- Lucinda Raikes - Karen Ball
- Julian Rhind-Tutt - Mac
- Karl Theobald - Martin Dear
- Sarah Alexander - Angela Hunter
- Paterson Joseph - Lyndon
- Stephen Merchant - Lab Technicianian
- Rosie Cavaliero - Teacher
- Sally Phillips - Holly Hawkes
- Oliver Milburn - Liam
- Daisy Haggard - Emmy
- Pip Torrens - Neurosurgeon
- Nick Frost - Just a Man
- Richard Katz - Campervan Couple
- Kevin Eldon - Scissors Bentley
- John Oliver - Car Salesman
- Sarah Hadland - Nurse
- Di Botcher - Catering Manager
- Tom Goodman-Hill - Politician
- Steve Oram - Security Guard (uncredited)
- Manjinder Virk - Theatre Nurse
- Saskia Wickham - Chaplain
- Keir Charles - Oliver
- Jane Whittenshaw - Food Server
- Fay Rusling - Nurse
- Kevin Hudson - Doctor
- Roger Frost - Dead Wife Man
- Gemma Catlin - Shop Assistant
- Gary Howe - Lodger
- Rosie Mahoney - 6th Former
- Kristy Bruce - 6th Former
- Michael Simkins - Judge
- Ramon Woolfe - Deaf Signer
- Nathaniel Gleed - Josh
- Jay Byrd - Cleaner
- Matthew Ashforde - Terry
- Oriane Messina - Lodger
- Oriane Messina - Prostitute
- Oriane Messina - Nurse
- Benoît Lambert - Waiter
- Rachel Freck - Mum
- Billy Sneddon - Homeless Person
- Vicki Pepperdine - Neighbour
- Michael Gould - Neighbour
- Glynis Brooks - Ward Sister
- Ash Varrez - Professor Mancoo
- Diveen Henry - Nurse
- Paul Bazely - Anaesthetist
- Jane Cameron - Nurse
- Rebecca Clow - Nurse
- Doreen Ingleton - Nurse
- Alison Pargeter - Nurse
- Chetna Pandya - Nurse
- Darren Boyd - Jake
- Robert Harley - C.E.O.
- Robin Weaver - Poetry Woman
- Rosie Alvarez - Chinese Girl
- Li-Leng Au - Chinese Girl
- Peter McDonald - Director
- Simon London - Presenter
- Chizzy Akudolu - Car Park Attendant
- Kim Benson - Laundry Op
- Roderic Culver - Anaesthetist
- Justin McCarron - Art Teacher
- Danny Nussbaum - Skinhead
- Ed Petrie - Social Worker
- Geff Francis - Pimp
- Jennifer Hennessy - Suzie
- Simon Ludders - Detective
- Mick Walter - Joanna's Cousin
- Ron Webster - Donald Twat
- Sue Elliott-Nichols - Teenager's Mum
- Preeya Kalidas - Newsagent
- Simon Nagra - Indian Waiter
- Jonah Russell - Shoe Shop Assistant
- Adam Tandy - Patient
- Richard Freeman - Vicar
- Cavan Clerkin - Garage attendant
- Spencer McLaren - Jonny
- Simon Kunz - Replacement radiologist
- Yvonne D'Alpra - Shopkeeper
- Derren Litten - Traffic cop
- Jeremy Sheffield - Jeremy
- Victoria Pile
- Peter Fincham
Tamsin Greig hace el papel de Caroline Todd.
Stephen Mangan interpreta a Guy Secretan en la serie.
Sarah Alexander interpreta a Angela Hunter en la serie.
Sally Bretton interpreta a Kim Alabaster en la serie.
Karl Theobald interpreta a Martin Dear en la serie.
Pippa Haywood hace el papel de Joanna Clore.
Stephen Merchant interpreta a Lab Technicianian en la serie.
Mark Heap hace el papel de Alan Statham.
Michelle Gomez interpreta a Sue White en la serie.
Julian Rhind-Tutt interpreta a Mac en la serie.
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