- Tessie Santiago - Lucia Rojas-Klein
- Suzanne Pleshette - Claire Arnold
- Brooke Dillman - Sister Brenda Trogman
- Andrea Savage - Cindy
- Tiffani Thiessen - Victoria Hill
- Amy Farrington - Erika
- Jolie Jenkins - Cheryl
- Stephon Fuller - Robby
- Amy Rider - Self
- Viola Kates Stimpson - Old Woman
- Walter Addison - Dr. Seltzer
- Jordan Feldman - Guy
- Butch Klein - Dale the Delivery Guy
- John Balma - Maitre d'
- Karen Bankhead - Nurse Becker
- Kenneth Mars - Marty
- Bess Armstrong - Louise Messinger
- Lydia Blanco Garza - Nurse Debbie
- Christopher Gehrman - Water Guy
- Loren Lester - Group Leader
- Madison Mason - Soldier
- Tom Poston - Lenny
- Lori Alan - Loretta
- Doug Ballard - Walter
- Rafer Weigel - Adam
- Fran Drescher - Roberta Diaz
- Nick Offerman - Officer
- Dat Phan - Co-worker
- Joe Rogan - Self
- Katherine Disque - Group Member
- J. Michael Flynn - Paolo
- Sierra Abel - Jamie
- Jackie Geary - Angela
- Bob Morrisey - Bert
- Anne Meara - Claire's Friend
- Carrie Preston - Kiera
- Michael Alaimo - Violinist
- Jillian Warry Barberie - Joni
- Tina D'Marco - Conchita-the parrot
- Jeremy Forte - Howard
- Ted Allen - Self
- Brian Howe - Steve
- Carson Kressley - Self
- Jai Rodriguez - Self
- T.J. Thyne - Trevor
- Bob Clendenin - Carl
- Jeff D'Agostino - Ty
- Niyi Oni - Jay
- Mary Lynn Rajskub - Hollis
- Tony Ervolina - Man
- Wallace Langham - Ken
- Myrna Niles - Woman
- Burgess Jenkins - Jimmy
- Brian Palermo - Trip
- Sarah Rafferty - Lila
- Matthew Glave - Phil
- Tracy Vilar - Stacey
- John Aylward - Mr. Fowler
- Carrie Fisher - Judy Silver
- Hal Holbrook - Jim Templeton
- Steve Paymer - Lloyd
- Terry Rhoads - Howie
- Dina Sherman - Sandra
- Billy West - Billy
- Chad Gabriel - Store Employee
- Deborah Levin - Frances
- Michael Medico - Bartender
- Suzy Nakamura - Carol
- Todd Stashwick - Nick
- Edward James Gage - Tiny
- Sam Pancake - Jordy
- Curtis Armstrong - Jeweler
- Paul Tigue - Father Bowman
- Kevin Brief - Troy
- Valerie Mahaffey - Sara
- Paul Anthony Reynolds - Mike
- Will Collyer - Steve
- Joey Hardy Gray - Brian
- Shira Scott Astrof - Sara
- Joanna Cassidy - Catherine
- Joanna Cassidy - Gavin's Mother
- Kristina Lear - Seba
- Shashawnee Hall - Reverend Earl
- George Wyner - Larry
Capítulo disponible en las siguientes plataformas:
