- Glenn Close - Self - Host
- Harvey Keitel - Jerry
- Brad Garrett - Self
- Joe Grifasi - Cpl. Matson
- Laurence Olivier - Self
- Gary Sinise - Self
- George Murdock - Bud Loring
- Sally Field - Self
- Beverly D'Angelo - Self
- Larry Gates - Sir Oliver Surface
- Ethan Hawke - Self
- Antonio Banderas - Self
- Rob Lowe - Doctor Cukrowicz
- Kathleen Turner - Self
- Diane Lane - Charity Royall
- Frances McDormand - Self
- Jack Lemmon - Self
- Frances Conroy - Mrs. Gibbs
- James Stewart - Self
- Lee Remick - Phyllis Rogers Stone
- Peggy Ashcroft - Self
- Patrick McVey - Haggerty
- Whoopi Goldberg - Self
- Eve Arden - Queen of Hearts
- Dianne Wiest - Elizabeth Gertrude Stern
- Marcia Gay Harden - Self
- Anna Thomson - Carter
- Ian Richardson - Bishop of Motopo
- Michelle Pfeiffer - Natica Jackson
- Audrey Hepburn - Self - Host
- George Martin - Boss Mangan
- Martin Balsam - Jack
- Mickey Rooney - Self
- Robert Foxworth - Matt Stanton
- Matthew Broderick - Self
- Don Fellows - Professor Pilbeam
- Jason Robards - Grandpa Martin Vanderhof
- Tom Hulce - young Frank
- Joan Cusack - Anne
- Christine Ebersole - Self
- Treat Williams - Self
- Jeffrey Jones - Sgt. Wilson
- Barbara Bryne - Mrs. Candour
- Richard Attenborough - Self
- Philip Stone - Father Leopoldo
- Samuel L. Jackson - Self
- Hector Elizondo - Morris King
- Charles Durning - McMahon
- Clint Eastwood - Self
- Morgan Freeman - Messenger
- Daniel von Bargen - Wooldridge
- Eli Wallach - Self
- Susan Sarandon - Patsy Johnson
- Rosie Perez - Self
- James Keane - Mr. Ealer
- Olympia Dukakis - Pauline
- Jeff Bridges - Michael Loomis
- Angie Dickinson - Self
- Bob Dylan - Self
- Stephen Collins - Morton Fullerton
- Richard Dreyfuss - Self
- Brian Cox - Self
- William Hurt - Walter
- Ed Harris - Self
- Kevin Costner - Self
- Barnard Hughes - Jim
- Ray Walston - Self
- Kirk Browning
- Sharon Mullally
- John J. Desmond
- Ross MacGibbon
- Kathy Dougherty
- Todd Decker
- David Wild
- Ring Lardner
- Richard Bean
- William Shakespeare
- Conor McPherson
- Valerie Thomas
- Bob Telson
Glenn Close interpreta a Self - Host en la serie.
Harvey Keitel hace el papel de Jerry.
Brad Garrett interpreta a Self en la serie.
Joe Grifasi interpreta a Cpl. Matson en la serie.
Laurence Olivier hace el papel de Self.
Gary Sinise interpreta a Self en la serie.
George Murdock interpreta a Bud Loring en la serie.
Sally Field interpreta a Self en la serie.
Beverly D'Angelo interpreta a Self en la serie.
Larry Gates interpreta a Sir Oliver Surface en la serie.
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