- Ricardo Montalban - Alex Pareno
- Peter Lawford - Kenneth Kirk
- Lisa Eilbacher - Elaine Sebastian
- Marie Windsor - Gloria Marshall
- Stephen Elliott - Enslow
- Abe Vigoda - Abe Kemper
- Mark Lenard - Commander Hawkins
- George Murdock - Hank Merrill
- Frank Gorshin - Stash
- Tom Skerritt - Lew Morgan
- George DiCenzo - Yuri Bloch
- John Marley - Noah Kaluna
- Edward James Olmos - Dancer
- Christopher Walken - Walt Kramer
- R. G. Armstrong - Warden
- Robert Ellenstein - Bart Warren
- Nehemiah Persoff - Allie Francis
- Edward Binns - Mills
- Anthony James - Hutch
- Robert Loggia - Russ Hendrix
- Leonard Stone - Herman Stein
- Paul Shenar - Todd Daniels
- Diana Scarwid - Carole Walker
- Buddy Ebsen - Professor Ambrose Pierce
- Robert Foxworth - Dr. Eric Fowler
- Earl Boen - Denisovich
- Mel Ferrer - Emil Radick
- Doreen Lang - Emilia Watson
- Charles Durning - Havens
- Richard Davalos - George Hawley
- Annette O'Toole - Sue
- Clyde Kusatsu - Jerry Quan
- David Huddleston - Vincent Rhoads
- Sal Mineo - Eddie
- William Shatner - Sam Tolliver
- Anthony Zerbe - Cord McKenzie
- Pat Hingle - Grant Ormsbee
- Lew Ayres - Comm. Reginald Blackwell
- Kelly Bishop - Char
- George Takei - Nathaniel Blake
- Ian Wolfe - Mr. Miller
- Bruce Boxleitner - Paul Colburn
- Barnard Hughes - Clinton Palmer
- Gary Lockwood - Kelsey
- Richard Romanus - Johnny Noah
- Jack Kruschen - Blumberg
- William Smith - Det. James 'Kimo' Carew
- Richard Denning - Governor
- Sharon Farrell - Lori Wilson
- Larry Stewart
- Bob Sweeney
- Bill Finnegan
- Leonard Katzman
- Leonard Freeman
- Philip Leacock
Ricardo Montalban interpreta a Alex Pareno en la serie.
Peter Lawford interpreta a Kenneth Kirk en la serie.
Lisa Eilbacher interpreta a Elaine Sebastian en la serie.
Marie Windsor interpreta a Gloria Marshall en la serie.
Stephen Elliott hace el papel de Enslow.
Abe Vigoda hace el papel de Abe Kemper.
Mark Lenard interpreta a Commander Hawkins en la serie.
George Murdock hace el papel de Hank Merrill.
Frank Gorshin interpreta a Stash en la serie.
Tom Skerritt interpreta a Lew Morgan en la serie.
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