- Bryce Lorenzo - Hailey
- Bryce Lorenzo - Hailey Hansen
- Lily Du - Colleen
- Ruth Righi - Wiseman #1
- Debi Mazar - Isabella Scaramucci
- Paul Wight - Big Pink
- Ashlie Atkinson - Ace
- Antonia Rey - Assunta
- Donnetta Lavinia Grays - Hubble
- Bob Turton - Scoot
- Ratnesh Dubey - Dr. Reddy
- Thedra Porter - Recovering Addict #1
- Andrew Kaempfer - Trotsky
- Hannah Hodson - Prostitute
- Hannah Hodson - Angel
- Magdalena Borlando - Intern
- Kyle Klaus - Brad
- Erik McKay - Prison Guard
- Garrett Richmond - Cheap Suit
- Mami Kimura - Nurse
- Kristoffe Brodeur - Russian Prison Gang Member
- Kimmy Suzuki - Asian Nun
- Tiffany Denise Hobbs - Nurse
- Catherine Ashmore Bradley - Penny Baker
- Joseph D. Reitman - Very Bad Santa (as Joseph Reitman)
- Gus Halper - Michael "Mikey" Scaramucci
- Laura Poe - Jessica McCarthy
- Brendan Burke - Terrance
- Sam Wolf - Florian Scaramucci
- Joe Perrino - Pal Scaramucci
- Carly Roland - Gala Scaramucci
- Sawandi Wilson - Cop 2
- Dante Pereira-Olson - Gerry Scaramucci
- Lars Engstrom - Police Officer
- Anthony Vaughn Merchant - Paramedic 1
- Sebastian Chacon - Paramedic 2
- Glenn Wein - Prawn Man
- Matt Giroveanu - Hospital Security Cop
- Michael Maize - Le Dic
- Lexia Hayden - Angel
- Gayle Pillsbury
- Blair Mowat
- Guillaume Roussel
Christopher Meloni interpreta a Nick Sax en la serie.
Ritchie Coster interpreta a Francisco Scaramucci / Orcus en la serie.
Lili Mirojnick interpreta a Det. Meredith McCarthy en la serie.
Medina Senghore interpreta a Amanda Hansen en la serie.
Patrick Fischler hace el papel de Smoothie.
Christopher Fitzgerald interpreta a Louis "Sonny Shine" J. Sheinberg en la serie.
Bryce Lorenzo interpreta a Hailey en la serie.
Patton Oswalt interpreta a Happy (voice) en la serie.
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