- Harrison Gilbertson - James Reed
- Anna Lise Phillips - Stephanie Tolson
- Robyn Malcolm - Maxine Pavich
- Mirrah Foulkes - Soroya Dass
- Gary Sweet - Bruce Reimers
- Luke Pegler - Kurt Calanna
- Ashlee Lollback - Cerise Warren
- Mercia Deane-Johns - Sofia Calanna
- Tracie Filmer - Security Guard
- Danxia Yang - Registrar
- Megan Smart - Charlotte Cumerford
- Patrick Cullen - Blake Poyner
- Leon Cain - Lufton
- Piéra Forde - Anna
- Kiara Freeman - Girl #2
- Laura Keneally - Medical School Dean
- Russ Gallagher - Dog Walker (uncredited)
- Jason Virgil - Plain Clothes Detective (uncredited)
- Lynette Curran - Millicent Bruce
- Peter Feeney - Alister Penn
- Emma Wright - Lena Penn
- Kristof Kaczmarek - Michael Abalard
- Aaron Davison - Wayne
- Roxanne McDonald - Principal
- Tracey Lee Maxwell - Louise
- Chris Haywood - Connelly
- Zindzi Okenyo - Sally Chenery
- Kamil Ellis - Noah Dalton (15 yrs)
- Tanya Schneider - Narelle Mearen
- Cory Beeston - Security Guard
- Kate Boladian - Grace Mulgrew
- Nicholas Brown - Dr. Peter Sharma
- Michael Balk - Constable
- Janelle Bailey - Mrs. Mulgrew
- Kyle McCallion - Lab Tech
- Mick Van Moorsel - Truck Driver
- Doris Younane - Sue Latchford
- Gary Young - Harry Wei
- Ari Boyland - Janik Hartmann
- Astrid Wells Cooper - Deputy Principal
- Vico Thai - Wei's Bodyguard #1
- Carmel Rose - Hotel Manager
- Rowan Howard - Security Guard #1
- Ed Wightman - Yellowly
- Laura Gordon - Audrey Matheson
- Andrew Buchanan - Inspector Kiriakos
- Joe Klocek - Sean Paulson
- Jack Stratton-Smith - Luke Chambers
- Harli Ames - Marcus Weir
- Jon Prasida - Ash Elrahi
- Fiona Choi - Anita Durete
- Neil Stoddart - Police Diver
- Tara Wraith - Constable (uncredited)
- Dorian Nkono - Lewison
- Melissa Bonne - Jo
- Dan Ewing - Rallings
- Maggie Blinco - Judy Adams
- Ivar Kants - Michael Wagner
- Kent Lee - Task Force Officer (uncredited)
- Uli Latukefu - Jesse Walsh
- Ditch Davey - Robert Quinn
- Wayne Huang - Detective Wagner's Partner (uncredited)
- Wayne Huang - Detective Wagner's Partner / Passerby (uncredited)
- Joel Tobeck - Tom Pinfold
- Chrissie Page - Mrs. Whitmore
- Christopher Sommers - Detective Leichhardt
- Grant Bowler - Francis Chester (voice)
- Pacharo Mzembe - Jacob Diallo
- Amali Golden - Sherry Diallo
- Elizabeth Ingham - Paramedic
- Ariu Lang Sio - Skene's Lawyer
- John Reynolds - Drug Squad Officer
- Catriona Toop - Ashlee Mackenzie
- Christian McCarty - Railway Worker
- Candice Hill - Xantia Couttas
- Caleb Stanley - Council Worker
- Emily Havea - Turua Parata
- Joe Feeney - Ewan
- John Sterling Carter - John Doe
- Ida Conte - Grandmother Capello
- Montana Jones - Gianna Capello
- Ilai Swindells - Billie Radbourne
- Damion Hunter - Phil Ritson
- Michael Deed - Debt Collector
- Jayden McGinlay - Young Boy (10 yrs)
- Emily Bell - Holly Ostwald
- Ben Wood - Julian Paulson
- Eric Wilson - Officer
- Rachel Forsyth - Detective Tina Stoltz
- Clementine Anderson - MFL Delivery Person
- John McNeill - Royce Gannon
- Richard Green - Lindsay
- Caitlyn Leo - Perfusionist
- Scott George - Police Officer
- Emily Gruhl - Anna Michaud
- Jaime Ureta - Luca Fandiño
- David Barranquero - Tomas Fuentes
- Francisco Lopez - Dr. Resende
- Lisa Flanagan - Melissa Turner
- Steve Nation - Ron Evans
- Lafe Charlton - Kyle Jackson
- Jackson Raine - Stuart Leong
- Richard Cawthorne - Paul Haberecht
- Hayden Maher - Young Paul
- Bridget Webb - Polly Haberecht
- Richard Brancatisano - Sergeant Gabriel Capello
- Erroll Shand - Brendan Skene
- Sachin Joab - Robert Chaudhari
- Ellen Bailey - Dr. Vicki Malisano
- Jack Martin - Ash Klenyhans
- David Cook - Fire Chief
- Daniel Widdowson - Bouncer
- Brad McMurray - Ross Moran
- Lisa Campos - Karen Chanson
- Tony Nixon - Glenn Falknow (Bookie)
- Edwina Bishop - Anita (Barmaid)
- Oakley Kwon - Neighbour
- Frances Marrington - SOCO
- Christopher Morris - Senior Sergeant Colin Fairley
- Sally McKenzie - Beverly McIntyre
- Anthony Standish - Tim Markides
- Mia Morrissey - Kyra Greene
- James Lugton - Bob Shepard
- Sallyanne Ryan - Ruth Cameron
- Helen Howard - Val Little
- Kate Peters - Judy
- Melanie Jarnson - Taylor Ford
- Korey Williams - Henchman #2
- Korey Williams - Drug Squad Officer
- Nicole da Silva - Danica
- Jason Wilder - Connor Harris
- Airlie Dodds - Rebecca McDonald
- Ling Cooper Tang - Dr. Sally Peterson
- Neveen Hanna - Rhonda Roberts
- Robin Queree - Howard Hobson
- Allison Cratchley - Isabella Hobson
- Tina Bursill - Alice Hobson
- Fraser Anderson - Will Hobson
- Maha Wilson - Nenet Botro
- Simon Elrahi - Ufa Sabry
- John Batchelor - Clayton Pike
- Angela Olyslager - Lead Customs Officer
- Geoff Morrell - Dr. Laurie Badcoe
- Lasarus Ratuere - Miles Hendry
- Kerith Atkinson - Dr. Beatrix Henshall
- Heather Mitchell - Louise Whitehall
- Patrick Frost - Dr. Maurice Chester
- Marty Rhone - Dr. Harry Briggs
- Nicholas Cooper - Security Guard
- Tasneem Roc - Jill McCloud
- Josephine Flynn - Detective
- Ellie Popov - Lab Assistant Julie Sewell
- Shanay De Marco - Admin Clerk (Dept of Health)
- Warwick Comber - Peter Morrow
- Anni Finsterer - Di Baverstock
- Jessica Clarke - Emily Morrow
- Alex Cusack - Jordy
- Jasper Bagg - Neil
- Cecilia Low - Duty Nurse
- Jacy Lewis - Mother
- Adam Hedditch - Husband
- Michael Bishop - Justin Long
- Chris Bartholomew - Leo Little
- Scott Johnson - Rev. Joshua Mercado
- Marta Kaczmarek - Ruth Kovacs
- Anthony Brandon Wong - Dave Young
- Alfredo Malabello - Andrei Kovacs
- Rumi Kikuchi - Erin Young
- Alison Whyte - Ursula Wells
- Charles Wu - Nate Young
- Michelle Lim Davidson - Izzy Young
- Michael Priest - Dr. David Bradley
- Michael Cuckson - Officer Pat Sloane
- Matthew Backer - Theo
- Amanda O'Dempsey - Scene of Crime Officer (uncredited)
- Brendan Bacon - Branch Goddard
- Chris Matheson - Whitman Goddard
- Kip Gamblin - Vincent / State Ranger
- Mark Furze - Ruben
- Kaiya Jones - Madison Moreland
- Parker Little - Mitchell Vanderhaust
- Virginie Laverdure - Superintendent Bec Crowley
- Virginie Laverdure - Superintendant Crowley
- Stuart Lumsden - Tractor Driver
- Sandy Winton - Ian Vanderhaust
- Ian Bolt - Leonard Thompson
- Rhonda Doyle - Brenda Sallow
- Finn Little - Cooper Bryant
- Travis McMahon - Terry Penn
- Wilson Moore - Alex Bryant
- Georgina Naidu - Alison Chen
- Ben Peel - Myles Finney
- Rupert Reid - Derek Moore
- Liliya May - Yelena Grishenko
- Stephen Lopez - Carl Echeverria
- Shanyn Asmar - Emcee
- Vincent B. Gorce - Ruslan
- Kyryl Koltsov - Yelena's bodyguard
- Adam Pierzchalski - Russian agent #2
- Tim Ross - Dr. Ben Patterson
- Tim Ross - Ben Patterson
- Daniel Nelson - Hotel Security #1
- Tony Barry - Jack Twine
- Ian Bliss - Charlie Oberg
- Felicity Soper - Faye Alsop
- Janet Andrewartha - Mrs. Peek
- Alex Time - Henchman #1
- Alex Time - Henchman
- Roz Hammond - Karen Yancy
- Russell Krause - Martin Peek
- Kestie Morassi - Emeline Mellis
- Steven Rooke - Detective
- Hugh Parker - Doug Hinton
- Sophia Emberson-Bain - Sage Wu
- Danielle Horvat - Naomi Sharpe
- Chris Hillier - Uniform Officer
- Chris Hillier - Senior Officer
- Julian Maroun - Aaron Sharpe
- Jessica Napier - Jade Freeman
- Diana Glenn - Mila Zoric
- Diana Glenn - Mila Zoric (uncredited)
- Andrea Moor - Pat Vale
- Oliver De Los Santos - Louie Warrington
- Oliver De Los Santos - Louie
- Marco Sinigaglia - Tony Palladino
- Blessing Mokgohloa - Matthias Lund
- Jing Xuan Chan - Detective Brookes
- Deborah An - Courier
- Sara Wiseman - Tanya Reed
- Patrick Shearer - Max Zoric
- Joel Pierce - Customs Official
- Ben Knight - Cade - Senior Wharfie
- Frank Magree - Bennett - Yard Manager
- Matt Day - Dr. Samuel Bramson
- Marika Marosszeky - Desk Sergeant
- Nikhil Singh - Scam Tech
- Deborah Glover
- Tracey Robertson
- Nathan Mayfield
- Leigh McGrath
- Sally Riley
- Nathan Lloyd
- Matteo Zingales
Matt Day hace el papel de Dr. Samuel Bramson.
Chris Haywood hace el papel de Connelly.
Ioan Gruffudd interpreta a Dr. Daniel Harrow en la serie.
Jolene Anderson interpreta a Dr. Grace Molyneux en la serie.
Darren Gilshenan interpreta a Dr. Lyle Fairley en la serie.
Damien Garvey hace el papel de Bryan Nichols.
Ella Newton interpreta a Fern Harrow en la serie.
Hunter Page-Lochard hace el papel de Callan Prowd.
Faustina Agolley interpreta a Edwina Gharam en la serie.
Miriama Smith interpreta a Renae Warrington en la serie.
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