- Zabryna Guevara - Sarah Essen
- Jessica Lucas - Tabitha Galavan
- Jada Pinkett Smith - Fish Mooney
- Morena Baccarin - Leslie Thompkins
- Morena Baccarin - Dr. Leslie "Lee" Thompkins
- Frank Whaley - Doug
- James Frain - Theo Galavan / Azrael
- James Frain - Theo Galavan
- Lili Taylor - Patti
- David Zayas - Sal Maroni
- James Colby - Lt. Bill Cranston
- Jerry Dixon - Mr Thatch
- Jerry Dixon - Mr. Thatch
- Dan Bakkedahl - Davis Lamond
- Hakeem Kae-Kazim - Richard Gladwell
- Andrew Stewart-Jones - Crispus Allen
- Daniel Stewart Sherman - Mario Pepper
- Michael Kostroff - Officer Tannenbaum
- Clare Foley - Ivy Pepper
- Victor Cruz - Desk Sergeant
- Jon Beavers - Comedian
- Wayne Duvall - Morry Quillan
- Joe Starr - Arbogast
- Clark Middleton - Jimmy
- Jack Koenig - Ronald Danzer
- Joseph Latimore - Detective
- Carol Kane - Gertrude Kapelput
- Kim Director - Lacey White
- Susan Misner - Dr. Marks
- Danny Mastrogiorgio - Frankie Carbone
- Brad Calcaterra - Minks
- Daniel London - Stan Potolsky
- Evander Duck Jr. - Councilman Ron Jenkins
- Birkett Turton - Benny
- Drew Powell - Butch Gilzean
- Drew Powell - Solomon Grundy
- Lucille Sharp - Singer
- Genevieve Hudson-Price - Charmagne
- Peter Maloney - Isaac Steiner
- Sharon Washington - Molly Mathis
- Jeremy Davidson - Nikolai
- Margaret Colin - Taylor Reece
- Christopher James Baker - Raymond Earl / The Goat
- Makenzie Leigh - Liza
- Brian O'Neill - Robert Hastings
- Nicholas D'Agosto - Harvey Dent
- Leslie Odom Jr. - Ian Hargrove
- Luke Forbes - John Hargrove
- Todd Stashwick - Richard Sionis / The Mask
- Frank Deal - Dr. Felton
- Al Sapienza - Dick Lovecraft
- Steve Cirbus - Gregor Kasyanov
- Orlagh Cassidy - Mrs. Lawson
- Lesley-Ann Brandt - Larissa Diaz
- Devin Harjes - Clyde
- John Enos III - Saviano
- Niko Nicotera - Derek Delaware
- Christopher Heyerdahl - Jack Gruber
- Peter Scolari - Commissioner Loeb
- Caroline Lagerfelt - Mrs. Kean
- Charlie Tahan - Jonathan Crane / Scarecrow
- Julian Sands - Gerald Crane
- Robert Gorrie - John Grayson
- David O'Hara - Reggie Payne
- Milo Ventimiglia - Jason Lennon / The Ogre
- Dash Mihok - Detective Arnold Flass
- Willa Fitzgerald - Grace Fairchild
- Dustin Ybarra - Robert Greenwood
- Will Brill - Arnold Dobkins
- Stink Fisher - Aaron Helzinger
- Mark Margolis - Paul Cicero
- Norm Lewis - Deputy Mayor Harrison Kane
- Michael Potts - Sid Bunderslaw
- Kaipo Schwab - Gus
- Jeannine Kaspar - Penny
- Mattea Conforti - Little Girl
- Raúl Castillo - Eduardo Flamingo
- Michelle Gomez - The Lady
- Larry Pine - Mayor Burke
- Ilana Becker - Myrtle Jenkins
- Crystal Reed - Sofia Falcone
- Damian Young - Warden Reed
- Marina Benedict - Cherry
- Michael Cerveris - Professor Pyg
- Camila Perez - Firefly
- Aidan Fiske - Crying Boy
- Chris Perfetti - Cosmo Krank
- Steven Hauck - Headmaster
- John Treacy Egan - Zachary Trumble
- Christian Rozakis - Jongleur
- Yurie Collins - Girl Tuffie
- Natalie Alyn Lind - Silver St. Cloud
- Saundra Santiago - Janice Caulfield
- Danny Johnson - Gus Freeman
- Noah Robbins - Evan Pike
- Leo Fitzpatrick - Joe Pike
- Ari McKay Wilford - Cale Pike
- Lucas Salvagno - Sal Martinez
- Paul Reubens - Elijah Van Dahl
- Jonathan Rentler - Carl
- John Garrett Greer - Businessman
- Stephen James Anthony - Donnie
- Jinn S. Kim - Shop Owner
- Christopher Convery - Martin
- Marie Smalley - Falcone Family Member (uncredited)
- Paul Pilcz - Sonny Gilzean
- Giuseppe Ardizzone - Gabe Thug #2 (uncredited)
- Leslie Hendrix - Kathryn
- Alexander Siddig - Ra's al Ghul
- David W. Thompson - Jonathan Crane / Scarecrow
- Michael Chiklis - Nathaniel Barnes
- Tonya Pinkins - Ethel Peabody
- Jamie Chung - Valerie Vale
- Paulina Singer - Josie Mac
- Maggie Geha - Ivy Pepper
- Alex Morf - Sykes
- Cameron Monaghan - Jerome Valeska
- Cameron Monaghan - Jeremiah Valeska
- Cameron Monaghan - Joker
- Benedict Samuel - Jervis Tetch / Mad Hatter
- Dan Hedaya - Detective Dix
- Brette Taylor - Martha Wayne
- Anthony Carrigan - Victor Zsasz
- Peyton List - Ivy Pepper / Poison Ivy
- BD Wong - Dr. Hugo Strange
- Grayson McCouch - Thomas Wayne
- Jimmy Palumbo - Detective Boggs
- Andrew Sellon - Mr. Penn / Scarface
- Jerry Walsh - Detective Lewis
- Hunter Jones - Will Thomas
- Seth Clayton - Troublemaker
- Noelle Franco - Nurse
- Mark Aldrich - Cop #1
- Curt Morlaye - Nando
- Will Meyers - Gabriel
- David Kallaway - Tank
- Benjamin Snyder - Boy / Orphan
- Susannah Rogers - Mother
- Curzon Dobell - Doctor
- Tim Simon - Soothsayer
- Johanna Tolentino - Middle-Aged Mother
- Brooke Liddell - Orphan Girl #1
- Kiley Liddell - Orphan Girl #1
- Jamie Chu - Orphan Girl #2
- Deborah Unger - Olga
- J.Stephen Brantley - Street Demonz Leader
- Shane West - Eduardo Durrance / Bane
- John Bedford Lloyd - General Wade
- Jaime Murray - Theresa Walker / Nyssa Al Ghul
- Jaime Murray - Theresa Walker
- Jaime Murray - Theresa Walker (voice)
- Tom Ukah - Lo Boyz Leader
- Mekia Cox - Dr. Thawson
- Mekia Cox - Dr. Leslie Thompkins
- Nicholas Velez - The Undead Leader
- Wyatt Fenner - Shellshocked Refugee
- Victor La Mantia - Refugee #2
- Kevin Herbst - Cop
- Joe Gioco - Elderly Man
- Sean Patrick Doyle - Choir Member
- Joan Porter - Old Lady
- Vick Krishna - Citizen Witness
- Jonathan Holtzman - Grief-Stricken Citizen #1
- Jordan Carey - Grief-Stricken Citizen #2
- Shiva Kalaiselvan - Lelia
- Marceline Hugot - Gretel
- Joseph McKenna - Gerry Grekov
- Renes Rivera - Burly Henchman
- Bill Kux - Plastic Surgeon
- Aaron Dalla Villa - Gretel's Youngest Son
- Geoff Van Wyck - Barker on Megaphone
- Keyanna Murrill - Angry Citizen
- Luke Lesko - Delta #1
- Alex Huynh - Gangster Worker
- Sarah Pidgeon - Jane Cartwright / Jane Doe
- Keil Oakley Zepernick - Burn Man
- Jennifer Honka - Dianne
- Josh Evans - Hank
- Michael Spedden - Dale
- Julian Gamble - Judge
- Sid O'Connell - Mutant Leader
- Eli Bridges - Screaming Junkie
- Eli Bridges - Marv / Screaming Junkie
- Jerry Todisco - Street Demon
- Lili Simmons - Selina Kyle / Catwoman
- Francesca Root-Dodson - Ecco
- Jeté Laurence - Barbara Lee Gordon
- Adam DeCarlo - Reporter
- Dominique DiCaprio - Uni
- Samuel Muriithi - Orderly
- Ann Harada - Mayor Chang
- David Carranza - Angel Vallelunga
- Marlon Perrier - Company Commander
- Tania Asnes - Refugee #1
- David Chen - Nyssa's Guard
- Kawui Joa - Nyssa's Goon
- Nathan Darrow - Victor Fries / Mr. Freeze
- Julia Chan - Karen Jennings
- Peter McRobbie - Mayor Holden Pritchard
- Kyle Massey - Mackey
- Christine Hollingsworth - Zsasz Henchwoman
- Naian González Norvind - Alice Tetch
- David Dastmalchian - Dwight Pollard
- Lynn Marocola - Gothamite Driver (uncredited)
- Lenny Platt - Luke Garrett
- Jonathan Marimow - Pimp
- Warren Katz - Father Callahan
- Gordon Winarick - Tommy Elliot
- Michael Buscemi - Merton
- Jeffrey Combs - Office Manager
- Abbi Snee - Mary Lloyd
- Polly Lee - Alice Pepper
- Robert Jimenez - Raoul
- Ruy Iskandar - Waiter at Fish Mooney's
- Geoffrey Murphy - Big Man in Police Station
- Danny Schoch - Masked Man
- Roberta Colindrez - Female Detective
- Jeremy Sample - Henchman
- Ephraim Birney - Zeb
- Taylor Colwell - Smoke
- David Pendleton - Shad
- Charlie Sausa - Ince
- Jasson Finney - Stevedore
- Odiseas Georgiadis - Street Kid
- Hamilton Clancy - Mechanic
- Garry Pastore - Mobster
- J.W. Cortes - Alvarez
- J.W. Cortes - Detective Alvarez
- Don Hewitt Sr. - Large Thug
- Melody Butiu - Social Worker at Bus
- Andy Striph - Frat Boy
- Michelle Veintimilla - Bridgit Pike / Firefly
- Michelle Veintimilla - Firefly
- Nick Rehberger - Frat Boy
- Laurence Mason - Detective Ben Mueller
- Laurence Mason - Ben Mueller
- Rose Sias - Smiker's Girlfriend
- Pierre Jean Gonzalez - Dishwasher
- John Clarence Stewart - Officer Griffin Katz
- John Clarence Stewart - Griffin Katz
- Ethel Fisher - Grandmother
- Brandon Morris - Thug
- James Georgiades - Manager
- James Georgiades - Restaurant Manager
- Harri Molese - Woman
- Kenneth De Abrew - Man
- Flaco Navaja - Nicky
- Ron Rifkin - Father Creal
- Ron Rifkin - Father Creel
- Danny Doherty - Maroni Thug
- Jamie Choi - Receptionist
- Pearl Sun - Secretary
- Logan Crawford - Reporter
- Mario D'Leon - Mooney Thug
- Mario D'Leon - Underling
- Jake Choi - Gunman
- Carmine Famiglietti - Cashier
- Clyde Baldo - Olaf Nillson
- Philip Hernandez - Medical Examiner
- Andrea Sooch - Mrs. Hastings
- Denia Brache - Anita
- Richard Kind - Mayor Aubrey James
- Richard Kind - Aubrey James
- Mariah Strongin - Shelly Lawson
- Celia Au - Zsasz Henchwoman
- Salvatore Inzerillo - Shotgun
- Alex Corrado - Gabe
- Adrienne Acevedo Lovette - Cocktail Waitress
- Eileen Weisinger - Uniformed Cop
- Bob Roseman - Driver
- Alexis Suarez - Guard
- Robbie Tann - Timothy
- Teodorina Bello - Maggie
- John Quilty - Lawyer
- Danielle Guldin - Receptionist
- Alet Taylor - Rich Woman
- Bryce Biederman - Coleman Lawson
- Brian Morvant - Adams
- Jay Hieron - Patient
- Gabriel Rush - Roy
- Melvin Abston - Senior Corrections Officer
- Andrew Ayala - Munitions Security Officer
- Guyviaud Joseph - Munitions Security Officer
- John Finnerty Jr. - Gardener
- Declan Mulvey - Assassin
- Allyce Beasley - Nurse Dorothy Duncan
- Kevin McCormick - Aaron Danzig
- Anthony Grasso - Ganza
- Isiah Whitlock Jr. - Gerry Lang
- Steve Axelrod - Fisherman
- Adrian Martinez - Irwin
- Richard Poe - Mr. Kean
- Giovanni Roselli - Mobster
- Filipe Valle Costa - Cop
- Michael Eklund - Bob
- Willie C. Carpenter - Leon Winkler
- Berto Colon - Narco Cop
- Lorrie Odom - Olga
- Fernando Mateo Jr. - Marco
- Larry Nuñez - Anatoly
- Krista Braun - TV Reporter
- Krista Braun - Jennifer Luree
- Krista Braun - Field Reporter
- Krista Braun - News Reporter
- Krista Braun - TV News Reporter
- Krista Braun - Reporter on TV
- Krista Braun - Journalist
- Krista Braun - Studio Reporter
- Izzy Ruiz - Detective
- Maria Christina Thayer - Scottie Mullens
- Brian Keane - Boat Captain
- Lillias White - Choir Member
- Roberto Lopez - Henchman
- Roberto Lopez - Bodyguard
- Robert G. McKay - Sargeant Joe
- Tuffy Questell - Duffy
- Aaron Marcus - Tightly Wound Man
- Jim Ford - Adam Jodowsky
- Dashiell Eaves - Kelly
- Babs Olusanmokun - Mace
- Eisa Davis - Judith Barthel
- Peter Jay Fernandez - Doctor Anderson
- Calvin Ahn - Delta #2
- Calvin Ahn - Prison Guard
- Dorothea Harahan - Karen Crane
- James Rutledge - Gennaro Marx
- Munro M. Bonnell - Judge Turnball
- Niahlah Hope - Lone Woman
- Jeremy Bobb - Owen Lloyd
- Slate Holmgren - Alphonse Grayson
- James Monroe Iglehart - Ringmaster
- Elliot Villar - Thomas Schmidt
- Marcin Paluch - Foolhardy Drunk
- Simon Feil - Board Member
- Vanessa Kai - Board Member
- Jonny Coyne - Destro
- Jenna Gavigan - Bank Manager's Secretary
- Lee Wong - Chiang
- Peter Brensinger - Trope
- Kevin T. Collins - Regan
- Peter Albrink - Haskins
- Michael Goldsmith - Floyd
- Nat DeWolf - Bank Manager
- Sean Crespo - Comedian
- Marc Basil - Policeman
- Michael Rosete - Workman
- Becky Ann Baker - Marge
- Dan Ziskie - Jude
- Nicholle Tom - Miriam Loeb
- Zachary Spicer - Tom Dougherty
- Michael J. Burg - Charley Griggs
- Colm Feore - Dr. Francis Dulmacher
- Rob DeRosa - Scarred Man
- Brendan Griffin - Len Moore
- Barbara Rosenblat - Lidia Bicchieri
- Brendan Burke - Bugsy
- Sean Ringgold - Clint
- Alaska L. McFadden - Bartender
- Dan Domenech - Guitar Player
- Joe Lanza - Officer Zeke
- Joe Lanza - Detective Zeke
- Daniel Davis - Jacob Skolimski
- Michael McCormick - Dr. Darren Cushman
- Clark Carmichael - Connor
- Anthony Hoang - Delivery Man
- Isaiah Mueller - Tough
- James Andrew O'Connor - Tommy Bones
- Tonya Glanz - Sally
- April Yvette Thompson - Lucy
- Paul Bomba - Cheech
- Z Infante - Jake
- Erica Camarano - P.R. Woman
- Brian Distance - Security Guard
- David Fierro - Zaardon
- Otto Sanchez - Odgen Barker
- Michael Barra - Officer Franks
- Philip Goodwin - Compere
- Brian McManamon - Basil / Clayface
- Neil Hellegers - Doctor #1
- Vanessa Morales - Doctor #2
- Natasha Diamond Walker - Reporter #2
- Shadner Ifrene - Fish Mooney's Guard
- Ian Lyons - Guard
- Stefanie Bloom - Dancer
- Frank Modica - GCPD CORE Detective
- Thom Sesma - Barthel
- Gregory Konow - Detective
- Fidel Vicioso - Sergeant
- Eric Elizaga - Reporter
- Charmaine Reedy - Venue Official
- Michael Mulheren - Randall Hobbs
- Ian Quinlan - Carl Pinkney
- Danny Garcia - Detective Perez
- Jay Aubrey Jones - City Official
- Luciana Faulhaber - Journalist
- Astrea Campbell-Cobb - Punk Girl
- Young-H. Lee - Gang Leader
- Tiffany Villarin - Volunteer
- Mary Joy - Edwige
- Brian S. Carpenter - Jonathan Wayne
- Sean Patrick Folster - Stretch
- Fenton Lawless - Clerk
- Gregory Chater - Nervous Man
- Marckenson Charles - Orderly
- Kent R. Williams - Falcone Hitman (uncredited)
- Alberto Bonilla - TV Pundit
- Brian Donahue - Hunter
- Jon Sklaroff - Billy Boy
- Ashlei Sharpe Chestnut - Officer Parks
- Kelly Miller - Leonard
- Joel Haberli - Doctor
- Branden Wellington - Young Guard
- Edward Gabree - Uniformed Cop
- Tommy Flanagan - Tom the Knife
- Ellen Harvey - Judge
- Guy Lemonnier - Galavan's Lawyer
- Ambre Anderson - EMT
- Adrian Matilla - Monk
- Kit Flanagan - White Haired Woman
- Kit Flanagan - The White Haired Woman
- Nnamdi Nwosa - Monk
- Tony Rossi - Business Man
- Kristen Hager - Nora Fries
- John Pirkis - Nigel
- Shamika Cotton - Officer Holt
- Danny Hoch - Pharmacist
- Yinka Adeboyeku - Uniformed Officer
- Rob Byrnes - Loonie
- Chris Northrop - Loonie
- Patrick Vincent Curran - Loonie
- Jason Martin - Thief
- Mick O'Rourke - Ace Chemicals Janitor
- Lori Petty - Jeri
- Michael Bowen - Matches Malone
- Jamar Greene - Cupcake
- Melinda Clarke - Grace Van Dahl
- Kaley Ronayne - Sasha Van Dahl
- Justin Mark - Charles Van Dahl
- Donna Del Bueno - Nurse
- Marcel Simoneau - Gilzean's Henchman
- Ned Bellamy - Warden Carlson Grey
- Peter Mark Kendall - Puck Davies
- Marc Damon Johnson - Wilson Bishop
- Moisés Acevedo - Young Inmate
- Trevor E. Dickerson - Bullish Guard
- Robert Emmet Lunney - Doctor
- James Dinonno - Huge Bald Inmate
- James P. Rees - Dancing Prisoner
- Warren Bub - Officer Barkley
- Michael McFadden - Gangster
- Hannah Scott - White Gloves
- Jacqueline O. Rene - Bert
- Edvin Ortega - GCPD Cop
- Norm Golden - Security Guard
- Guy Lockard - Thug
- Christopher Place - Hitman
- Neimah Djourabchi - Hitman
- Brett Azar - Hitman
- Tommy Buck - Rudy
- Molly Camp - Sharon
- Gabrielle Reid - Paramedic
- Radu Spinghel - Scale Skin Man
- Larry Petersen - Priest
- Devale Ellis - Orderly
- Austin Michael Young - Cop
- Tama Filianga - Guard
- Gerard Cordero - Strike Force Lieutenant
- James Carpinello - Mario Falcone
- Victor Pagan - Marv
- Nikolai Tsankov - Boris
- Brian Cade - Board Member
- Bianca Rutigliano - Nancy
- Kevin Michael Murphy - Plant Worker
- Kenny Wong - Pharmacist
- Bobby Beckles - Security Guard
- Michael Montgomery - Ridgeback Monster
- Michael Lorz - Sid
- Charlie Huston
- Alex R. Wagner
Hakeem Kae-Kazim interpreta a Richard Gladwell en la serie.
Lili Taylor hace el papel de Patti.
John Doman hace el papel de Carmine Falcone.
Alexander Siddig hace el papel de Ra's al Ghul.
Mark Margolis interpreta a Paul Cicero en la serie.
Tommy Flanagan interpreta a Tom the Knife en la serie.
David O'Hara interpreta a Reggie Payne en la serie.
Wayne Duvall hace el papel de Morry Quillan.
Ben McKenzie interpreta a Jim Gordon en la serie.
Donal Logue interpreta a Harvey Bullock en la serie.
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