- Alec Mapa - Adam Benet
- James 'Jimmy Jam' Harris III - Himself
- Adrianne Curry - Roberta
- Joel Brooks - Dr. Bruckner
- Laz Alonso - Derek
- Jason George - Miles
- Gabby Soleil - Young Dee Dee
- Yvette Nicole Brown - Ceci
- Jonathan Goldstein - Photographer
- Susie Castillo - Shaunie
- Lonette McKee - Tonya
- Yancey Arias - Carter Del Toro
- Amy Hunter - Tangerine
- Mel Jackson - Roland
- Darion Basco - D-Lyrious
- Kel Mitchell - Marlon
- Alan Thicke - Gavin Storm
- Terrence 'T.C.' Carson - Kyle Barker
- Nicole Randall Johnson - Reporter
- Louie Anderson - Louie
- Roxanne Beckford - Angela
- Blair Underwood - Himself
- Ted Lange - Repairman
- Anthony Montgomery - Ron Brown
- T.J. Thyne - Casey
- Julius Carry - Earl
- Shaun Robinson - Lingerie Clerk
- Richard Lawson - Ben
- Dorothy Lucey - Vicki
- Dayna Devon - Dayna
- Shemar Moore - Amani Love
- Niecy Nash-Betts - Carla
- Giancarlo Esposito - Darrell Washington
- Daisy Fuentes - Nina
- Clifton Davis - Pastor David Adams
- Martin Mull - Bob Tyrell
- Billy Dee Williams - Otis 'Omar Funk' Wright
- Diahann Carroll - Grandma Ruth Thorne
- Nicole Pulliam - Girl
- James Lesure - Brian LeFine
- Nicole Scherzinger - Jasmine
- DMX - Himself
- Robert Pine - Senator Scranton
- Tyson Beckford - Sexy Guy
- Sugar Ray Leonard - Doctor
- Debbie Matenopoulos - Joanna
- Mark Steines - Craig
- Ace Young - Himself
- Jazzmun - Clayvon
- Taraji P. Henson - Gabrielle
- Coby Bell - Glen
- Tangi Miller - Alana Mitchell
- Rodney Peete - Himself
- Christina Chambers - Jenna
- Jamie Denbo - Cindy
- Rochelle Aytes - Yolanda
- Rowena King - Camille
- Paige Peterson - Dalis Temple
- Joey Lawrence - Brett Mahoney
- Rupert Boneham - Paul
- Bill Bellamy - James Lewis
- Tyler Florence - Himself
- Eugene Byrd - Derek
- Wayne Wilderson - Ernie
- J.P. Manoux - Erik
- Eric Benet - Reece Wilcox
- Erika Alexander - Maxine Shaw
- Quddus - Himself
- Verne Troyer - Reggie
- Terrell Tilford - Julian Houston
- Ryan Michelle Bathe - Aurora
- Natalie Garza - Randi
- Shari Headley - Barbara
- Roz Ryan - Josephine Baylor
- Merlin Santana - Dante Aldente
- Melanie Chartoff - Bridget
- Denyce Lawton - Beautiful Girl
- Jazsmin Lewis - Karen
- Ethan Phillips - Dr. Adelman
- Chris Spencer - Darrell
- Albert Hall - Justice Harrison Todd
- Carolyn Hennesy - Mrs. Scranton
- Jamia Simone Nash - Jamia
- Lamman Rucker - Chase
- Steven Eckholdt - Gus Mason
- Marcus Patrick - Vince Clark
- Louis Gossett Jr. - Ray Willis
- Kiko Ellsworth - Clay
- Josh Meyers - Big Fat Slim Jim
- MC Lyte - Kai Owens
- Ambrosia Kelley - Molly Del Toro
- Nicole Lyn - Stephanie Seymour
- Ginuwine - R.J. Jackson
- Wren T. Brown - Professor Marvin Wilkins
- Alexander Aquino - Delivery Guy
- Danielle Nicolet - Sammi
- Berlinda Tolbert - Denise
- Antonio Sabàto, Jr. - Carlo
- Lindsey Stoddart - Kendra
- Nick Stabile - Nick Tyrell
- Meredith Baxter - Joan Tyrell
- Marianela Pereyra - Pretty Woman
- Tatyana Ali - Olivia
- Tyrese Gibson - Himself
- Malinda Williams - Myra
- Carla Jimenez - Jackie
- Whitney Cummings - Woman
- Mageina Tovah - Ginny
- Michelle Williams - Naomi Dawson
- Assaf Cohen - Matt
- Aaron D. Spears - Hamilton Brooks
- Sarah Lancaster - Merce
- Penny Bae Bridges - Young Mona
- Greg Cromer - Hal
- Desmond Askew - Ian
- Nicole Garza - Rita
- Scott Halberstadt - Manager
- Daphnée Duplaix Samuel - Geneva
- Estelle Harris - Grandma Sophie
- Jaleel White - Hershel
- Suzy Nakamura - Tina
- Sunil Malhotra - Ellis
- Michael McLafferty - Kevin
- Loretta Devine - Erika Duke
- Mekia Cox - Alicia
- Jose Canseco - Himself
- Jason Olive - Jamal
- Shauna Sand - Tammi
- Al Whiting - Graduate
- Russell W. Howard - Chris
- Lisa Arch - Dr. Swenson
- Tamyra Gray - Zora Kane
- Cris Judd - Marqui
- Keenyah Hill - Amy
- Lamont Johnson - Rufus
- Lisa Arturo - Saleslady
- Shirley Prestia - Grace
- Eric Dearborn - Greg
- Hailee Dickens - Popular Girl
- Jennia Fredrique - Delilah
- Aydiee Vaughn - Nurse
- Arreale Davis - Annie Peete
- Ian Virgo - Temple
- Jacory Gums - Buzzy G
- Stacy Francis - Regina
- Matthew Rimmer - Waiter
- Johari Johnson - Tiffany
- Marquita Terry - Gina
- Kente Scott - Channing
- Donn Swaby - Jason
- Linda Kee - Nurse
- Gichi Gamba - Policeman
- Elena Varela - Pretty Nurse
- Obi Ndefo - Marcus
- Amanda Young - Woman
- Todd Sherry - George
- Summer Walters - Hilary
- Paul Vaillancourt - Surly Customer
- Charlie Maher - Mike
- Kathy Griffin - Dr. Morgan
- Evan Marriott - Warner
- Nigel Thatch - Keno
- Kym Hoy - Tricia
- Chad Gabriel - Eric
- Gary 'G. Thang' Johnson - Rufus
- Keith D. Robinson - Neil Crawford
- Dondré Whitfield - Brendan
- Teck Holmes - Junebug
- Patrick Brennan - Oscar
- Faith Evans - Asia
- Sally Brooks - Vicki
- Christina Williams - Spirit #1
- Jim Blanchette - Big Guy
- Kendra Waldman - Marsha
- Zach Robinson - Zach
- Vince Green - Maceo
- Judy Prescott - Ruth
- Terry Lewis - Himself
- Ping Wu - Curtis
- Chris Boyd - Dave
- Kareem Abdul-Jabbar II - Dwight Mitchell
- Corey Holcomb - Chauncey
- Janell Inez - Carla
- Steven Hill - Michael
- Yvette Lee Bowser
Kathy Griffin hace el papel de Dr. Morgan.
Eugene Byrd interpreta a Derek en la serie.
Giancarlo Esposito interpreta a Darrell Washington en la serie.
Billy Dee Williams hace el papel de Otis 'Omar Funk' Wright.
Rachel True interpreta a Mona Rose Thorne en la serie.
Essence Atkins interpreta a Dee Dee Thorne en la serie.
Telma Hopkins hace el papel de Phyllis Thorne.
Valarie Pettiford interpreta a Big Dee Dee Thorne en la serie.
Chico Benymon interpreta a Andre Spencer Williams en la serie.
Alec Mapa hace el papel de Adam Benet.
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