- Rafael Campos - Doroteo
- Jeremy Slate - Frank DeWitt
- Jack Lord - Dave
- Paul Fix - Sheriff Stinchcomb
- Victor McLaglen - Mike O'Hare
- Robert Karnes - Joe Peavey
- Harry Shannon - Jesse
- Susan Cabot - Becky Gray Carver
- Don Keefer - Kelso
- Peter Falk - Waller - Gambler
- John Fiedler - James Turner
- Duane Eddy - Young Cowboy
- Peggy Stewart - Sarah Holt
- Kam Tong - Hey Boy
- Roy Barcroft - Sgt. Barsky
- Walter Reed - Captain
- George Kennedy - Deke - Killer
- Kent Smith - Avery Coombs
- Larry Pennell - Henry Carver
- Lawrence Dobkin - Billy-Joe Kane
- Hal Smith - Bartender
- Hal Smith - George the Desk Clerk
- Joseph V. Perry - Drunk
- Barney Phillips - Joseph Ergo
- Philip Ahn - W. Chung
- Janice Rule - Nancy
- Len Lesser - Boldt
- William Talman - George Jondill
- Don 'Red' Barry - Tom Goodfellow
- Denver Pyle - Pete Hollister
- Jacqueline Scott - Nora Larson
- Hal Needham - Harry Beldon
- Hal Needham - Gleet
- James Coburn - Jack Harvey
- Vic Perrin - Rheinhart
- Richard Reeves - Jerris
- Charles Bronson - Manfred Holt
- Jeanette Nolan - Alice Ferguson (AKA Blue Dollar Alice)
- Chris Drake - Dark Youth
- William Fawcett - Jake
- Angie Dickinson - Amy Bender
- Grant Withers - Jeremiah Mulrooney
- Grant Withers - Sam Barton
- Grant Withers - Sheriff Ludlow
- Leonid Kinskey - Yevgeny
- Mike Mazurki - Power
- Mike Mazurki - Breed
- Ken Curtis - Monk
- Ken Curtis - Skinner Monk
- Judson Pratt - O'Brien
- Harry Carey, Jr. - Jess Turner
- Harry Carey, Jr. - Ben Murdock
- Harry Carey, Jr. - Frank Gulley
- Anthony Caruso - Joseph Whitehorse
- Claude Akins - Dever
- John Larch - McNagle
- Peter Brocco - Younghusband
- Peter Brocco - Samuels - Bureau of Territorial Records Rep
- Peter Brocco - Clerk
- R. G. Armstrong - Mayor Lovett
- Jay Novello - Baron Otto von Albrecht
- Gene Roth - Man
- Mason Curry - Manager
- Earle Hodgins - Old Timer
- Martín Garralaga - Peon
- Kevin Hagen - Jory - Townsman
- Kevin Hagen - Judd Bowman
- Francis McDonald - Gotch (as Francis MacDonald)
- Edward Faulkner - Ben (as Ed Faulkner)
- Theo Marcuse - Bartender (as Ted Marcuse)
- Paul Ravel - Barfly (uncredited)
- Norman Stevans - Hotel Guest (uncredited)
- Bert Stevens - Hotel Guest (uncredited)
- Arthur Tovey - Hotel Guest (uncredited)
- Steve Mitchell - Gage
- Barry Cahill - Abe Talltree
- Lee Van Cleef - Corbin
- Peter Breck - Frank Weaver
- Jonathan Hole - Elkins
- Albert Cavens - Townsman (uncredited)
- Albert Cavens - Hotel Guest (uncredited)
- Buddy Ebsen - Marshal Elmo Crane
- John Bose - Townsman (uncredited)
- Rita Lynn - Elise Banjo Jones
- Perry Ivins - Veterinarian (uncredited)
- Jack Lilley - Townsman (uncredited)
- Mathew McCue - Townsman (uncredited)
- Tom McDonough - Henchman (uncredited)
- Paul Palmer - Townsman (uncredited)
- Bob Reeves - Townsman (uncredited)
- Bruce Gordon - Louis Dryden
- Phil Schumacher - Tex (uncredited)
- Cap Somers - Townsman (uncredited)
- Quentin Sondergaard - Townsman (uncredited)
- Lisa Lu - Hey Girl
- Lisa Lu - Kim Li
- Tom Smith - Townsman (uncredited)
- Carol Thurston - Martha Whitehorse
- James Parnell - Sheriff (as Jim Parnell)
- George Bell - Cowhand (uncredited)
- Forrest Burns - Townsman (uncredited)
- Herman Hack - Townsman (uncredited)
- Chick Hannan - Shotgun Rider (uncredited)
- Helene Stanley - Yvonne
- Warren Oates - Harrison
- Cyril Delevanti - Cornish - Storekeeper
- Cyril Delevanti - Speedy Deliverer
- June Lockhart - Dr. Phyllis Thackeray
- Sam Gilman - Laird (uncredited)
- Fred Graham - Stocker
- Lisa Montell - Soledad Ortega
- John Mitchum - McHeath
- Edward Colmans - Don Luis Ortega
- John George - Townsman (uncredited)
- John George - Barfly (uncredited)
- John George - Score Keeper (uncredited)
- John George - Hotel Carlton Shoe Shiner (uncredited)
- John George - Padre (uncredited)
- John George - Marcher (uncredited)
- Leo Gordon - Deputy Moley
- Leo Gordon - Harkness
- Leo Gordon - Bert Talman
- Leo Gordon - Clyde McNally
- Hal Taggart - Hotel Guest (uncredited)
- Hal Taggart - Court Clerk (uncredited)
- Jack Elam - Arnold Shaffner
- Joanna Barnes - Penelope Lacey
- James Brown - Andrews - Ranch Foreman
- Forbes Murray - Hotel Guest (uncredited)
- Charles H. Gray - Jeff Sunderland
- Charles H. Gray - Cavalry Lieutenant
- Lon Chaney Jr. - William Ceilbleu
- Lon Chaney Jr. - O'Connor - Inmate
- Raymond Hatton - Eph Trager
- Raymond Hatton - Perce Weber - Bounty Hunter
- Raymond Hatton - Mayor Trevor
- Strother Martin - Fred Coombs
- Strother Martin - Carew
- Larry J. Blake - Deputy
- Dick Rich - Sheriff Jim Toby
- Dick Rich - Sheriff Clyde
- Warren Parker - Ned Alcorn
- Warren Parker - Hotel Carlton Desk Clerk
- Warren Parker - Clerk
- Antoinette Bower - Sybil Lansing
- William Swan - Tracey Calvert
- Russell Custer - Townsman (uncredited)
- George E. Stone - Joe Roland
- Pernell Roberts - Maury Travis
- John Alderson - Max Clay
- Morey Amsterdam - Lucien Bellingham
- Rocky Shahan - Gang Member (uncredited)
- Rocky Shahan - Stage Driver
- Herschel Graham - Hotel Guest (uncredited)
- Herschel Graham - Hotel Carlton Guest (uncredited)
- Herschel Graham - Townsman (uncredited)
- Herschel Graham - Father (uncredited)
- Lovyss Bradley - Townswoman (uncredited)
- Lovyss Bradley - Wife (uncredited)
- John Daheim - Pitcher
- Ted Hamilton - Catcher
- Robert Dornan - Dandy
- Roy Engel - Piano Thief (uncredited)
- Roy Engel - Matson
- Ted de Corsia - Chief Harry Blackfoot
- Stuart Whitman - Gil Borden
- Jean Allison - Nora Borden
- Robert Blake - Jessie May Turnbow
- Robert Blake - Smollet - Bully
- Robert Blake - Lauro - Mexican Man
- Hari Rhodes - Ansel James
- Perry Cook - Ernie - Card Player
- Perry Cook - Sheriff Fix
- Perry Cook - Hotel Proprietor Briggs
- Lee Farr - Paul Martin
- Naomi Stevens - Marga
- Naomi Stevens - Ma Kafka
- Adam Williams - Frank Gault
- Adam Williams - Simon Quill
- Adam Williams - Beckett
- Olive Sturgess - Helen Martin
- Albert Salmi - Father Montalvo
- James Franciscus - Tom Nelson
- David Baker - Henchman
- Andrew Duggan - Daniel Weaver
- Lana Wood - Becky Coldwell
- Raymond Bailey - Walter B. Jonas M. D. (uncredited)
- Raymond Bailey - John Staffer
- Raymond Bailey - Clyde Barnes
- J. Pat O'Malley - Logan
- J. Pat O'Malley - Marcus Goodbaby
- Jack Hogan - Chris Rook
- Jack Hogan - Joel Weaver
- Jerry Gatlin - Weaver
- Jerry Gatlin - 1st Deputy
- John Harmon - Trowbridge - Guard
- John Harmon - Stationmaster (uncredited)
- L.Q. Jones - Hector
- L.Q. Jones - Bill Renn - Cowboy
- Herbert Rudley - Henry Ritchie
- John Doucette - Ed Rance
- John Doucette - Joe Marsh
- Fay Baker - Mrs. Grayson
- Richard Long - Rod Blakley
- Jay Adler - Bottellini
- Kenneth Tobey - Tim Decker
- Tom Kennedy - Townsman (uncredited)
- Richard Shannon - Jim Rook
- Richard Shannon - Escort
- Richard Shannon - Ben Jackson
- Richard Shannon - Eli Morgan
- Richard Shannon - Dr. Weiser
- Olive Carey - Shopkeeper
- Robert Adler - Sheriff
- DeForest Kelley - Deakin
- Buck Taylor - Eddie
- Andrew Prine - Billy Lamport
- Andrew Prine - Bobby Olson
- Marian Seldes - Mollie Stanton
- Marian Seldes - Christie Smith
- Willis Bouchey - Max Bender
- Harold J. Stone - Holgate
- Harold J. Stone - Judge Greenleaf
- Harold J. Stone - Samuel Abajinian
- Bob Woodward - Gruber
- Bob Woodward - Barfly (uncredited)
- Bob Woodward - Jerry
- Bob Woodward - Floyd
- Bob Woodward - Sheriff
- Harry Morgan - Sheriff Ernie Backwater
- Harry Morgan - Fred Braus
- Ron Hagerthy - Joe Martin
- Pitt Herbert - Sim tne Barber
- Madlyn Rhue - Jean Nelson
- Madlyn Rhue - Elizabeth DeVries
- Brad Weston - Quanah Parker
- Brad Weston - Miner
- Dorothy Dells - Emmy Bartlett
- Dorothy Dells - Mrs. Fred Wade
- Dorothy Dells - Jacqueline Webster
- Dorothy Dells - Mary Murdock
- Dorothy Dells - Saloon Gal
- Dorothy Dells - Woman
- Dorothy Dells - Madge Mattock
- Paul Sorensen - Herb - Doris' Helper
- Paul Sorensen - Pete
- William Woodson - Circus Barker
- Eve McVeagh - Katherine Parsons
- Joan Swift - Paladin's Love Interest (uncredited)
- George Cisar - Marshal
- George Cisar - Matt Perk
- Byron Foulger - Undertaker
- Robert F. Simon - Samuel Keel
- Robert F. Simon - Morgan Gibbs
- Mike Connors - Johnny Dart
- Robert Anderson - Sam Dolan
- Stewart East - Lt. Bradley
- Shirley O'Hara - Mrs. Carver
- Carol Henry - Henchman
- Elinor Donahue - Letty Mae Stinchcomb
- George Brenlin - Eph Jenkins
- Barry Brooks - G. L. Stevens - Drummer
- Sydney Pollack - Joe Culp
- Robert J. Wilke - Casey Bryan
- Robert J. Wilke - Will Tybee
- Robert J. Wilke - Trail Boss Rook
- Robert J. Wilke - Walt DeVries
- Robert J. Wilke - Maj. Blake
- William Challee - Sam Osser
- Robert Emhardt - Ray Remy
- Robert Emhardt - Sam Hodges / Courtney Burgess
- Robert Emhardt - Amos
- Wayne Rogers - Daniel
- Gale Garnett - Prudence
- Bob Steele - Jockey
- James Drury - Tony DeVries
- Mark Tapscott - Tom Semper
- Sam Rolfe
Naomi Stevens hace el papel de Marga.
Jay Adler hace el papel de Bottellini.
Leonid Kinskey interpreta a Yevgeny en la serie.
Robert J. Wilke interpreta a Will Tybee en la serie.
Ted de Corsia hace el papel de Chief Harry Blackfoot.
R. G. Armstrong interpreta a Mayor Lovett en la serie.
Adam Williams interpreta a Simon Quill en la serie.
George E. Stone hace el papel de Joe Roland.
Charles Bronson hace el papel de Manfred Holt.
Buddy Ebsen interpreta a Marshal Elmo Crane en la serie.
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