- Michael Copon - Shane
- Geoffrey Arend - Egyptian Joe
- Kevin Kilner - Mr. Chambers
- Travis Van Winkle - Travis
- AnnaLynne McCord - Destiny/Patty
- Ryan Sypek - Ryan Prince
- Robert Hoffman - Patrick Chambers
- Lisa Wilhoit - Tina
- Senta Moses - Lizzi
- Lea Thompson - April
- Jesse Williams - Drew Collins
- Charisma Carpenter - Tegan Walker
- Devon Werkheiser - Peter Parkes
- Thomas Calabro - Senator Ken Logan
- Yani Gellman - Pete
- Michael Rady - Max Tyler
- Lisa K. Wyatt - Helga Von Lempke
- Bobby Hosea - Roger Owens
- Helen Slater - Dr. Magda Stephanopoulos
- DeVaughn Nixon - Pookie
- Kathryn Harrold - Mrs. Chambers
- Max Greenfield - Michael
- Ken Marino - Camp Leader
- Daphne Bloomer - Advisor Jacqueline Singer
- Danny Pudi - Sanjay
- Arielle Vandenberg - Lisa Lawson
- Olivia Munn - Lana
- Jonathan Silverman - Lasker Parkes
- Dan Castellaneta - Dr. Milton Hastings
- Marty McSorley - Himself
- Ann Cusack - Karen Cartwright
- Wendi McLendon-Covey - Connie
- Petrea Burchard - Gladys
- Gus Lynch - Party Photographer
- Dan Byrd - Kirk
- Carol Potter - Paula Baker
- Jerad Anderson - Jonah Perkins
- Andrew St. John - Nate Radcliffe
- Olesya Rulin - Abby
- Derek Mio - Wade Matthews
- Martha MacIsaac - Dana Stockwell
- Sam Page - Joel
- Eileen April Boylan - Betsy
- Alan Ruck - Dean Bowman
- John de Lancie - Himself
- Brandon G. Holley - Kappa Tau Active
- Jesse McCartney - Andy
- Martha Smith - Mary Beth
- Pamela Walworth - Tabitha
- Erin Cahill - Trish
- Jerry Lambert - Russell Cartwright
- Jamie Chung - Siena
- Aaron Hill - The Beaver
- Connie Ray - Norma
- Johanna Braddy - Jordan Reed
- Dave Franco - Gonzo
- Kelly Stables - Janette
- Tom McGowan - Fred
- John Rubinstein - Dr. Larsen
- Sophie Simpson - Mary-Elyse
- Jhoanna Flores - Libby
- Christopher Goodman - CIA Recruiter
- Zack Lively - Heath Anderson
- Jessica Lee Rose - Jen K
- Daniel Weaver - Ben Bennett
- Darlene Hunt - Rental car worker
- Adam Crosby - Pickle
- Steven Crowder - Jace
- Jessica Lowndes - Mandi
- Alanna Masterson - Alanna
- Loren Lester - Harvard Dean
- Courtney Ray Geigle - Pete
- Tarajia Morrell - Jill
- Mark Hapka - Jeff
- Kinsey McLean - Trip
- Kevin Kirkpatrick - Officer Huck
- Marisa Lauren - Brenda
- Alex Veadov - Professor Hebert
- Alex Loynaz - Ian
- Eric Artell - Tim
- Eric Artell - Mr. Psi Phi Pi
- Gregory Hoyt - Seth Lubineck
- Zoe Jarman - The Tour Guide
- Agnes Albright - Heather
- Tiya Sircar - Emma
- K.T. Tatara - Ted
- Blake Cooper Griffin - Condon Debney
- Anna Osceola - Robin Wylie
- Myra Cheney - Sarah Ting
- Brian Maillard - Jason
- J.R. Nutt - Brian
- Aynsley Bubbico - Laura
- Aynsley Bubbico - Natalie
- Brett Gipson - Greg
- Bobby Campo - Trent
- Samantha Figura - Andrea
- Drew Roy - Omega Chi Pledge
- Scott Rinker - Dr. Klein
- Lisa Fredrickson - Dr. Allesandri
- Mara LaFontaine - Mandi
- Scheana Marie Shay - Jenny
- Angelica May - Jess
- Maggie Contreras - Suzanne
- Michael Miranda - Toby Kwon
- Inger Tudor - Dr. Shapiro
- Eva Fisher - Ms. Brown
- Kendrick Sampson - Woodchuck
- Rebekah Brandes - Caesar
- Ryan Alvarez - Casca
- Peter Cellini - Brutus
- Quinn Sullivan - Regina
- Jodi Carol Harrison - Jeannie
- PaSean Wilson - Virgilia
- Tara Erica Moore - Tara
- Steffany Huckaby - Beth
- Ken Luckey - Vince
- Amy Gumenick - Reagan
- Trisha LaFache - Greta
- Nikki McKenzie - Holly
- Caitlin Custer - Vanessa
- Alyssa Diaz - Chrissy Snow
- Harry Shum Jr. - Vance
- Patty McCormack - Joan
- Kristen O'Meara - Sheila
- Cindy Chiu - Megan
- Andrew J. West - Fisher
- Damien Leake - Professor Sommerfield
- Janeane Garofalo - Professor Freeman
- Kristy Vaughan - Natalie
- Collette Wolfe - Kiki
- Norma Michaels - Mrs. Baker
- Henry Dittman - Sports Analyst
- Ryan Rottman - Jess
- Danièle Watts - Girl
- Candice King - Alice
- Jenna Bryant - Tracy
- Walter Williamson - Tiny
- Melanie MacQueen - Librarian
- Seema Lazar - Michele
- Italia Ricci - Delia
- Tom DeTrinis - Peter
- Rochelle Rudolph - Nicole
- Ross Gibby - Pastor Dan
- Ashli Haynes - Tara
- Leslie-Anne Panaligan - Whitney
- Drew Van Acker - Parker
- Mimi Cozzens - Doris McGovern
- Roberta Hanlen - Professor Belski
- Kristina Cohen Kruz - Sophia
- Matthew Patrick Davis - Brett
- Kylie Sparks - Nora
- Angie Simms - Jenna
- Marshall Porter - J.P.
- Nora Kirkpatrick - Katherine Parker
- Nora Kirkpatrick - Joel
- Chad Michael Collins - Tim
- Cristina Balmores - Heather
- Frank Drank - Viper
- Kristina Plisko - Melanie
- Arshad Aslam - Samir
- Kaiser Johnson - Jason
- Devin Crittenden - Anthony Hopkins
- Jordan Masterson - Dump Truck
- Steven Christopher Parker - Todd
- Irene Choi - Angie
- Krista Kalmus - Erica
- Hank Harris - Ryan Yarlbrough
- Adria Tennor - Professor Clarissa Hawn
- Judy Clement - Joanne Fletcher
- Warren Sweeney - Dr. Lundquist
- Jeff Witzke - David Fanning
- Grey Damon - Hunter
- Tony DeSean - Hasher
- Scott Lilly - Hasher
- Cory Blevins - Campaign Worker
- Andy Daly - Tom Hilgendorf
- Ele Keats - Margie Hilgendorf
- Tim Jo - Dewey
- Aimee Carrero - Sunny
- Jim Abele - Tobias
- Jessica Meraz - Eliana Hernandez
- Andrea Bogart - Faith Flowers
- Stephen Jared - Officer Nixon
- Alan Wells - Rob
- Chesaré Hardy - Samantha
- Andrea Harrison - Cindy
- Jill Basey - Miriam
- Greta Sesheta - Edna
- Heather Hegeman - Jolene
- Caitlin Thompson - Heather
- Josh Randall - Professor Simon Segal
- Armen Weitzman - Jim Carnes
- Becky Wu - Jan Carnes
- Stephanie Hunt - Molly
- Maggie Gwin - Joni
- Benton Jennings - Professor
- Matt Crabtree - Daniel Franklin
- Beth Crosby - Matilda Lawrence
- Floyd Van Buskirk - Carol
- Shelley Robertson - Professor Morreti
- Shelley Robertson - Hillary
- Taylor Groothuis - Hailey Segal
- Nick Jaine - Ziad
- Cathy Baron - Denise
- Dalton Leeb - Mr. Schmock
- Jessy Hodges - Hillary
- Luke Kleintank - Rylan
- Jamie Lea Willett - Tawny
- Tom Lenk - Tour Guide Smith
- Chris Sheffield - Omega Chi Pledge
- Melissa Johnston - Zeta Beta Zeta Girl (uncredited)
- Lloyd Segan
- Shawn Piller
Lea Thompson hace el papel de April.
Alan Ruck interpreta a Dean Bowman en la serie.
Dan Castellaneta interpreta a Dr. Milton Hastings en la serie.
Amber Stevens West interpreta a Ashleigh Howard en la serie.
Spencer Grammer interpreta a Casey Cartwright en la serie.
Clark Duke interpreta a Dale Kettlewell en la serie.
Dilshad Vadsaria interpreta a Rebecca Logan en la serie.
Jacob Zachar hace el papel de Rusty Cartwright.
Paul James hace el papel de Calvin Owens.
Scott Michael Foster hace el papel de Cappie.
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