- Clayton Prince - Dowd
- Billy Lush - Lucas Atherton
- Tawny Cypress - Anna Rowe
- David Bailey - Dr. Bellamy
- John Heard - Paul 'Webster' Ballinger
- James Badge Dale - Billy Ryan
- Darnell Williams - Brian Anderson
- Brad Beyer - Daren Adams
- Marisa Ryan - Melissa
- Michael Gaston - Claymore
- James Eckhouse - Anthony Lewis Sparks
- Nick Mancuso - Vahan Badakian
- John Benjamin Hickey - Martin Shane
- Martha Plimpton - Louise O'Connor
- Titus Welliver - Zachary
- Jason Antoon - Henry Nibs
- Brian Wilson - Raymond Henley
- Jane Krakowski - Mrs. Smith
- Kali Rocha - Joyce
- Michelle Monaghan - Stacy Kumble
- Anthony Chisholm - Big Elwood
- Peter Hermann - Mark Vincenzo
- Matt Servitto - Marty Glavin
- Fisher Stevens - Donnie Franco
- Jennifer Esposito - Abby
- Adam LeFevre - Chuck Bynum
- Jonathan Walker - Phil White
- Hannah Pilkes - Quinn
- Matt Czuchry - Jamie Farrel
- Donna Murphy - Heather Olshansky
- Jacqueline Torres - Liz Garza
- Joanna Rhinehart - Deborah Washington
- Joanna Rhinehart - Janelle Washington
- Paul Adelstein - Aldo Rossi
- Bebe Neuwirth - Faith O'Connor
- Gregg Edelman - Ryan Ambrose
- Cindy Katz - Bettina Corwin
- Ukee Washington - Reporter
- Mark Margolis - Nicolai Zosimov
- Lindsay Crouse - Beth Kulvicki
- Keith Moyer - Court House Visitor / NA Group Member
- Keith Moyer - Scary Cab Fare
- Keith Moyer - Drug Dealer (uncredited)
- Keith Moyer - Death Penalty Protestor (uncredited)
- Brian Smiar - Bill Olshansky
- Jason Loftus - Cop
- Lee Tergesen - Carl Ginley
- Conor O'Farrell - Paul Goodman
- David Patrick Kelly - Eddie O'Daniel
- Hayden Saunier - Mrs. Kumble
- Abigail Breslin - Kayla Adams
- Colleen Clinton - Jeanine Adams
- Laura Ekstrand - Renee Anderson
- Idris Elba - Mac Boone
- Oksana Lada - Katrina Nibs
- Joseph Siravo - Captain Dalton
- Moira Kelly - Vanessa Griffin
- Jason Ritter - Buddy Griffin
- Craig muMs Grant - Omar
- John Dossett - Jack Shannon
- Damon Gupton - Mark Simmons
- Jacqueline Anderson - Marie
- Michael Hayden - Nick Bennett
- Diane Neal - Patricia Bennet
- Peter Jay Fernandez - Nunez
- John Jezior - Andy
- Stink Fisher - Chris
- Sean Oliver - Officer Nelson
- Brian T. Delaney - Troy Pappas
- Patrick Garner - Money Man
- Michael Jacoby - Johnny Texas
- David Fonteno - Terrence Giles
- Meghan Wolf - Jody Lincoln
- Kevin Corrigan - Brad Pierson
- Harry O'Reilly - U.S. Marshal Wyatt
- Jennifer Westfeldt - Emily Carson
- Ken Jennings - Little Harry
- Ken Jennings - Harry
- Natacha Roi - Patty
- Jamie Goodwin - Doug Fulton
- Robert Kelly - Jim Cooper
- Jennifer Mudge - Eva Beallo
- David L. King - Wayne Gondry
- Nadia Axakowsky - Nancy Campbell
- Jeff Farber - Paul Dockerty
- Matte Osian - Duke Badakian
- Yusuf Gatewood - Truby
- Mark Indelicato - Berge
- Gary Cole - Johnny Scanlon
- Chad Lowe - Jimmy Scanlon
- Kevin O'Rourke - Terry
- Deirdre Lewis - Dr. Baines
- Viola Davis - Stevie Morgan
- Robert Clohessy - Jack Tully
- Shannon Burkett - Jody Hawthorn
- Michael Mastro - Sean Loring
- Patrick McDade - Lonny Hawthorn
- Robert Petkoff - Bill Burke
- Henry Strozier - Bishop Long
- Stephanie Ittleson - Jeannie
- John Seidman - Marty Handler
- Tim Moyer - Ethan Morris
- Donovan Hagins - Hospital Guard
- Richard Domeier - Bob Robbins
- Will Bozarth - Frederick Morton
- Adam Grupper - Jenkins
- Susan Pellegrino - Mrs. Morton
- Jerry Walsh - Barry Perfetta
- Alexandra Lydon - Julie Reed
- Michael McKenzie - Pastor Frank
- Alfred Sauchelli, Jr. - Ted Bianchi
- Ritchie Coster - Nick Trepov
- Sophina Brown - Tammi Anderson
- Thomas Ryan - Sean Reilly
- Tony Woods - Skeeter Davis
- Lou Sumrall - Zeke Shepard
- Jenn Korbee - Zoe
- Anthony Lawton - Brody
- Bruce Kirkpatrick - Cop
- Chuck Cooper - Hayden
- James McCaffrey - Coslow
- James Rebhorn - Richard Farrell
- Richard Barlow - Greene
- Patrick Dizney - Jenner
- Jennifer Massey - Suburban Woman
- Sterling K. Brown - Rasheed Morgan
- Ryan Sands - Wendell Edison
- David Boller - Rhodes
- Thomas J. McCarthy - Kuehn
- Rick Breitenfeld - Man
- David Harbour - Christopher Clark
- Christopher Orr - Brian Lowe
- David Vadim - Manny
- Francie Swift - Jennifer Holt
- Heather Mazur - Rina Lowe
- Ted Koch - Erik Lincoln
- Jason Kolotouros - Detective Madrid
- William R. Johnson - Detective Dennison
- Ken Arnold - Shane Newhart
- Charlie Fersko - Lou Casey
- Susan Wilder - Doctor Alpern
- Kim Simms Thomas - Secretary
- Angel Oquendo - Security Guard
- J.D. Jackson - Skeeter D
- Ryan Ward - Eric
- Myk Watford - Bert
- Kate Kearney-Patch - Jane
- Desiree Marie Velez - Dr. Ramirez
- Chad L. Coleman - Lafonso
- Jess Weixler - Martha Skulnick
- Adam Rothenberg - Greg
- Leon - Ulysses Sims
- Julito McCullum - Cal Milton
- Kelly Hutchinson - Helen Olshansky
- Shane McRae - Chris Olshansky
- Christina Chang - Cate Tann
- Vince Cupone - Sal DiMeo
- Eric Thal - Danny Jannik
- Clark Carmichael - Court Clerk
- Elizabeth Reaser - Elaine Jones
- Thomas Carter
- David Shore
- Gavin Polone
Chuck Cooper interpreta a Hayden en la serie.
Mark Margolis hace el papel de Nicolai Zosimov.
David Patrick Kelly interpreta a Eddie O'Daniel en la serie.
Yusuf Gatewood hace el papel de Truby.
Robert Clohessy interpreta a Jack Tully en la serie.
David Morse hace el papel de Mike Olshansky.
Andre Braugher hace el papel de Marcellus Washington.
Capítulo disponible en las siguientes plataformas:
