacher
- Adam Waxman - Police Photographer
- Jack Giffin - Young Peter
- Michael Dyson - Coroner
- Anna Starnino - Drinker
- Henry Alessandroni - Drinker #2
- Garfield Andrews - Drinker #3
- Linda Goranson - Magdalena
- Joe Bostick - Vice Principal
- Joe Bostick - Boardroom Member #7
- Joe Bostick - Vice Principal (voice)
- Joe Bostick - Boardroom Member #6
- Danijel Mandic - Upir Nazi
- Robert Fulton - Ears
- Eric Fink - Bookstore Owner
- Kevin Hare - Mr. Fredericks
- Sergey Shpakovsky - Morgue Worker
- Vitalie Ursu - Servant
- Kiara Glasco - Young Olivia
- Christian Bako - Olivia's Father
- Daniele Monticelli - Dimitri
- Tom Bolton - Christina's Grandparent
- Meg Walter - Christina's Grandparent
- A.C. Peterson - Templar's Owner
- Ted Ludzik - The Visitor
- Brody Bover - Boy
- Costin Manu - Uncle Fonzo
- Neil Girvan - Detective
- Daniela Barbosa - Lauren
- Elias Edraki - Kurt
- Victor Sutton - Old Gypsy Man
- Maria Lerinman - Healani (Hawaiian Woman)
- Cotton Mather - Ohio State Trooper 2
- Jake Loube - Ohio SWAT Officer 1
- Dave Van Zeyl - Romani Clan Man 1
- Loretta Yu - Nadine
- Andrew Musselman - Davy
- Eric Woolfe - Desk Clerk
- Phil Morrison - Correctional Guard
- Louis Paquette - Alabaster Man 1
- Samuel Faraci - Jack
- Scott Cavalheiro - Cop / Zealot
- Melody Johnson - Darla
- Doug MacLeod - Limpert
- Deanna Jarvis - Hot Girl
- Allan Aarons - Old Guy at Trailer Park
- Tyler Stentiford - Danny
- Ramona Milano - Brenda
- Elle Downs - Gwen Epps
- Phillip Jarrett - Aquarius
- Tony Munch - Eddie Blevins
- Bridget Graham - Lori
- William Colgate - Cellmate
- Michael Boisvert - Guard #1
- Matt Birman - Ohio State Trooper 1
- Matt Birman - Terzo
- Jimmy Makris - Guard #2
- Thomas Darya - Shade Club Waiter
- Karen Parker - Lurleen Blevins
- Margaret Lamarre - Jason's Grandma
- B.J. McQueen - Loisa
- Janaya Stephens - Michelle
- Ivan Wanis-Ruiz - Emilio
- Marcia Bennett - Donna Thurgood
- Olivia Barrett - Shandryce
- Michael Crawford - White Tower Med Tech
- Tsu-Ching Yu - Zealot #3
- Charles Papasoff - 1884 Chancellor of the Order
- Janine Theriault - Female Chancellor of the Order
- Curtis Parker - Zealot #2
- Curtis Parker - Zealot #1
- Noah Dalton Danby - Caul Member
- Andrew Moodie - Dr. Foster
- Tomas Chovanec - Primo
- Vivien Endicott Douglas - Zealot #2
- Géza Kovács - Gypsy
- Sarah Booth - White Tower Nurse
- Rothaford Gray - Blazer
- Mark Gibson - SWAT Team Leader
- Steve Lucescu - White Tower Security #1
- William MacDonald - Jeargen Knauff
- Geoffrey Antoine - Prosecuting Attorney
- Brian Paul - Chairman of the Board
- Brian Paul - Chester McAvoy
- Laura de Carteret - Ricki Gans
- Charles Seminerio - Minister
- Charles Seminerio - Priest
- Kevin Hanchard - Federal Agent Morgan
- Krystal Kiran - Roman's Lawyer #2
- Merwin Mondesir - Bartender
- Laara Sadiq - Judge Sheila Kapoor
- Robin Ward - Priest
- Wayne Ward - Federal Agent Clay
- Madeline Brewer - Miranda Cates
- Ayesha Mansur Gonsalves - Layla Masri
- Dalmar Abuzeid - Suresh
- Sean Rey - Frizz
- Cassius Crieghtney - Riemsdyk
- Alexander Conti - Kessell
- James Madge - Dad
- Gavin MacIver-Wright - Kid #2
- Tig Fong - Quarto
- Tig Fong - Man
- Robert Levine - Elderly Man
- Sebastian Deery - Naked Man
- Christopher Jacot - Nate Lowenstein
- Diana Bentley - Hannah
- Deborah Tennant - Julia Hughes
- Ace Hicks - Megan Whitney
- Neil Foster - Mickey Hughes
- Piper Hook - Giggling Girl
- Ron Kennell - The Tongue
- Earl Pastko - Shandor Bibinkian
- James Binkley - Guard
- Eli Ham - Darryl
- Richard Donat - McDougal
- Erin Agostino - Abbie
- Bishop Brigante - Tire Iron
- Jordan Madley - Laleh
- Tara Joshi - Kerrington
- Simon Sinn - Dr. Shizuo Pryce
- Lukas Engel - Young Pryce (9)
- Keana Bastidas - Kid #2
- Araya Mengesha - Puppet
- Paquito 'Paco' Hernaci - Detective Garcia
- Bernard Kay - Neighbor
- John Blackwood - Uncle Popa
- Goran Slavković - Bartender
- Anastasia Marinina - Rebecca
- Richard Gunn - Aitor Quantic
- Milton Barnes - Detective Cullen
- Jason Burke - Ned
- Claire Rankin - Celeste Charles
- Sagine Sémajuste - Woman in the Crowd
- Ray Kahnert - Boardroom Member #1
- Reg Dreger - Boardroom Member #2
- Kristian Truelsen - Boardroom Member #6
- Ian Deakin - Boardroom Member #8
- Sharon McFarlane - Boardroom Member #9
- Michael Dufays - Security Guard
- Andrew Shaver - Zach Israel
- Scott McCord - Norville Knox
- Brendan Murray - Middle Aged Man
- Neil Whitely - Randolph
- Clark Backo - Lydia Lourdes
- Alex Hernandez - Isaac Ochoa
- Monica Dottor - Prompter
- Emmanuel Kabongo - Marshall
- Jessica Clement - Cherry
- Jameson Kraemer - Stage Manager
- Shauna Bradley - Saban
- Carlos Fortin - Security Guard
- Shereen Ladha - Bollywood Dancer #1
- Yanna McIntosh - Frieda the Lawyer
- Anthony Grant - Viz
- Stephane Garneau-Monten - Homeless Junkie
- Greg Campbell - Boardroom Member #4
Julian Richings interpreta a Swiss Doctor en la serie.
Lili Taylor interpreta a Lynda Rumancek en la serie.
Landon Liboiron hace el papel de Peter Rumancek.
Bill Skarsgård hace el papel de Roman Godfrey.
Famke Janssen interpreta a Olivia Godfrey en la serie.
Madeleine Martin hace el papel de Shelley Godfrey.
Camille De Pazzis interpreta a Annie en la serie.
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