- Jason Ralph - William
- Phil Abrams - Dr. Weintraub
- Stacey Farber - Jo
- Aris Alvarado - Joaquin
- Ray Auxias - Ted
- Alexis Krause - Steph
- Amy Aquino - Dana
- Jessica Gardner - Karen
- Ben Seaward - Kyle
- Richard Fancy - Sam
- John Shartzer - Don
- Siobhan Dillon - Kayla
- Sofia Gonzalez - Other Chelsea
- Shaw Jones - Event Photographer
- Ayden Mayeri - Skye
- Brooke D'Orsay - Chelsea
- Elliott Gould - Dr. Rogers
- Mandell Maughan - Cassidy
- Brittany Ishibashi - Erica
- Jeff Elam - Greg
- Roy Jenkins - Ron
- Angelique Cabral - Liz
- Erin Pineda - Erin
- Debbie Allen - Dorothy
- Rory O'Malley - Jordy the Server
- Chad Jamian Williams - Bert the Nervous Chef
- Greta Sesheta - Judy
- Mary Steenburgen - Miriam
- Michael McKean - Jack
- Orson Bean - Bruno
- Ernie Hudson - Jacob
- Casey Wilson - Taneth
- Dhruv Bali - Massage Therapist
- Charlie Dell - Sidney
- Daheli Hall - Wenda
- Lee Lawrence - Partygoer #1
- Bianca Lopez - Bridget
- Lee Weaver - Mel
- Vella Lovell - Nicole
- Christine Woods - Jessica
- Dan Warner - Officer Davidson
- Jessica B. Wellington - Viv
- Keith Powell - Jordan
- Barbara Corcoran - Barbara Corcoran
- Mark Cuban - Mark Cuban
- Lori Greiner - Lori Greiner
- Kevin O'Leary - Kevin O'Leary
- Lindsey Kraft - Allison
- Lindsey Kraft - Allison Giampietro-Smikowitz
- Bo Barrett - Cool Guy
- Yeniffer Behrens - Sofia
- Doug Cox - Eric
- Darius De La Cruz - Nico
- Chrisanne Eastwood - Stage Manager
- Andrew Hawtrey - Man in Line
- Josh Cooke - Dan Penbraith
- Josh Cooke - Dan
- Alex Ruiz - Miguel
- Tim Bagley - Peter
- Peter Cambor - Barry
- Kasey Mahaffy - Brett
- Millicent Martin - Joan-Margaret
- Michael Charles Roman - Adam
- Engelbert Humperdinck - Engelbert
- Carrie Preston - Krystle
- Raegan Revord - Little Girl
- Romika Annabell - Margie
- Cora Vander Broek - Agent Karen
- Cora Vander Broek - Agent Karen Fischer
- Kenny Loggins - Self
- Peter Gallagher - Nick Skolka
- Ed Asner - Howard Jay
- Marsha Mason - Arlene
- Jack Plotnick - Paul
- Dolly Parton - Agnes
- Jack Doke - Little Boy
- John Ross Bowie - Fred
- Mary Sohn - Ms. Alexander
- Artemis Pebdani - Madame Elsbeth
- Noen Perez - Spelling Bee Boy #2
- Debi Bradshaw - Woman
- Kale Clauson - Clerk
- Mary Linda Phillips - Daphne
- Dale Waddington - Middle-aged Woman
- Geoff Stults - Mitch
- Joe Morton - Jason
- Mary Kay Place - Amanda
- Michael Scott Allen - Waiter
- Cole Michaels - Macklin
- Romel de Silva - Man
- Brittany Finamore - Pretty Customer
- Christine Lahti - Lydia Foster
- Richard Azurdia - Tito
- Jeff Doucette - Homer
- Peter MacKenzie - Peter Warren
- Timothy V. Murphy - Byron
- Jill Basey - Sally
- Fawn Irish - Sally's Daughter
- Richard Voigts - Retired Partner
- Corbin Bernsen - Dr. Paul Mason
- A.J. Castro - Technician
- Julia Cho - Heather
- Mandy McMillian - ER Nurse
- Julian Sergi - Brian
- Jennifer Weston - Nurse
- John Balma - Eddie
- Brian Benben - Charles
- Butch Klein - Al
- Ryan Allan Young - Waiter
- Craig T. Nelson - Guy
- Nicholas D'Agosto - Dutch
- Barry Heins - Mike (voice)
- Madison Hu - Spelling Bee Girl
- Connor Rosen - Spelling Bee Boy
- Michael Keyes - Yachtitech
- Todd Grinnell - Stephen
- Michael Gross - Jeff
- Creed Bratton - Seth
- Ken Lerner - Elliott
- Sam Buchanan - Bartender
- Eric Deskin - Stu
- William Dennis Hunt - Nelson
- David L. King - Charlie
- Jamie Landau - Hipster Waiter
- David Lengel - Manager
- Bon Ogle - Homeless Guy
- Garrison Oliver Gross - Hipster
- Nora Dunn - Dr. Rossmore
- Adam Shapiro - Rabbi
- Christopher Carroll - Priest
- Stacie Greenwell - Administrative Nurse
- Orel De La Mota - Carlos
- Alison Martin - Judy
- Alison Martin - Judy Warren
- Philip Smithey - Orderly
- Nancy Lantis - Nurse
- Rita Moreno - Lucy Chambers
- Todd Giebenhain - Jerry
- Conchata Ferrell - Grandma Jean
- Jai Rodriguez - Jojo
- Willa Miel Pogue - Madison
- Hudson West - Macklin
- Roxy Wood - Ana Phylatic-Shock
- Edith Fields - Brenda
- Sam Elliott - Phil
- Robert Baker - Officer Leach
- Swoosie Kurtz - Janet
- Larry Dorf - Bart
- Japheth Gordon - Chorus Member
- Japheth Gordon - Partygoer #2
- Todd Sherry - Chorus Member
- Todd Sherry - Partygoer #3
- Suzanne Ford - Mary
- Warren Berlinger - Bob
- Casey Sander - Ray
- Michael Durrell - Sonny
- Mark Pinter - Jerry
- Briana Venskus - Billie
- Kimleigh Smith - Gina
- Charlet Chung - Charlotte
- Tim Scanlon - Farmhand
- Sarah Baker - Gretchen
- Jay Ellis - Dan
- John Getz - John
- David VIllar - Guy
- Amy Madigan - Elaine
- Paul Scheer - Kyle
- Craig Welzbacher - Dan
- Estelle Parsons - Babe
- Michelle Meredith - Cashier
- Herbert Russell - Abandoned Husband
- Irene White - Been-Here-Since-Last-Night
- Hank Chen - Employee
- Sean Spence - Workers' Comp
- Rae Gray - Officer Lacy Jones
- Kaiwi Lyman - Skipper
- Debbie Lee Carrington - Tina Marie
- Lucy Morningstar - Frankie's Niece
- Matt Cook - Derrick Flout
- Lilah Richcreek Estrada - Cecilia
- Marcia Ann Burrs - Fiona
- John Lavelle - Highsmith
- Mark Saul - Tim
- Vernee Watson-Johnson - Doreen
- Sheila Shaw - Carol
- Rebecca Wackler - Nan
- Rachel Winfree - Elizabeth
- Eugene Cordero - Officer Torres
- Matthew Glave - Officer Tuttle
- Lois Smith - Mrs. Hanson
- Damon Dayoub - Ryan
- Biff Wiff - The Duke
- Tiffany Daniels - Marla
- Chris Aquilino - Evan
- Emily Montague - Ryan's Wife
- Jess Nurse - Katie
- Wendie Malick - Mimi
- Alyson Reed - Maureen
- Megan Ferguson - Nadia
- Ronnie Steadman - Ronnie
- Christopher Gehrman - Barely Sober Guy
- Roger Bart - Steve Clarrington
- Kevin Chamberlin - Frank
- Joanne Baron - Cheryl
- J. Elaine Marcos - Donna
- Nathan Blaiwes - Calvin
- Ed Begley Jr. - Mark
- Natalie Morales - Melissa
- Michael Medico - Chorus Member
- David Agranov - Chorus Member
- Lynette DuPree - Megan
- Bechir Sylvain - Chuck
- Dickie Hearts - Young Man
- Lisa Kudrow - Sheree
- Mel Rodriguez - Officer Terry Velez
- Tom Beyer - Fred
- Fred Mancuso - Angriest Man in the World
- Sara Van Horn - Older Lady
- Dan Bucatinsky - Arnold
- Christopher Chen - Best Director
- Eva La Dare - Female Presenter
- Scott Evans - Oliver
- Stephnie Weir - Mindy
- Shurud Shanto - Postal Guy
- Sarah Kay Jolly - Young Teddie
- Talia Shire - Teddie
- Mark Atteberry - Scott
- Julie Cummings - Campus Guard
- Milt Kogan - Grumpy But Dapper
- Bella Shepard - Young Girl
- Mike Castle - Bobbie
- Judith Drake - Very Old Woman
- Jack Fisher - Robin
- Riley Jackson - Young Frankie
- Mallory Portnoy - Gwendolyn Blart
- Eli Santana - Hardware Store Customer
- Shaun Brown - Josh
- Diona Reasonover - Ann Reins
- John C. Moskoff - Reggie Dunlop
- Gus Lynch - Danny
- Julie Hagerty - Shirley
- Jessica St. Clair - Lauren
- Mindy Sterling - Sally
- Lorraine Toussaint - Rebecca
- Mark Deklin - Roy
- Bill Stevenson - Stamford
- Jeff Austin - Hank
- Lamont Johnson - Eddie
- Saul Preciado-Garcia - Luis, Store Patron
- Kay Cole - Chorus Member
- Jennie Kwan - Chorus Member
- Kenneth Mosley - Chorus Member
- Brian Jordan Alvarez - Willy
- Anjali Bhimani - Raha
- Crista Flanagan - Katie
- Brendan McCarthy - Norbert
- Kent Avenido - Security Guard
- RuPaul - Benjamin Le Day
- Adam Faison - Bob
- Caitlin Leahy - Melissa
- Nicole Richie - Kareena G
- Mike Eshaq - Worker
- Eddie Shin - Toby
- Lynn Adrianna - Job Applicant
- Robert Buscemi - Store Manager
- Stephanie Erb - Michelle
- Monica Garcia Pérez - Maya
- Devon Michaels - Job Applicant
- John Marshall Jones - Fitz
- Charles Kim - Ron Akamine
- Petey Gibson - Peg
- Kimberly Daugherty - Jill
- Nikhil Pai - Rashid
- Scott Parkin - Zipper-Snapper Employee
- Paul Rogan - Donald
- Phillipe Simon - Enzo
- Rose Abdoo - Audrey
- Jackson Pace - Luke
- Jennifer Rhodes - Cathleen
- Emily Heller - Carson
- Rod Britt - Male Senior
- Stephan Smith Collins - Claude
- Thomas Crawford - Guy
- Gwen Van Dam - Marie
- Lauren Glazier - Young Woman
- Reatha Grey - Female Senior
- Ozy Reigns - Brian B.
- Cameron Sanders - Nerdy Teen
- Paul Michael Glaser - Leo
- David Walton - Jess
- Christian Barillas - Erasmus
- Amanda Carlin - Rita
- John Asher - Todd
- Matt Cordova - Diner
- Karly Rothenberg - Renee
- Meagen Fay - Goldie
- Mark Harelik - Joe
- Sam McMurray - Vince
- Ginger Gonzaga - Erin
- Edward Hibbert - Laramie
- Horace Dodd - Bouncer
- Michael J. Marchak - Young Gay Clubber
- Ryan Salazar - Matthew
- Michael-Leon Wooley - Wil
- Priyom Haider - Cute Gay Clubber
- Merrin Dungey - Elena
- Albert Kuo - Delivery Man
- Toby Grey - Boy
- Paul Tigue - Rabbi Sun Bear
- George Hamilton - Jack
- John Hoffman
Elliott Gould hace el papel de Dr. Rogers.
Orson Bean interpreta a Bruno en la serie.
Mary Steenburgen interpreta a Miriam en la serie.
Lee Weaver hace el papel de Mel.
Jane Fonda interpreta a Grace Hanson en la serie.
Lily Tomlin interpreta a Frankie Bergstein en la serie.
Martin Sheen hace el papel de Robert Hanson.
Sam Waterston interpreta a Sol Bergstein en la serie.
June Diane Raphael interpreta a Brianna Hanson en la serie.
Ethan Embry interpreta a Coyote Bergstein en la serie.
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